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Application of cistanche salsa extract in preparing medicament for treating parkinsonism

A technology of Parkinson's disease and Cistanche, applied in the field of Cistanche extract, can solve problems such as undiscovered and delayed disease progression

Inactive Publication Date: 2008-10-29
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The neuroprotective drugs that once aroused great hopes, such as slangiline, have not been found to significantly delay the progression of the disease after large-scale clinical trials

Method used

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  • Application of cistanche salsa extract in preparing medicament for treating parkinsonism
  • Application of cistanche salsa extract in preparing medicament for treating parkinsonism
  • Application of cistanche salsa extract in preparing medicament for treating parkinsonism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Made into tablets, pills, granules, syrups, ointments. In addition to the total glycosides of Cistanche deserticola, flavoring agents can be added as required. The ingredients of the tablets, pills, granules, syrups and ointments include:

[0029] Cistanche total glycosides 5%-90% (weight ratio)

[0030] Flavoring agent 0.1-1% (weight ratio)

[0031] The above-mentioned flavoring agent can be selected from α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), N-LOK modified starch, sucrose, xylitol, high fructose, cyclamate, stevia and One or more of proteoglycans.

Embodiment 2

[0032] Embodiment 2 is made into capsules. The capsules consist of:

[0033] Cistanche total glycosides 15%-30% (by weight)

[0034] Flavoring agent 0.5-10% (weight ratio)

[0035] The above-mentioned corrective agents mainly include: hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), acrylic resin, etc.

Embodiment 3

[0036] Embodiment 3 is made injection, dropping pill. The injection and drop pills include:

[0037] Cistanche total glycosides 20%-30% (by weight)

[0038] Solvent amount

[0039] 4. Mechanism of treatment

[0040] Therapeutic mechanism of Cistanche deserticola extract in the preparation of medicament for treating Parkinson's disease

[0041] Contemporary TCM scholars usually use the traditional method of "syndrome differentiation and seeking cause" to deduce the TCM mechanism of Parkinson's disease. Most scholars believe that the pathogenesis of Parkinson's disease is characterized by deficiency in origin and excess in superficiality. There are many reasons for this deficiency, and the most important ones are roughly as follows: (1) age factor: Parkinson's disease is more common in the elderly, and Zhou's [1，2] It is believed that after middle age, when the yin qi is self-half, there will be physiological weakness such as liver and kidney deficiency, combined with fatig...

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Abstract

The invention relates to the application of total cistanchis glycosides extracted from desertliving cistanche in the preparation of medicaments for treating Parkinson disease. Extract of the desertliving cistanche is prepared by the following method: 70 percent of ethanol is used for twice reflux after the desertliving cistanche is sliced, supernatant extraction is carried out, extract liquid is carried out the water floatation, thus obtaining supernatant liquid; the supernatant liquid passes through a macroporous resin, water is firstly used for elution, methanol is then used for elution, wherein, after using the methanol for elution, the solution is evaporated, after the evaporation, the products are dissolved by using n-butyl alcohol, thus obtaining water phase and alcohol phase; the alcohol phase is evaporated and then anhydrous ethanol is used for refining, thus obtaining the total cistanchis glycosides, which are the extract of the desertliving cistanche. The total cistanchis glycosides extracted from desertliving cistanche are used for the preparation of the medicaments for the treatment of Parkinson disease and can effectively improve the motion function of the patients with the Parkinson disease, slow the progress in the course of the Parkinson disease and bring a new hope for the treatment of the Parkinson disease by using traditional Chinese medicine.

Description

technical field [0001] The present invention relates to the application of the extract of Cistanche deserticola, in particular to the new application of the extract of Cistanche deserticola in pharmacy. Background technique [0002] Herba Cistanchis (Herba Cistanchis) is a plant of the genus Cistanchis in the family of Danaceae. It was first recorded in "Shen Nong's Materia Medica", and it is a commonly used variety in TCM tonic medicines. Cistanche Herba Cistanche Indications: impotence due to kidney deficiency, nocturnal emission and premature ejaculation, female infertility, weakness of muscles and bones due to liver and kidney deficiency, cold pain in the waist and knees after senile illness, postpartum, insufficient body fluid, intestinal dryness and constipation. At present, total glycosides of Cistanche deserticola (components of phenylethanol glycosides, also known as total glycosides of Cistanche deserticola) are extracted from Cistanche deserticola. The commercial...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K31/7032A61K9/00A61P25/16A61K135/00
Inventor 蔡定芳赵虹李文伟杨云柯唐红敏顾喜喜范越
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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