Method and kit for detecting a risk of essential arterial hypertension

A technology of risk and susceptibility, applied in the diagnosis or detection of HT tendency or susceptibility or susceptibility, the field of the kit for implementing the method can solve problems such as failure, and achieve the effect of reducing the debilitating effect

Inactive Publication Date: 2008-01-09
JURILAB
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0038] Traditional GWS and linkage analysis using microsatellite markers are unsuccessful in the discovery of genes responsible for common diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0165] HT patients and phenotypic characteristics in Eastern Finland

[0166] Subjects were participants in the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), an ongoing promising population-based study designed to study risk factors for chronic diseases including HT and CVD in middle-aged adults (Salonen JT 1988, Salonen JT et al 1998, 1999, Tuomainen T-P et al 1999). The study population was a random age-grouped sample of men living in Eastern Finland who were 42, 48, 54 or 60 years old at baseline in 1984-1989. A total of 2682 men were studied during 1984-89. During the 11th year of follow-up of the male cohort, the male cohort was supplemented by a random population sample of 920 women first examined in 1998-2001. Recruitment and testing of subjects was previously described in detail (Salonen JT, 1988). The Kuopio University Research Ethics Committee approved the study. All participants provided written consent.

[0167] The analysis was based on the followin...

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PUM

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Abstract

Genes, SNP markers and haplotypes of susceptibility or predisposition to hypertension (HT) are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for HT using polymorphisms in the HT risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of HT. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of HT.

Description

field of invention [0001] The present invention relates generally to the field of diagnosis of cardiovascular diseases (CVD), such as arterial hypertension (HT). More specifically, methods of diagnosing or detecting HT predisposition or predisposition or susceptibility are provided. In particular, the present invention focuses on a method comprising the steps of providing a test biological sample from a subject and detecting the presence or missing. In addition, the present invention utilizes genetic and phenotypic information as well as information obtained through questionnaires to construct a score that provides the likelihood of suffering from HT. Furthermore, the invention provides kits for carrying out the methods. The kit can be used to establish an etiology-based diagnosis of HT, to target therapeutic approaches and preventive interventions such as dietary advice, and to stratify subjects in clinical trials testing drugs and other interventions . Background techn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12QG16H10/40G16H10/60G16H50/30
CPCC12Q2600/112C12Q2600/156C12Q2600/172G06Q50/24C12Q2600/158C12Q2600/106C12Q1/6883C12Q2600/136A61P9/12G16H10/60G16H50/30G16H10/40Y02A90/10
Inventor 朱卡·T·萨洛嫩朱哈-马蒂·阿尔托里卡多·富恩特斯奥蒂·康特卡嫩米娅·皮尔斯卡嫩佩卡·尤马里
Owner JURILAB
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