Guacetisal dry-mixing suspending agents and method of preparing the same

A technology of guacetila and dry suspensions, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central pain relievers, etc., can solve the problems of not giving further prompts and the like

Active Publication Date: 2008-09-03
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But, how to obtain the Guacetia willow dry suspension with more excellent dispersion effect and stability by the sedimentation volume ratio adjustment of the s

Method used

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  • Guacetisal dry-mixing suspending agents and method of preparing the same
  • Guacetisal dry-mixing suspending agents and method of preparing the same
  • Guacetisal dry-mixing suspending agents and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] prescription:

[0075] Guacamole 165g

[0076] Sucrose 820g

[0077] Hypromellose (HPMC) 10g

[0078] Sodium dodecyl sulfate (SDS) 5g

[0079] Appropriate amount of fresh milk essence

[0080]

[0081] Made in packs of 1000

[0082] Preparation:

[0083] (1) Take the prescribed amount of Guaxitilian and grind it through a 200-mesh sieve for subsequent use;

[0084] (2) get each auxiliary material of prescription and pulverize through 120 mesh sieves, and set aside;

[0085] (3) Mix the medicine and the auxiliary material evenly to obtain the intermediate;

[0086] (4) Determination of intermediate content, calculation of filling volume, inspection and packaging.

[0087] The dosages of active pharmaceutical ingredients and pharmaceutical adjuvants in Examples 2, 3, 4, 5, 6, and 7 are shown in the attached table, and the preparation method is the same as in Example 1.

[0088] schedule

[0089] Example 2

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Abstract

The invention relates to a guacetisal dry suspension, the formula of which for preparing 1,000 bags comprises the following raw materials (by weight parts) guacetisal 160-170, hydroxypropyl methyl cellulose 5-10, sodium lauryl sulfate 5-10, sucrose 815-820, and a proper amount of fresh milk essence, wherein the sodium lauryl sulfate is used as a wetting agent for facilitating suspension. The guacetisal dry suspension has the advantages of good settling volume ratio, long suspension state keeping time, good stability, and good mouthfeel; and is more suitable for administration by children and patients suffering from dysphagia.

Description

technical field [0001] The invention relates to a new drug preparation, in particular to a dry suspension of guacetidine. Background technique [0002] The molecular formula of Guaxitilian is C 16 h 14 o 5 , the molecular weight is 286.29, and the chemical name is 2-acetoxybenzoic acid-(2-methoxy)phenyl. Its chemical structural formula is as follows: [0003] [0004] Guacitilis is an ester formed by combining aspirin and guaiacol. It has antipyretic, analgesic and anti-inflammatory effects, antitussive and expectorant effects of both. It is clinically used to treat colds, influenza, tracheitis and bronchitis. Inflammation, etc., with definite curative effect and little side effects. Guacityl was first successfully developed in 1979 by the Italian Bayer company, and it was first launched in January 1981. At present, many countries in Western Europe use it as a new drug for the treatment of upper respiratory tract infections. The foreign commodity names are Balsaceti...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/22A61K47/38A61P29/00A61P11/00
Inventor 刘保起李明华曹传
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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