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Application of clematis chinensis in preparing medicament for treating nausea and emesis

A technology of nausea, vomiting, and Wei Lingxian, which is used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of inability to accept normal treatment, affect disease control, and be expensive, and achieve improvement in the condition, low treatment costs, and toxicity Effects with few side effects

Inactive Publication Date: 2008-07-09
张旭梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the dosage is less than 1 catties, the curative effect is poor; the effective rate of two courses of treatment is higher than that of one course of treatment
The most common adverse reactions are headache, constipation, abdominal distension, diarrhea, drowsiness, etc. Toxic side effects such as sedation, hallucinations, hallucinations, elevated blood pressure, and changes in electrocardiogram may also occur to varying degrees, and it is ineffective for delayed vomiting
In addition, some of the above-mentioned drugs are expensive, and most patients cannot receive normal treatment due to unaffordable financial conditions, which seriously affects the control of the disease.

Method used

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  • Application of clematis chinensis in preparing medicament for treating nausea and emesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Take 500g of Clematis, sort out the impurities, screen and wash, dry and crush into coarse powder, soak in 2000mL60% ethanol for 2h, extract twice with alcohol, combine the extracts, recover ethanol, concentrate into a clear paste with a relative density of 1.12 , add auxiliary materials to make oral disintegrating soft capsules, each capsule contains 3-5g of crude drug.

Embodiment 2

[0086] Take 500g of Clematis, pick out impurities, screen and wash, dry and crush into coarse powder, take the prepared 1% ginger juice and soak for 15min, then dry, add 1000mL of pure water, extract with steam for 60min, filter, then add 1000mL of purified water, extract with steam for 50min, filter, combine the filtrates, concentrate to a concentrated solution containing 2g of crude drug per milliliter, adjust the pH value to 6-7, let it stand for 24h, fill it into a 10mL / bottle of oral liquid, and follow the conventional preparation Sterilize.

Embodiment 3

[0088] Take 500g of Clematis clematis, sort out impurities, screen and wash, dry and crush into coarse powder, soak in 1% ginger juice for 10min, dry, extract twice with 1000mL of pure water under reduced pressure, combine the extracts, Concentrate into a clear paste with a relative density of 1.14 (50°C), use sucrose fine powder as an auxiliary material, make granules containing 1-2 g of crude drug per 1 g, pack into bags, 10 g per bag, and sterilize according to conventional preparations.

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Abstract

The present invention relates to the application of Chinese medicine clematis in the preparation of medicine for curing naupathia and vomit, in particular to the application in the preparation of medicine for curing naupathia and vomit caused by radiotherapy and chemotherapy. Clematis can better relax smooth muscles, change stomach qi, reduce stimulus injuries to gastric mucosa caused by radiotherapy and chemotherapy medicines, effectively cure and prevent vomit caused by radiotherapy and chemotherapy and intractable naupathia and vomit caused by various reasons, effectively and timely inhibit gastrointestinal mucosal cells from releasing excessive 5-HT, dopamine and other neural substances, and control naupathia and vomit caused by vomiting center. The present invention has the advantages of quick and high curing effect, cure rate up to more than 95 percent and significant curing effect to various acute and slow vomits, which can increase the appetite of patients, strengthen body resistance and improve disease conditions.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine Clematis clematis, and its application in the preparation of medicines for treating nausea and vomiting, especially its application in the preparation of medicines for treating nausea and vomiting caused by radiotherapy and chemotherapy. Background technique [0002] Radix Clematis Chinensis (Radix Clematidis Chinensis), which belongs to the genus Clematis of the Ranunculaceae Ranunculaceae, is the root and rhizome of the Ranunculaceae plant Clematis. Also known as Nengxiao, Iron-footed Clematis, Lingxian, Black-footed Clematis, Iron Broom, Tiger Beard, Green Dragon Beard, etc. It mainly contains protoanemonin, anemonin, ranunculin, clematoside, and also contains a variety of saponins whose aglycone is oleanolic acid. Warm in nature, pungent and salty in taste, returns to bladder and liver channels. Efficacy Dispelling rheumatism, dredging channels and collaterals, elimi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61P1/08A61K125/00
Inventor 张旭梅张校科张馨
Owner 张旭梅
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