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Antibacterium compounds containing clindamycin hydrochloride

A technology of clindamycin hydrochloride and antibacterial composition, which is applied in the field of antibacterial compositions containing clindamycin hydrochloride palmitate, can solve the problems of no antibacterial activity, limited antibacterial application, etc., and achieves widening antibacterial scope and application. promising effect

Active Publication Date: 2010-06-02
GUANGZHOU YIPINHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But clindamycin palmitate hydrochloride does not have antibacterial activity to many Gram-negative bacteria, such as Escherichia coli, Klebsiella and Pseudomonas aeruginosa etc. do not have antibacterial activity, this Greatly limit its antibacterial application

Method used

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  • Antibacterium compounds containing clindamycin hydrochloride
  • Antibacterium compounds containing clindamycin hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 ointment preparation

[0019] The components and contents are as follows:

[0020] Clindamycin Palmitate Hydrochloride 1g

[0021] Manidipine 4g

[0022] Vaseline 80g

[0023] Liquid paraffin 9g

[0024] Lanolin 8g

[0025] Pure water 1.5g

[0026] According to the above components and contents, add epinastine hydrochloride and prednisolone into pure water to dissolve, add vaseline-liquid paraffin-lanolin ointment base, mix evenly, separate bacteria, and pack separately to obtain the finished product.

Embodiment 2

[0027] Embodiment 2 capsule preparation

[0028] The components and contents are as follows:

[0029] Clindamycin Palmitate Hydrochloride 1g

[0030] Manidipine 2.5g

[0031] Cyclodextrin 5g

[0032] Microcrystalline Cellulose 60g

[0033] Calcium hydrogen phosphate 20g

[0034] Carboxymethyl Starch Sodium 25g

[0035] Stevia 25g

[0036] Magnesium Stearate 5g

[0037] Micronized silica gel 10g

[0038] Starch lactose 100g

[0039] The above-mentioned various raw materials are dried at low temperature, pulverized, passed through a 100-mesh fine sieve, mixed uniformly, made into a powder, and uniformly granulated by a granulator, and filled into a hollow capsule with a capsule filler after sterilization to obtain a capsule. Capsules contain 0.35 g of granules.

Embodiment 3

[0040] Embodiment 3 antibacterial experiment

[0041] 1 g of clindamycin palmitate hydrochloride and 2.5 g of manidipine are prepared into a combined preparation, and the production process of conventional freeze-dried powder injection is carried out.

[0042] The combined preparation of the invention has been proved by in vitro tests that its antibacterial activity is stronger than that of clindamycin palmitate hydrochloride, and its antibacterial range is wider.

[0043] The antibacterial effect (MIC of table 1 combination preparation and clindamycin hydrochloride palmitate 90 mg / L)

[0044] bacteria

combination preparation

Clindamycin Palmitate Hydrochloride

Staphylococcus aureus

1.2

2.5

Staphylococcus epidermidis

10

18

Streptococcus pneumoniae

5

8

Escherichia coli

2

-

Klebsiella

0.1

-

Pseudomonas aeruginosa

0.2

-

Propionibacterium

6

5

...

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Abstract

The invention discloses an antibacterial composition containing clindamycin palmitate hydrochloride; the antibacterial composition containing clindamycin palmitate hydrochloride of the invention comprises the following components by weight portions: the clindamycin palmitate hydrochloride of 1 portion and the manidipine of 2 to 4 portions. As the clindamycin palmitate hydrochloride has good anti-bacteria activity while the Manidipine has no anti-bacteria activity under the present discovery, the invention combines the clindamycin palmitate hydrochloride with the Manidipine in certain proportional range so that the clindamycin palmitate hydrochloride and the Manidipine can have the function of the cooperative interaction. Without changing the original anti-bacteria activity of the clindamycin palmitate hydrochloride, the combined composition also has the anti-bacteria activity to most of gram-negative bacteria which greatly extends the antibacterial range of the clindamycin palmitate hydrochloride with wide application outlook.

Description

technical field [0001] The invention relates to the field of antibacterial drugs, in particular to an antibacterial composition containing clindamycin hydrochloride palmitate. Background technique [0002] The chemical name of clindamycin palmitate hydrochloride is 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7(S)-chloro- 6,7,8-trideoxy-L-threo-α-D-galactopyranoside-2-palmitate hydrochloride, formula C 34 h 63 ClN 2 o 6 S HCL, structural formula such as formula (I), [0003] [0004] Clindamycin palmitate hydrochloride is the prodrug of clindamycin, and its pharmacology and toxicology data research shows that after entering the body, it is rapidly metabolized into clindamycin and exerts its activity. Clindamycin palmitate hydrochloride has antibacterial activity against many Gram-positive bacteria, Streptococcus, Bacillus, etc., and also has certain antibacterial activity against many anaerobic bacilli, Chlamydia, Mycoplasma, and Toxoplasma gondii. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61P31/04A61K31/496
Inventor 王勇
Owner GUANGZHOU YIPINHONG PHARMA
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