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Chinese medicine composition for treating early and medium-term chronic renal failure

A technology of composition and renal function, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of no breakthrough progress in the medical field, and achieve the effect of avoiding heavy economic burden, obvious curative effect, large social and economic benefits

Inactive Publication Date: 2011-04-06
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as far as how to delay the process of CRF, there has been no breakthrough in the medical field

Method used

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  • Chinese medicine composition for treating early and medium-term chronic renal failure
  • Chinese medicine composition for treating early and medium-term chronic renal failure
  • Chinese medicine composition for treating early and medium-term chronic renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Chinese medicine raw materials: Codonopsis 5g, Xianlingpi 5g, Salvia miltiorrhiza 5g, rhubarb 5g, perilla 5g, ginger pinellia 3g, coptis 2g, peach kernel 5g, Chuanxiong 5g, Cordyceps mycelium 2g.

[0052] Take the above-mentioned medicines of Cordyceps mycelium and mix them, decoct twice, each time for 1 hour, add water to a total of 8-10 times the amount, combine and concentrate the decoctions to a specific gravity of 1.08-1.2 (80°C), and then carry out purification treatment , add 95% ethanol to make the alcohol content to be 50%, place it for precipitation, take the supernatant the next day to recover ethanol, concentrate to a specific gravity of about 1.3, add Cordyceps mycelia, add common auxiliary materials according to the conventional method, and make solid oral dosage forms such as Granules, tablets, capsules, mixtures or powders.

[0053]Among them, add dextrin, spray dry to make fine powder, and make granules through dry granulation; or add sodium hydroxymeth...

Embodiment 2

[0055] Get the following Chinese medicine raw materials of weight ratio: Codonopsis 60g, 45g of fairy spleen, 60g of salvia miltiorrhiza, 30g of processed rhubarb, 30g of perilla, 20g of ginger pinellia, 10g of rhizoma coptis, 20g of peach kernel, 25g of Chuanxiong, 10g of Cordyceps mycelium, adopt embodiment 1 The method for preparing granules, tablets, capsules, mixtures or powders.

Embodiment 3

[0057] Get the following Chinese medicine raw materials of weight ratio: Codonopsis 10g, xianlingpi 10g, salvia miltiorrhiza 10g, rhubarb 10g, perilla 10g, ginger pinellia 5g, berberine 3g, peach kernel 10g, chuanxiong 10g, cordyceps mycelium 3g, adopt embodiment 1 The method for preparing granules, tablets, capsules, mixtures or powders.

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Abstract

The invention belongs to the traditional medicine technical field, which relates to a traditional Chinese medicine composition for curing early and intermediate chronic renal failure. Under the guidance of a traditional Chinese medicine theory that 'interior accumulation is blood stasis' and 'chronic diseases transforming to collaterals is blood stasis', with the treatment principle of differentiation of symptoms and sighs, differentiation of channels, and based on the principle of strengthening body resistance and reducing turbidity, promoting blood circulation and removing blood stasis, the invention adopts traditional medicine such as lanceolata, epicedium, salvia miltiorrhizae, prepared rhubarb, perilla, peach kernel and the like, which are made into the compositions. Confirmed by clinical and animal experiments, the invention has the renal protecting functions of improving clinical symptoms of patients with early and intermediate chronic renal failure, reducing retention of metabolites of bodies, improving anemia, adjusting lipid and calcium-phosphorus metabolism, reducing the expression of fibrosis factors in nephridial tissues, preventing and treating glomerulosclerosis, lightening renal tubule damage and renal interstitial inflammatory cell infiltration and delaying renal fibrosis. The invention has the advantages of safety, efficiency and low cost, which is applied tothe long-term medication for patients with early and intermediate chronic renal failure.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating early and middle stage chronic renal failure. Background technique [0002] Chronic Renal Failure (CRF) for short, refers to the chronic progressive damage of the kidney caused by various reasons, making it unable to maintain basic functions, clinically characterized by retention of metabolites, disturbance of water, electrolyte and acid-base balance And a group of syndromes characterized by abnormalities in certain endocrine functions. [0003] Clinically, renal diseases with different etiologies have slightly different rates of developing into end-stage renal disease (ESRD) after renal function decompensation, but the overall trend has no difference. It is generally believed that the renal lesions are potentially progressive, mostly irreversible, and may develop progressively and aggravate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61K36/9068A61K9/14A61K9/16A61K9/20A61K9/48A61K9/00A61P13/12
Inventor 王琛郑平东何立群王丽莉高建东侯卫国
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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