Preparation of Simotang enema and suppositorium

A technology of four grinding soups and enemas, which is applied in the direction of suppository delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of missing the best time to prevent intestinal adhesions, inconvenient swallowing, taking medicine for the first time in an hour, and taking medicine every other time. Problems such as taking the medicine for the second time in 6 hours, to achieve the effect of reducing intestinal adhesion, therapeutic effect number, and promoting anal exhaust

Inactive Publication Date: 2008-10-08
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The above techniques are all in the oral dosage form, which brings inconvenience to patients who have difficulty swallowing and infants; especially for patients after abdominal surgery, the basis for the formation of intestinal adhesions has been laid within 3 to 6 hours after the operation. Therefore, 3 to 6 hours after the operation Restoring bowel motility as soon as possible is an important item in the prevention of intestinal adhesions
It is the basic medical plan to fast for food and water within a few hours after the operation. There is an oral preparation of Simotang. Generally, surgical patients take the medicine for the first time 12 hours after the operation, and then take the medicine for the second time every 6 hours. The recovery of the patient is helpful, but the best time to prevent intestinal adhesion has been missed

Method used

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  • Preparation of Simotang enema and suppositorium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (a) Take 37.5g of Muxiang, 37.5g of Citrus aurantii, 37.5g of betel nut, 37.5g of black medicine, and the above four medicinal materials, extract 4 times the amount of aromatic water from the medicinal materials by distillation, store them in another container, filter the medicinal liquid, and remove the medicinal residues Add water to decoct twice, each time for 0.5 hours, filter, combine the decoction, concentrate under reduced pressure to a clear paste with a relative density of 1.1 (60-70°C), add ethanol to make the alcohol content reach 75%, refrigerate for 12 hours, filter After passing, the filtrate recovers ethanol until it has no alcohol smell, adds 300ml of water and stirs in an appropriate amount, refrigerates for 12 hours, and filters to obtain a clear paste;

[0043] (b) Get sodium carboxymethyl cellulose 15g and add the aromatic water swelling of item (a) to make glue;

[0044](c) Mix the obtained clear ointment with the mucilage, add 1.5 g of preservative...

Embodiment 2

[0046] (a) Take 37.5g of Muxiang, 37.5g of Citrus aurantii, 37.5g of betel nut, 37.5g of black medicine, and the above four medicinal materials, extract 4 times the amount of aromatic water from the medicinal materials by distillation, store them in another container, filter the medicinal liquid, and remove the medicinal residues Add water and decoct twice, each time for 0.5 hours, filter, combine the decoction, and concentrate under reduced pressure to a clear paste with a relative density of 1.1 (60-70°C);

[0047] (b) Take 6g of carbomer and add 300ml of water, adjust the pH to 7 with 20% sodium hydroxide, stir to make the swelling even, add clear ointment and the aromatic water of item (a) and stir evenly;

[0048] (c) Mix the obtained clear ointment and mucilage, then take 1g of ethyl p-hydroxybenzoate, add 300ml of water, heat to dissolve, add the liquid of clear ointment and mucilage, add water to 2000ml, mix well, and pack into 20ml / bottle.

[0049] The auxiliary mat...

Embodiment 3

[0051] (a) Take 37.5g of Muxiang, 37.5g of Citrus aurantii, 37.5g of betel nut, and 37.5g of black medicine, add water to decoct twice, each time for 0.5 hours, filter, combine the decoction, concentrate to a relative density of 1.10-1.20 (60 °C), the thick paste is dried below 80 °C and crushed into fine powder;

[0052] (b) Take 1800g of mixed fatty acid glycerides, heat to melt, add the fine powder in item (a) when the temperature is 40°C±2°C, stir evenly, pour into the plug mold, and obtain 1000 grains.

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Abstract

The invention relates to an enema and a suppository of Simo decoction of traditional Chinese patent medicine. The preparation method comprises the steps of: adopting costustoot, hovenia dulcis, areca seed and radix linderae as raw materials, boiling the raw materials, ethanol precipitating, adding excipients and preservatives to obtain the enema, or adopting costustoot, hovenia dulcis, areca seed and radix linderae as raw materials, boiling the raw materials, concentrating, drying, grinding, adding suppository matrix to obtain the suppository. The enema and the suppository of the invention have the advantages that the enema and the suppository have the functions of harmonizing stomach and lowering adverse, facilitating qi and removing food retention; the enema and the suppository adopt anus administration method, which are particularly applicable to the penitents and the children who have difficulty in swallowing for usage and can meet the basic treatment methods of banning water and food after abdomen surgery.

Description

technical field [0001] The invention relates to a medicine, in particular to an enema and a suppository for anal administration based on the ingredients of Simotang and changing the dosage form. Background technique [0002] Simo Decoction is a traditional prescription for regulating qi and subduing adverse conditions. It is composed of four medicines: Citrus aurantium Fructus, Woody Fragrance, Wuyao and Betel Nut. In the prescription, Fructus Aurantii is good at regulating qi, reducing swelling, and removing swelling; the woody fragrance is good at relieving pain, and is good at relieving stagnation of qi in the spleen, stomach and large intestine; black medicine can relieve pain and dispel cold; betel nut is good at promoting qi, eliminating stagnation, and breaking stagnation. The 4 medicines are combined to play the functions of harmonizing the stomach, reducing adverse effects, smoothing qi and eliminating accumulation. Indications for infants and young children with s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/02A61K9/10A61K47/38A61K47/32A61K47/14A61P1/14A61P1/10
Inventor 马书太史学文张为胜徐东峰秦承志秦婧李振香
Owner JINAN KANGZHONG PHARMA TECH DEV
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