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FK506 topical application sustained release film patch of immunosuppressive agent for accelerating regeneration of nerve, method of producing the same and use of the same

An immunosuppressant, slow-release film technology, applied in the field of immunosuppressants to promote nerve regeneration, to achieve the effects of protecting neurons, small fluctuations in drug concentration, and short use time

Inactive Publication Date: 2008-02-27
深圳市宝安区沙井人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of immunosuppressant FK506 to inhibit the immune rejection of allogeneic nerve transplantation has been studied for several years, but there is no relevant report at home and abroad on the application of FK506 to promote the regeneration of directly anastomotic nerves

Method used

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  • FK506 topical application sustained release film patch of immunosuppressive agent for accelerating regeneration of nerve, method of producing the same and use of the same

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Effect test

Embodiment Construction

[0019] The local application of the immunosuppressant FK506 for promoting nerve regeneration of the present invention is a flexible drug film formed by implanting the immunosuppressant FK506 into a slow-release carrier, which is used for local use on specific parts of the body during transplant surgery , so that peripheral nerve damage can be repaired and regenerated. Among them, FK506 is a well-known immunosuppressant, usually used for oral or injection. Described sustained-release carrier adopts biodegradable biopolymer material, preferred polylactic acid (PLA) in this example [2] And the copolymer (PLGA) of polyglycolic acid (PGA), this copolymer is methoxy polyethylene glycol-polylactic acid diblock copolymer, and its molecular weight is 25000.

[0020] The sustained-release film is a composition of nano-scale microspheres, which is formed by mixing the immunosuppressant FK506 and the above-mentioned slow-release carrier at a ratio of 1:4 (weight percentage), and the part...

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Abstract

The invention discloses a slow release diaphragm and making method and application to do local usage of immune inhibitor FK506 to accelerate the regeneration of nerve, which is characterized by the following: the slow release diaphragm can be copolymer (PLGA) of decomposably biological macromolecular material-polylactic acid (PLA) [2] and polyglycolic acid (PGA), which is composed of immune inhibitor FK506 and slow release carrier. The making method of the slow release diaphragm comprises the following steps: a. reacting polylactic acid (PLA) [2] and polyglycolic acid (PGA) to produce the copolymer PLGA; b. blending the copolymer PLGA and FK506; adding the mixture into deionized water to dilute; removing organic solvent; stirring under indoor temperature to evaporate the solvent; freezing; drying; obtaining nanometer microball; c. using the nanometer microball into drug diaphragm to make local exterior drug to restore the peripheral nerve damage.

Description

【Technical field】 [0001] The present invention relates to drug sustained-release agent, in particular to an immunosuppressant FK506 local application sustained-release film for promoting nerve regeneration and its preparation method and application. 【Background technique】 [0002] The repair of peripheral nerve injury is a worldwide problem, and peripheral nerve injury is a high incidence in my country, especially hand surgery often involves peripheral nerve injury. Due to the slow rate of nerve regeneration after peripheral nerve injury, the long-term denervated target organs have dysfunction, causing mental and physical pain for such patients, and bringing serious sequelae to patients. Society has brought a series of adverse effects, increasing the social burden. [0003] In the clinical work of peripheral nerve injury repair, the incidence of simple nerve injury accounts for more than 90%, and most of them require direct anastomosis repair. At present, the research and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/436A61K9/70A61K47/34A61P37/06A61P25/02
Inventor 张振伟
Owner 深圳市宝安区沙井人民医院
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