Preparation method of physalis alkekengi extract and application of physalis alkekengi extract as bulk drug

A technology of brocade lanterns, extracts, applied in the field of medicine

Inactive Publication Date: 2021-05-11
广东安道医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the medical use of the extract of brocade lanterns, especially the detailed research on the treatment of skin allergies and acne

Method used

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  • Preparation method of physalis alkekengi extract and application of physalis alkekengi extract as bulk drug
  • Preparation method of physalis alkekengi extract and application of physalis alkekengi extract as bulk drug
  • Preparation method of physalis alkekengi extract and application of physalis alkekengi extract as bulk drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step Ⅰ: take 50g brocade lantern medicinal material and cut into pieces, put it into a flask;

[0031] Step Ⅱ: Take 1.5L of 70% ethanol prepared with 95% ethanol and add it to the flask, and carry out the first reflux extraction operation on the shredded brocade lantern medicinal material in the flask, and the 70% ethanol in the flask starts to boil to keep the The 70% ethanol in the flask is boiling state 2h, then extract the first filtrate in the first part of reflux liquid with suction filtration, keep the filter residue in the first part of reflux liquid;

[0032] Step III: Add the filter residue into the flask, and use the 70% ethanol remaining in the flask after the first reflux extraction operation to perform a second reflux extraction on the filter residue in the flask after adding the filter residue Operation, the remaining 70% ethanol in the flask starts to boil and keep the remaining 70% ethanol in the flask in a boiling state for 2h, then extract the second ...

Embodiment 2

[0035] Step Ⅰ: take 45g brocade lantern medicinal material and cut into pieces, put it into a flask;

[0036] Step Ⅱ: Take 1.5L of 70% ethanol prepared by recovering ethanol and add it to the flask, and carry out the first reflux extraction operation on the shredded brocade lantern medicinal material in the flask, and the 70% ethanol in the flask starts to boil to keep the The 70% ethanol in the flask is in boiling state for 2h, then extract the first filtrate in the first part of reflux liquid by suction filtration, and keep the filter residue in the first part of reflux liquid;

[0037] Step III: Add the filter residue into the flask, and use the 70% ethanol remaining in the flask after the first reflux extraction operation to perform a second reflux extraction on the filter residue in the flask after adding the filter residue Operation, the remaining 70% ethanol in the flask starts to boil and keep the remaining 70% ethanol in the flask in a boiling state for 2h, then extra...

Embodiment 3

[0040] The application of brocade lantern extract as a raw material drug as a test substance for inhibiting the release of hyaluronidase

[0041] (1) prepare the acetic acid buffer solution of pH=5 with glacial acetic acid dilution solution and sodium acetate crystallization aqueous solution, stand-by; Prepare respectively the hyaluronidase solution and the concentration that are 0.5g with the prepared acetic acid buffer solution that concentration is 1250U / mL / L sodium hyaluronate solution;

[0042] (2) Prepare brocade lantern extract according to the method of embodiment 1 or embodiment 2, and the prepared brocade lantern extract is formulated into mass concentration respectively 0.10g / L, 0.25g / L, 0.50g / L, 1.00 g / L, 1.50g / L, 2.00g / L, 2.50g / L brocade lantern extract, as the experimental group; the preparation mass concentration is respectively 0.10g / L, 0.25g / L, 0.50g / L, 1.00g / L, 1.50g / L, 2.00g / L, the dipotassium glycyrrhizinate solution of 2.50g / L as positive control group;...

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Abstract

The invention discloses a preparation method of a physalis alkekengi extract and application of the physalis alkekengi extract as a bulk drug. The physalis alkekengi extract is prepared from a physalis alkekengi medicinal material as a raw material; a method for preparing the physalis alkekengi extract is simple; the raw material is easy to obtain; in research on application of the physalis alkekengi extract as the bulk drug, the prepared physalis alkekengi extract is used for preparing a solution, namely a physalis alkekengi extracting solution, according to the required mass concentration; the physalis alkekengi extract serves as the bulk drug to be applied to inhibition of hyaluronidase, inhibition of release of histamine in RBL-2H3 cells and inhibition of growth of propionibacterium acnes and staphylococcus epidermidis; and by the application, it is found that the calyx physalis alkekengi extract serving as the bulk drug has the functions of resisting allergy and treating allergic reaction, and meanwhile, the physalis alkekengi extract serving as the bulk drug can also treat acne.

Description

technical field [0001] The invention discloses a preparation method of a brocade lantern extract and its application as a raw material drug, belonging to the technical field of medicine. Background technique [0002] Brocade lantern (Physalis alkekengi L var.franchetii (Mast.) Makino) is the dry persistent calyx or persistent calyx with fruit of Solanaceae (Solanaceae) Physalis genus (Physalis), also known as red girl, Physalis, hanging golden lamp, etc. . It is cold in nature, bitter in taste, and returns to the lung meridian. Originated in China, it is mainly distributed in Northeast, Northwest, Inner Mongolia and other places. First recorded in "Shen Nong's Materia Medica", it is named sour sauce and is listed as a middle-grade product. It has the effects of clearing away heat and detoxification, dispersing fire and reducing swelling. Afterwards, there were many books on herbal medicines in successive dynasties. In Ming Dynasty Li Shizhen's "Compendium of Materia Medic...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P17/10A61P17/00A61P31/04A61P37/08
CPCA61K36/81A61P17/10A61P17/00A61P31/04A61P37/08A61K2236/333A61K2236/39A61K2236/51
Inventor 舒尊鹏
Owner 广东安道医疗器械有限公司
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