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Method of marking composition for oral administration

A marking method and composition technology, applied in the field of identification marking, can solve the problems of adhesion, insufficient information of the marking sheet, smudged printing on the tablet, etc., and achieve the effect of high stability

Inactive Publication Date: 2008-05-21
EISIA R&D MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the above-mentioned conventional methods, such as the transfer printing method, are easily affected by the surface state of the tablet or capsule, the atmosphere of the printing place, etc., and the management is very cumbersome in order to stably and clearly print
In addition, in the inkjet printing method, when the ink is not sufficiently dry, smudges or blurred printing may occur on the tablet, which will also affect the appearance quality.
Furthermore, in the marking method, since tablets or capsules have spherical surfaces in many cases, the range that can be printed on the tablet surface, or the number and size of characters that can be printed, or the shape of graphics is limited, and the amount of information provided by the marking sheet may not be sufficient. , similarly, in the engraving method, a dedicated pestle must be prepared for each product
In addition, due to the difference in the shape of the marking, sometimes it is easy to cause sticking, the marking part is missing, or the marking part is worn out in the process after film production, resulting in an increase in the defect rate in the visual inspection, etc.
Or, the engraved part may be missing in the distribution process, which not only reduces the identification, but also affects the quality

Method used

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  • Method of marking composition for oral administration
  • Method of marking composition for oral administration
  • Method of marking composition for oral administration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] (Example 1) tablet

[0096] Mix 80g of lactose, 20g of cornstarch, 0.5g of magnesium stearate, 1g of titanium oxide or 0.2g of yellow ferric oxide, and compress it with a tablet machine or an autograph material tester to obtain tablets.

[0097] Using a laser device (Photonics Industries International, Inc.) shown in Table 1, 100 tablets spread over a 10 cm x 10 cm disk were irradiated with laser light under the conditions shown in Table 1. The result was tablets with excellent visible markings when containing titanium oxide or yellow ferric oxide. On the other hand, its surface is not etched.

Embodiment 2

[0098] (Example 2) tablet

[0099] Mix 80g of lactose, 20g of cornstarch, 0.5g of magnesium stearate, 0.01g of titanium oxide or 0.006g of yellow ferric oxide, and compress it with a tablet machine or an automatic plotter material testing machine to obtain tablets. The above samples were marked using the laser device and irradiation conditions shown in Table 1. As a result, discoloration was observed, resulting in a poorly visible mark.

[0100] [Table 1]

[0101] laser name

[0102] Manufacturer: Photonics Industries International, Inc.

Embodiment 3

[0108] (embodiment 3) soft capsules

[0109] A soft capsule with a gelatin coating layer was prepared by a rotational molding method, and the gelatin coating layer contained 20 parts by mass of concentrated glycerin, 10 parts by mass of D-sorbitol and 1 part by mass of titanium oxide relative to 100 parts by mass of gelatin. Adopt the laser device shown in Table 1 and the irradiation condition, mark text E268 to this soft capsule (white) along the major diameter axis direction of soft capsule. As a result, a gray soft capsule with an excellent visibility mark was obtained. On the other hand, an attempt to mark the same characters with a carbon dioxide laser (ML-G9300 series manufactured by KEYENCE; 1060nm) was able to form white characters on the surface of the soft capsule through foaming, but the visibility of the white characters on a white base was poor.

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Abstract

It is intended to provide a marking method by which a highly distinguishable composition for oral administration (for example, a drug or a food) can be obtained without worsening the qualities of the composition for oral administration and which has a high productivity. Namely, a method of marking a composition for oral administration which comprises the step of dispersing a color change-inducing oxide in the composition for oral administration and the step of scanning the surface of the composition for oral administration with a laser beam of from 200 nm to 1100 nm in wavelength and from 0.1 W to 50 W in average output to thereby aggregate particles of the color change-inducing oxide and induce the color change. The color change-inducing oxide to be used herein is at least one member selected from the group consisting of titanium oxide, yellow iron sesquioxide and iron sesquioxide.

Description

technical field [0001] The present invention relates to a method for applying an identification mark on the surface of an oral composition such as medicine or food. Background technique [0002] For pharmaceutical compositions for oral use such as tablets and capsules, not only the packaging container but also the preparation itself are required to be identifiable in order to prevent drug dispensing and medication errors. However, the identification is limited only by the shape and color of the tablet or capsule. Therefore, it is necessary to further apply a mark on the surface of the tablet or capsule to improve the identification. For example, transfer printing in which characters and the like are directly printed on the surface of film-coated tablets or capsules using a rubber roller, or inkjet printing in which dot printing inks are used. Alternatively, in the case of uncoated tablets, a method of stamping a tablet with unevenness on it has been used for a long time. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/44B41M5/26
CPCB41M5/26A61K9/2866A61K9/2072A61K9/0056A61K9/2009A61K9/4883A61K9/20
Inventor 桃井和久
Owner EISIA R&D MANAGEMENT CO LTD