Isothiuronium salt and method of manufacturing the same and method for manufacturing substituted benzene ethyl mercaptan compounds

Abstract

The invention belongs to the organic synthesis field, in particular to the isothiourca salt and the preparation method and the method using the isothiourca salt to prepare and replace the 2-phenylethylmercaptan component. The structural formula of the isothiourca salt (IV) refers to the drawing, wherein, R is the alkyl of the hydrogen, halogen atom or C1-C4 and X is the anionic group which can acidify. The invention also discloses the preparation method of the isothiourca salt and the method using the isothiourca to prepare and replace the 2-phenylethylmercaptan component. Because of adoptingthe above technical proposal, the invention provides the isothiourca salt to replace the 2-phenylethylmercaptan component. Using the method to prepare and replace the 2-phenylethylmercaptan componentis characterized by simple operation, low cost, high yield and easy industrialization.

Description

technical field The invention belongs to the field of organic synthesis, and in particular relates to isothiouronium salts, a preparation method thereof and a method for preparing substituted phenethanethiol compounds with it. Background technique Substituted phenylethanethiol compounds are important intermediates in organic synthesis, and are also raw materials for the preparation of phenylethanesulfonic acid, a good resolution agent for amino acids such as leucine. Patent US2402613 discloses a method for preparing mercaptans by catalytic hydrogenation and hydrolysis of thiocarbonyl groups. This method has high cost, low yield, cumbersome operation, and cannot realize industrial production. Patent US4161493 reports the exchange reaction of thioaldehyde or thioketone and thiol to obtain corresponding products. Although this method has the characteristics of high selectivity and conversion rate, it is difficult to separate the main product and by-product, thus hindering the i...

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Problems solved by technology

Patent US2402613 discloses a method for preparing mercaptans by catalytic hydrogenation and hydrolysis of thiocarbonyl groups. This method has high cost, low yield, cumbersome operation, and cannot realize industrial production

Patent US4161493 reports the exchange reaction of thioaldehyde or thioketone and thiol to obtain corresponding products. Although this method has the characteristics of high selectivity and conversion rate, it is difficult to separate the main product and by-product, thus hindering the industrial application of this method.

The article ("Journal of Chemical Society of Japan", 1987, (7), P.1502-1504) published by Murai Shinji etc. adopts the method that sulfur, carbon monoxide and water react with aromatic hydrocarbon ketone and aldehyde to prepare mercaptan, although the method has higher yield High, but the carbon monoxide discharged after the reaction has a great pressure on environmental protection, which limits the commercial production of this method

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