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Malaria-resisting arteannuin naphthoquine compound composition

A composition and technology of artemisinin, applied in the direction of drug combination, active ingredients of heterocyclic compounds, and resistance to vector-borne diseases, etc., can solve the problems of raw material cost and less toxic and side effects, and achieve the effect of easy acceptance and promotion, and guaranteed effect

Active Publication Date: 2010-09-29
李国桥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above-mentioned products can meet the general purpose of treating malaria, there is still a need for better raw materials, simpler processes, lower cost of raw materials, better stability, less toxic and side effects, the same high-efficiency and quick-acting effects, and more rapid blockade Antimalarial drugs for malaria transmission

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Accurately weigh 160 g of artemisinin, 400 g of naphthoquine, and 4 g of primaquine, and mix them, then add 28 g of hydroxypropyl cellulose and 34 g of compressible starch, and mix well. Mix the above raw and auxiliary materials evenly, add 3% hydroxypropyl methylcellulose pulp to make a soft material, granulate through a 12-mesh sieve, and dry at 60°C±2°C to control the water content of the granules to 2.5%-3.5% . Sieve the dry granules with a 16-mesh sieve, then add 5% sodium carboxymethyl starch and 1.0% magnesium stearate by weight of the dry granules, mix well, accurately weigh an appropriate amount, measure the drug content, and calculate the set tablet weight , Use special-shaped punching dies to make 1000 pieces. Add the Opadry film coating material into 80% ethanol, stir and disperse evenly, pass through a 100-mesh sieve for later use. Put the tablets into the coating pan, preheat to 40-50°C, adjust the air pressure of the spray gun and the flow rate of the c...

experiment example

[0026] The present inventor uses the composition of the present invention to compare with the medicine of the control group to carry out clinical research.

[0027] A total of 315 cases of uncomplicated falciparum malaria were treated in the highly endemic area of ​​multidrug-resistant falciparum malaria on the Cambodian-Thailand border in western Cambodia, including 103 cases of artemisinin naphthoquine tablets (artemisinin 160mg + naphthoquine 400mg + primaquine 4mg) group , orally give the patient 2 tablets at a time. In the control group, 212 cases of compound naphthoquine phosphate tablets (dihydroartemisinin 100 mg + naphthoquine phosphate 600 mg + trimethoprim 200 mg) were administered orally for two days, one tablet per day. Follow up and review the resurgence of protozoa once a week. The main curative effect judging indicators include cure rate, protozoa resurgence rate, average protozoa negative time, and average fever-reducing time. The results showed that the ave...

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PUM

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Abstract

The invention discloses a medicine combination used to cure or prevent malaria, which basically consists of arteannuin or derivatives thereof, naphthoquine and primaquine. The invention can be used in curing malignant malaria, quartan malaria and tertian malaria and is particularly suitable to cure malignant malaria with multi-drug resistance through adopting one dose therapeutics. The invention has good curative effect, less toxic and side effect and low cost, thereby being particularly suitable for fast control and elimination of malaria in various regions.

Description

technical field [0001] The present invention relates to a compound antimalarial pharmaceutical composition, more specifically to an artemisinin-naphthoquine compound antimalarial pharmaceutical composition, a preparation method thereof and an application for preparing a medicine for preventing, treating and controlling malaria. Background technique [0002] Malaria has always been a serious infectious disease that endangers human life and health. Malaria is prevalent in many countries and regions including Africa, Southeast Asia and China. Some unilateral antimalarial drugs are known in the prior art, but none of them can achieve a sustained high cure rate and prevent drug resistance, nor can they rapidly block transmission and control the prevalence of malaria. [0003] Chinese patent application 97111840.X discloses a method for preparing antimalarial compound naphthoquine phosphate, which comprises mixing naphthoquine phosphate and artemisinin antimalarial compounds in a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K31/675A61K47/34A61K9/20A61K9/48A61K9/08A61K9/02A61K9/10A61P33/06A61K47/38
CPCY02A50/30
Inventor 李国桥宋健平
Owner 李国桥
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