Supercharge Your Innovation With Domain-Expert AI Agents!

Combination including isoglycyrrhizinate and oxymatrine and the purpose thereof

A technology of isoglycyrrhizinic acid and its composition, applied in the field of medicine, can solve the problems of malabsorption, low bioavailability, inconvenient taking by patients, good quality, etc.

Active Publication Date: 2010-06-09
CHIA TAI TIANQING PHARMA GRP CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the steroid-like effect of glycyrrhizic acid, there are serious adverse reactions such as water and sodium retention, high blood pressure and hypokalemia after long-term administration, and oral administration is easy to form micelles in the intestinal tract, resulting in malabsorption and low bioavailability
The clinical efficacy of matrine drugs is not good, and they have been used for the treatment of hepatitis B for a long time, and have gastrointestinal irritation
There are clinical reports that the combined application of diammonium glycyrrhizinate capsules and matrine injection has achieved good curative effect in the treatment of chronic hepatitis B, but this method has not completely solved the problem of poor absorption of oral preparations of glycyrrhizinate, excessive side effects, and excessive dosage of combined drugs. The problem of inconvenient use for large patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Magnesium isoglycyrrhizinate and matrine in different proportions on CCL 4 Protective effect of induced liver injury in mice

[0021] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002

[0022] Experimental drugs: matrine, magnesium isoglycyrrhizinate. Provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002. According to the requirements of the experiment, the solutions with different proportions of concentration were prepared with physiological saline.

[0023] 70 Kunming mice of 18-20g, male, were randomly divided into 7 groups according to body weight: normal control group, model control group, 3 groups of matrine and magnesium isoglycyrrhizinate composition group with different ratios, matrine group, magnesium isoglycyrrhizinate group. According to d...

Embodiment 2

[0027] Example 2 The protective effect of the composition of magnesium isoglycyrrhizinate and matrine in different ratios on immune liver injury in mice induced by BCG+LPS.

[0028] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002

[0029] Experimental drugs: magnesium isoglycyrrhizinate and matrine were provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002. According to the requirements of the experiment, physiological saline was used to make solutions with different proportion concentrations for injection administration. Bacillus Calmette-Guerin (BCG): Shanghai Institute of Biological Products, batch number: 200504001. Lipopolysaccharide (LPS): product of Sigma, USA. AST and ALT kits: Nanjing Jiancheng Institute of Bioengineering, batch number: 20050905, 20050828. ...

Embodiment 3

[0035] Embodiment 3 acute toxicity test

[0036] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002.

[0037] Experimental drugs: magnesium isoglycyrrhizinate, matrine. Provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002.

[0038] Test according to the requirements of acute toxicity test. The LD of the following groups of experimental drugs were obtained respectively 50 value,

[0039] Table 3. Mice acute toxicity test LD of different ratios of magnesium isoglycyrrhizinate and matrine 50

[0040] Note: "Bitter" means matrine; "Isokan" means magnesium isoglycyrrhizinate. The mass ratio between matrine and magnesium isoglycyrrhizinate.

[0041] From the results of the acute toxicity test, it can be known that the combination of matrine and magnesium isoglycyrrhiz...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a medicinal composition which comprises kurarinone or its derivatives and isoglycyrrhizinic acid or its derivatives. The invention also provides the use of the pharmaceutical composition in treating acute and chronic hepatitis and related diseases. the invention also provides various dosage forms of the pharmaceutical composition.

Description

technical field [0001] The invention belongs to the field of medicine. It relates to a pharmaceutical composition and its application. The pharmaceutical composition contains isoglycyrrhizic acid and matrine or their derivatives. And the application of the pharmaceutical composition in preventing and treating human hepatitis or hepatitis-related diseases or tumors. Background technique [0002] Liver disease, especially viral hepatitis, is a common and frequently-occurring disease in my country. At present, there is no drug with ideal therapeutic effect on it. Clinically, antiviral drugs are often used for treatment, and liver-protecting drugs are added to improve the curative effect. However, due to the inaccurate therapeutic effect and strong clinical side effects of such drugs, the prognosis is often unsatisfactory. [0003] Both glycyrrhizic acid and matrine have certain anti-hepatitis virus and liver protection effects, and similar products of the two have been use...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P1/16A61P31/20A61P31/14A61K31/4375
Inventor 沈军耿文军于飞
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com