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Method for preparing non-alkaloids part of subprostrate sophora root

A non-alkaloid and mountain bean technology, which is applied in the field of preparation of the non-alkaloid part of mountain bean root, can solve the problem that the effect is not as obvious as the "Ganyanling injection" prepared by direct extraction with water, and achieve stable substance content Controllable, simple preparation process and low cost

Inactive Publication Date: 2008-10-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, it has also been found clinically that matrine injection or matrine injection made from matrine or oxymatrine monomer, which is the main alkaloid component of Shandou root, does not have the same effect as those prepared by direct extraction with water. "Ganyanling injection" is obvious, which shows that there may be more effective non-alkaloid components in Shandou root to protect the liver and lower enzymes

Method used

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  • Method for preparing non-alkaloids part of subprostrate sophora root

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Take 1000g of 40-mesh to 200-mesh mountain bean root medicinal powder, add 6 times the amount of water for the first time, reflux extraction for 1 hour, and filter.

[0020] The dregs were then reflux extracted with water 4 times the amount of the medicinal material for 1 hour, and then filtered. The combined filtrates were concentrated under reduced pressure to 250 mL. At 4°C, add 95% ethanol to the concentrated solution, stir to adjust the alcohol concentration of the solution to 50%, and let it stand for 6 hours; filter to remove insoluble matter. Concentrate the filtrate to 250mL, and separate it with a cross-linked polystyrene-based strong acid resin, the model of which is 001×7, and elute with deionized water; collect the water eluate until the eluate is neutral and colorless, and concentrate under reduced pressure The eluate is in the form of an extract, dried in a vacuum or freeze-dried into a dry powder, and the non-alkaloid part of the root of the mountain be...

Embodiment 2

[0023] Take 1000g of 40-mesh to 200-mesh mountain bean root medicinal powder, add 10 times the amount of water for the first time, reflux extraction for 2 hours, and filter. The dregs were then reflux extracted with water 6 times the amount of medicinal materials for 1.5 h, and then filtered. The operation was repeated once, and the combined filtrates were concentrated under reduced pressure to 300 mL. At 20°C, add 95% ethanol to the concentrated solution, stir to adjust the alcohol concentration of the solution to 70%, and let it stand for 8 hours; filter to remove insoluble matter. Concentrate the filtrate to 250mL, and separate it with a cross-linked polystyrene-based strong acid resin, the model of which is 001×7, and elute with deionized water; collect the water eluate until the eluate is neutral and colorless, and concentrate under reduced pressure The eluate is in the form of an extract, dried in a vacuum or freeze-dried into a dry powder, and the non-alkaloid part of ...

Embodiment 3

[0026] Take 1000g of 40-mesh to 200-mesh mountain bean root medicinal powder, add 15 times the amount of water for the first time, reflux extraction for 3 hours, and filter.

[0027] The dregs were then reflux extracted with water 8 times the amount of medicinal materials for 1.5 h, and then filtered. The operation was repeated twice, and the combined filtrate was concentrated under reduced pressure to 500 mL. At 30°C, add 95% ethanol to the concentrated solution, stir to adjust the alcohol concentration of the solution to 90%, and let it stand for 10 hours; filter to remove insoluble matter. Concentrate the filtrate to 250mL, and separate it with a cross-linked polystyrene-based strong acid resin, the model of which is 001×7, and elute with deionized water; collect the water eluate until the eluate is neutral and colorless, and concentrate under reduced pressure The eluate is in the form of an extract, dried in a vacuum or freeze-dried into a dry powder, and the non-alkaloid...

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Abstract

The invention discloses a preparation method for the non-alkaloid part of sophorae tonkinensis, which belongs to the technical field of Chinese medicine. The preparation method is as follows: ethanol is added into water regurgitation extract of the sophorae tonkinensis; insoluble substance is precipitated and filtered; filtrate is condensed and carries out column chromatograph separation by the strong acid cationic resin of crosslinked polystyrene series; the filtrate is eluted by water; eluted water is collected and condensed to ointment; and the ointment is decompressed and dried to obtain the non-alkaloid part. The non-alkaloid part contains carbohydrate, organic acid, phenols and saponin and son on. The preparation process of the invention is easy and quick and the cost of preparation is low. In addition, the quality of various substances of the obtained product is stable and controllable. The non-alkaloid part is applied for reducing enzyme and protecting liver, and offers substance base for seeking more efficient non-alkaloid active components.

Description

technical field [0001] The invention relates to a preparation method in the technical field of traditional Chinese medicine, in particular to a preparation method of the non-alkaloid part of the root of the mountain bean root. Background technique [0002] Sophora tonkinensis is the dried root and rhizome of Sophora tonkinensis Gapnep. Its medicine is cold in nature and bitter in taste, and it returns to the lung and stomach meridians. The 2005 edition of the Chinese Pharmacopoeia records that Shandougen has the effects of clearing heat and detoxification, reducing swelling and pharynx. Bean root mainly contains alkaloids, flavonoids, saponins and polysaccharides. Pharmacological experiments show that Shandou root has various pharmacological activities such as anti-tumor, anti-virus, anti-liver damage, and anti-arrhythmia, and according to research reports, most of the alkaloids contained in it are the material basis of these pharmacological activities. Modern researches ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P1/16A61K125/00
Inventor 贾伟赵爱华张媛媛高月求
Owner SHANGHAI JIAO TONG UNIV
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