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Double hydrogen arteannuic plain guagui slice and preparing method thereof

A technology of dihydroartemisinin and guaquine tablets, which is applied in pill delivery, anti-infective drugs, drug combinations, etc., can solve problems such as inconvenient taking, and achieve the effects of convenient taking, high yield and low cost

Inactive Publication Date: 2008-06-18
ZHUHAI HUAAO IMPORT & EXPORT CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in the prior art, these two raw materials are not combined to make a preparation, and patients need to purchase them separately when taking them, which is also inconvenient to take.

Method used

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  • Double hydrogen arteannuic plain guagui slice and preparing method thereof

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preparation example Construction

[0021] The preparation method of dihydroartemisinin guaquine tablet of the present invention is carried out according to the following steps:

[0022] (1) Take the dihydroartemisinin, the piperaquine phosphate, and the sodium carboxymethyl starch in the weight ratio and pass through a 100-mesh sieve for subsequent use;

[0023] (2) Get the starch, the hydroxypropyl cellulose, the dextrin, and the magnesium stearate in the weight ratio and pass through a 100-mesh sieve for subsequent use;

[0024] (3) mix the described guarquine phosphate, the starch, and the dextrin uniformly, and use the hydroxypropyl cellulose solution as the binding agent to make the mixed medicinal powder into a soft material (the soft material should be grasped into agglomerates) , touch it and disperse), pass through a 14-mesh sieve to make wet granules;

[0025] (4) After drying the wet granules, pass through a 16-mesh sieve to make dry granules;

[0026] (5) fully mixing the dihydroartemisinin, the s...

Embodiment 1

[0029] In the present embodiment, the weight of each raw material is respectively:

[0030] Dihydroartemisinin 40g, guavaquine phosphate 320g, starch 70g, dextrin 20g, sodium carboxymethyl starch 30g, hydroxypropyl cellulose 6g, magnesium stearate 3g, can prepare 1000 dihydroartemisinin guaquine tablets , each tablet contains the active ingredient dihydroartemisinin 40mg + guaiquine phosphate 320mg.

[0031] How to take: take orally. The total dosage for adults is 8 tablets, once in the morning and evening, 2 tablets each time. Children should be reduced according to the doctor's advice.

Embodiment 2

[0033] In the present embodiment, the weight of each raw material is respectively:

[0034] Dihydroartemisinin 40g, guaquine phosphate 320g, starch 90g, dextrin 30g, sodium carboxymethyl starch 35g, hydroxypropyl cellulose 10g, magnesium stearate 5g, dihydroartemisinin guaquine tablets 1000 pieces can be prepared , each tablet contains the active ingredient dihydroartemisinin 40mg + guaiquine phosphate 320mg.

[0035] All the other are the same as embodiment one.

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Abstract

The invention discloses a piperaquine dihydroartemisinin tablet and the related preparation method, aiming at providing a piperaquine dihydroartemisinin tablet which is convenient to take and is prepared with dihydroartemisinin and piperaquine phosphate. The invention is made of 40 portions of dihydroartemisinin, 320 portions of piperaquine phosphate, 70 to 90 portions of starch, 20 to 30 portions of dextrin, 30 to 35 portions of sodium carboxymethyl starch, 6 to 10 portions of lhydroxypropyl cellulose and 3 to 5 portions of magnesium stearate (based on weight). The invention has the advantages of high finished product rate and low cost.

Description

technical field [0001] The invention relates to a dihydroartemisinin guaquine tablet and a preparation method thereof. Background technique [0002] Dihydroartemisinin, chemical name: (3R, 5aS, 6R, 8aS, 9R, 12S, 12aR)-octahydro-3,6,9trimethyl-3,12-oxo-12H- Pyrano[4,3-j]-1,2-benzodisepin-10(3H)ol. Molecular formula: C 15 h 24 o 5 [0003] Its chemical structural formula is as follows: [0004] [0005] Dihydroartemisinin is a derivative of artemisinin and the active substance of artemisinin in the body. It has a strong and rapid killing effect on the erythrocytic stage of Plasmodium, and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is mainly to interfere with the mitochondrial function of the surface membrane of Plasmodium. Artemisinin changes the membrane structure of Plasmodium by affecting the ultrastructure of the erythrocytic stage of Plasmodium. Due to the effect on the food bubble membrane, the nutrient intake of ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/357A61K31/4706A61P33/06
Inventor 于寅辰
Owner ZHUHAI HUAAO IMPORT & EXPORT CORP
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