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Pharmaceutical composition containing diabetosan and vildagliptin and preparation thereof

A technology of metformin hydrochloride and its composition, which is applied in the field of medicine and can solve the problems of lack of insulin, lack of compound metformin hydrochloride and vildagliptin related literature and patent reports, etc.

Inactive Publication Date: 2008-08-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ability to produce insulin in patients with type 2 diabetes is not completely lost, and some patients even produce too much insulin in their bodies. However, due to the enhanced insulin resistance of the body, the effect of insulin is not obvious. Therefore, insulin deficiency in patients is a kind of relative lack
[0008] Through the search, there are no relevant literature and patent reports on compound metformin hydrochloride and vildagliptin

Method used

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  • Pharmaceutical composition containing diabetosan and vildagliptin and preparation thereof
  • Pharmaceutical composition containing diabetosan and vildagliptin and preparation thereof
  • Pharmaceutical composition containing diabetosan and vildagliptin and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 metformin hydrochloride and vildagliptin tablet

[0029] prescription:

[0030]

[0031]

[0032] Preparation:

[0033] Pass vildagliptin and microcrystalline cellulose through 80-mesh sieve respectively, mix evenly, and mix them with metformin hydrochloride in an equal amount incremental method, stir well to make them even, and set aside; add 50% ethanol solution to the mixed powder, make soft material, granulated with a 24-mesh sieve, dried, granulated with a 20-mesh sieve, added micropowder silica gel and CMS-Na, mixed evenly, and pressed into tablets with a suitable die to obtain the product.

[0034] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 2

[0035] Embodiment 2: metformin hydrochloride and vildagliptin capsules

[0036] prescription:

[0037]

[0038] Preparation:

[0039] Pass vildagliptin and metformin hydrochloride through an 80-mesh sieve, mix uniformly according to the method of equal volume addition, add magnesium stearate, mix uniformly, pack separately, and obtain the product.

[0040] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 3

[0041] Example 3: Metformin Hydrochloride and Vildagliptin Chewable Tablets

[0042] prescription:

[0043]

[0044] Preparation:

[0045] Vildagliptin, metformin, xylitol, mannitol and other raw and auxiliary materials were passed through 80 mesh sieves respectively, mixed uniformly by the method of equal increase, and 2% PVP-k30 ethanol solution was added to make soft materials, granulated with 16 mesh sieves, Dried, sieved with a 20-mesh sieve, added other flavoring agents, sweeteners, and glidants, mixed evenly, and pressed into tablets.

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PUM

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Abstract

The invention relates to medical composition containing metformin and Vildagliptin and a preparation method thereof. The medical composition is formed by taking metformin chloride and Vildagliptin as medical active components and blending with pharmaceutically acceptable auxiliary materials; the invention adopts the metformin chloride and Vildagliptin as materials and adds auxiliary materials with some special kinds and proportions to prepare and develop diversified oral preparations such as tablets, capsules, granules, dispersible tablets, chewable tablets, buccal tablets, effervescent tablets, effervescent granules according to the technical method of the invention. The medical composition of the invention can be used for treating diabetes type II that can not be properly cured by alimentary control and sports and also for diabetes type II that can not be controlled by simply using metformin chloride or Vildagliptin.

Description

technical field [0001] The invention relates to a pharmaceutical composition with metformin hydrochloride and vildagliptin as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a syndrome of glucose, protein and lipid metabolism disorders caused by insulin deficiency or insulin cell metabolism defects. Proper control can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels, and heart, and eventually lead to blindness, lower limb gangrene, uremia, cerebral apoplexy or myocardial infarction, and even life-threatening. Diabetes is a common disease. With the improvement of living standards, the incidence of diabetes is increasing year by year. The prevalence of diabetes in developed countries has reached 5% to 10%, and the prevalence in my country has reached 3%. [0003] Type 2 diabetes, also known as ...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K9/16A61K9/20A61K9/46A61K9/48A61P3/10A61K31/155
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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