A high-efficiency leather shoes mildew resistant antimicrobial sustained-release agentia and preparation method thereof

Abstract

The invention relates to a preparation method of a high-efficiency anti-mildew and anti-bacterial slow-release agent for leather shoes. The present invention selects the mixture of thiocyanate and isothiazolinone to form the high-efficiency leather shoes mildew-proof and antibacterial agent. The agent has the characteristics of low toxicity, high efficiency, and broad spectrum, and can be widely used in various fields such as leather, export leather shoes, wood, coatings, etc., and is an environmentally friendly high-efficiency anti-mold and antibacterial agent. Compared with the original antifungal agent, the prepared agent has enhanced its water solubility by utilizing the excellent inclusion and sustained release effect of cyclodextrin on drugs, as well as the natural biocompatibility of cyclodextrin and leather. , The second is that the agent has a slow-release effect, which can greatly prolong the action time of the anti-fungal agent; the third is to reduce the corrosiveness, toxicity and irritating odor of the anti-fungal agent.

Description

technical field

[0001] The invention relates to an anti-mildew and anti-bacterial agent for leather shoes, in particular to a high-efficiency anti-mildew and anti-bacterial slow-release agent for leather shoes and a preparation method thereof. Specifically, it relates to a method for preparing a high-efficiency anti-mold and anti-bacterial slow-release agent for leather shoes by using a food-grade substance β-cyclodextrin to include several high-efficiency broad-spectrum anti-fungal agents. Background technique

[0002] my country is a big leather producer and a big exporter of leather shoes. According to statistics in 2005, the leather industry can earn more than 12 billion US dollars for the country's exports every year. my country's annual output of leather shoes is about 2.5 billion pairs, accounting for 40% of the world's total output of leather shoes, ranking first in the world. The raw hides used in tanning production are rich in protein, f...

Examples

Embodiment 1

[0016] Example 1: First dissolve β-cyclodextrin in water at 50°C to make a saturated solution, then add the mixture of TCMTB and OIT while maintaining the temperature while stirring constantly, the mass ratio of TCMTB:OIT is 60:40 , carry out sufficient inclusion reaction for 90 minutes; after stopping the reaction, let the solution stand at 0°C for 24 hours, then filter, wash and dry the precipitate, and finally process it into tablets.

Embodiment 2

[0017] Example 2: first dissolve β-cyclodextrin in water at 60°C to make a saturated solution; maintain the temperature and add the mixture of TCMTB and OIT while stirring constantly, the mass ratio of TCMTB:OIT is 80:20, The inclusion reaction was carried out for 85 minutes; after the reaction was stopped, the solution was left to stand at 3°C ​​for 24 hours, and the precipitate was filtered, washed, dried, and finally processed into a powder.

Embodiment 3

[0018] Example 3: First, dissolve β-cyclodextrin in water at 55°C to make a saturated solution; maintain the temperature and add a mixture of TCMTB and OIT while stirring constantly, the mass ratio of TCMTB:OIT is 95:5, The inclusion reaction was carried out for 95 minutes; after the reaction was stopped, the solution was left to stand at 1° C. for 24 hours, and the precipitate was filtered, washed, dried, and finally processed into tablets.

technical field

[0001] The invention relates to an anti-mildew and anti-bacterial agent for leather shoes, in particular to a high-efficiency anti-mildew and anti-bacterial slow-release agent for leather shoes and a preparation method thereof. Specifically, it relates to a method for preparing a high-efficiency anti-mold and anti-bacterial slow-release agent for leather shoes by using a food-grade substance β-cyclodextrin to include several high-efficiency broad-spectrum anti-fungal agents. Background technique

[0002] my country is a big leather producer and a big exporter of leather shoes. According to statistics in 2005, the leather industry can earn more than 12 billion US dollars for the country's exports every year. my country's annual output of leather shoes is about 2.5 billion pairs, accounting for 40% of the world's total output of leather shoes, ranking first in the world. The raw hides used in tanning production are rich in protein, f...

Examples

Embodiment 1

[0016] Example 1: First dissolve β-cyclodextrin in water at 50°C to make a saturated solution, then add the mixture of TCMTB and OIT while maintaining the temperature while stirring constantly, the mass ratio of TCMTB:OIT is 60:40 , carry out sufficient inclusion reaction for 90 minutes; after stopping the reaction, let the solution stand at 0°C for 24 hours, then filter, wash and dry the precipitate, and finally process it into tablets.

Embodiment 2

[0017] Example 2: first dissolve β-cyclodextrin in water at 60°C to make a saturated solution; maintain the temperature and add the mixture of TCMTB and OIT while stirring constantly, the mass ratio of TCMTB:OIT is 80:20, The inclusion reaction was carried out for 85 minutes; after the reaction was stopped, the solution was left to stand at 3°C ​​for 24 hours, and the precipitate was filtered, washed, dried, and finally processed into a powder.

Embodiment 3

[0018] Example 3: First, dissolve β-cyclodextrin in water at 55°C to make a saturated solution; maintain the temperature and add a mixture of TCMTB and OIT while stirring constantly, the mass ratio of TCMTB:OIT is 95:5, The inclusion reaction was carried out for 95 minutes; after the reaction was stopped, the solution was left to stand at 1° C. for 24 hours, and the precipitate was filtered, washed, dried, and finally processed into tablets.