Method for preparing active parts in scutellaria decoction for treating ulcer colonitis and uses

A technology for ulcerative colitis and active parts, which is applied in the field of extraction of active parts of traditional Chinese medicine compound, can solve the problems of the preparation method of active parts of Huangqin Decoction and its application research reports, and achieve remarkable results

Inactive Publication Date: 2011-01-12
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Chinese Journal of Traditional Chinese Medicine, 1990, Vol. 15, No. 2), but there is no research report on the preparation method and application of the active part of Huangqin Decoction

Method used

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  • Method for preparing active parts in scutellaria decoction for treating ulcer colonitis and uses
  • Method for preparing active parts in scutellaria decoction for treating ulcer colonitis and uses
  • Method for preparing active parts in scutellaria decoction for treating ulcer colonitis and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Take 3.0 kg of Huangqin Decoction medicinal materials according to the prescription, add 2 times (V / W) crude drug amount of 70% ethanol solution, stir evenly, and place for 8 hours. Then add 5 times of 70% ethanol solution and heat to reflux for 1.5 hours, filter and repeat twice, and combine the extracts.

[0028] 2. The above extract was concentrated under reduced pressure at 50-75°C under the condition of 0.05MP to obtain an extract with a specific gravity of 1.10 (60°C).

[0029] 3. Add the extracted extract obtained above to a chromatographic column equipped with 3.0kg D-101 macroporous adsorption resin, and elute with 7 times column volume of water, followed by elution with 6 times column volume of 80% ethanol solution . Collect the 80% ethanol eluate.

[0030] 4. Concentrate the 80% ethanol eluate above at 0.05MP under reduced pressure at 70° C. to an extract with a relative density of 1.20 (60° C.), and dry it at 75° C. under reduced pressure to obtain 323 ...

Embodiment 2

[0033] Take 100g of the active part, pulverize it, pass through an 80-mesh sieve, add 35g of microcrystalline fiber and 5g of magnesium stearate, mix well, make granules, press into tablets, and coat with film.

Embodiment 3

[0035] Take 50g of the active part, pulverize it, pass through an 80-mesh sieve, add 40g of starch, 5g of sucrose powder, and an appropriate amount of ethanol, mix well, make granules, and dry to obtain the product.

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PUM

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Abstract

The invention provides a process for preparation of active portion of scutellaria decoction for curing ulcerative colitis and application of obtained product. According to modern traditional Chinese medicine extracting technology, the active portion of scutellaria decoction of the invention is infiltrated and extracted in alcoholic solution, concentrated through macroreticular absorbing resin, and dried and the like. The total contents of flavone and saponins components in the obtained active portion of scutellaria decoction can reach more than 50%. Experimental study shows that the active portion of scutellaria decoction of the invention has the function of anti-ulcerative colitis.

Description

technical field [0001] The invention relates to a method for extracting and preparing an active part of Huangqin Decoction for treating ulcerative colitis and an application of the obtained product, and belongs to the technical field of extraction methods for active parts of traditional Chinese medicine compound. Background technique [0002] Huangqin Decoction originated from "Treatise on Febrile Diseases" written by Zhang Zhongjing of the Han Dynasty. Huangqin Decoction is composed of Scutellaria baicalensis, peony, licorice, and jujube, which can clear away heat and stop dysentery, and neutralize pain. It is used to treat damp-heat diarrhea, abdominal pain and diarrhea, rapid or unpleasant diarrhea, and scorching heat in the anus. [0003] The effectiveness and safety of Huangqin Decoction have been clinically tested for thousands of years, and it is true and reliable. It is clinically used for dysentery, acute gastritis, enteritis, infantile diarrhea, gastrointestinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61P1/12A61P1/04A61P1/00A61K125/00
Inventor 黄芸崔力剑王永立李云鹏窦玉红赵丁刘伟娜詹文红
Owner HEBEI MEDICAL UNIVERSITY
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