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Vesicle guiding immunocyte and application of the same in preparing antineoplastic medicine

A technology of immune cells and vesicles, applied in the field of biomedicine, can solve the problems of high and low efficiency of dendritic cells, low efficiency of dendritic cells, etc.

Active Publication Date: 2007-12-12
项雯华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

We previously found that the efficiency of dendritic cell vaccine anti-tumor immunity depends on the degree of maturity of dendritic cells, with high efficiency in mature dendritic cells and low efficiency in semi-mature dendritic cells (21)
Moreover, the low efficiency of vesicle vaccines may be related to the uptake of vesicles by immature dendritic cells in vivo

Method used

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  • Vesicle guiding immunocyte and application of the same in preparing antineoplastic medicine
  • Vesicle guiding immunocyte and application of the same in preparing antineoplastic medicine
  • Vesicle guiding immunocyte and application of the same in preparing antineoplastic medicine

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Embodiment Construction

[0032]The present invention shows that dendritic cells and T cells can acquire vesicles derived from dendritic cells and tumor cells. In particular, these cells are able to acquire histocompatibility complexes and co-stimulatory molecules from the vesicles. The present invention shows that these vesicle-derived molecules are functional. In this way, vesicle-directed dendritic cells and T cells can directly stimulate the immune response.

[0033] The present invention accordingly provides a method for preparing vesicle-directed dendritic cells. These include contacting vesicles derived from antigen-loaded dendritic cells or engineered tumor cells with other dendritic cells under certain conditions to facilitate the acquisition of the vesicles by dendritic cells.

[0034] The present invention also correspondingly provides a method for preparing vesicle-directed CD4 + T cell approach. These include vesicles derived from antibody-loaded dendritic cells or engineered tumor cel...

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Abstract

The invention provides an immunological active Chinese medicinal composition which comprises effective dose of vesicle oriented immunological cell and medicinal carrier material. The invention also provides a method for preparing the immunological active Chinese medicinal composition, and provides preparation method of vesicle oriented immunological cell. The invention also provides an application of the immunological active Chinese medicinal composition in preparing medicament for resisting tumor, and inhibiting autoimmune disease and / or inhibiting rejection reaction.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to immune regulation and disease prevention, and more specifically to providing an immunoactive pharmaceutical composition, which contains an effective amount of vesicle-directed immune cells, and is used in the preparation of anti-tumor, inhibition of autoimmune diseases and / or the application of drugs to inhibit rejection. Background technique [0002] Dendritic cells (DC) process foreign antigens in the vesicle compartment, such as multivesicular vesicles (1) that can fuse with the cell membrane, and then release antigen-presenting vesicles called exosomes (EXO) (2 -4). Vesicles are 50-90nm in diameter containing antigen-presenting molecules (MHCI, MHCII, CD1, hsp70-90); tetrameric molecules (CD9, CD63, CD81); adhesion molecules (CD11b, CD54) and co-stimulatory molecules CD86, etc. Elements necessary for the initiation of a potential immune response (5-7). Zitvogel et al. ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K39/39A61P35/00A61P37/06A61P37/02
Inventor 项建华
Owner 项雯华
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