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Medicament composition and use thereof in preparing antimicrobial medicament

A composition and drug technology, applied in the directions of drug combinations, antibacterial drugs, antiviral agents, etc., can solve the problems of slow effect of herpes labialis, lack of broad-spectrum, high efficiency, low toxicity, lack of effective therapeutic drugs, etc.

Inactive Publication Date: 2008-11-12
GUANGZHOU JIECHENG BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the existing products on the market, such as acyclovir, are slow in treating herpes labialis, and often take a week to heal. Physiotherapy methods such as laser and cryotherapy are often used for flat warts, and there is a lack of effective treatment drugs.
[0011] At the same time, it can resist bacteria, fungus, virus and various skin and mucous membrane microbial infections, and also treat acne preparations, which have not been seen on the market or in the literature.
Skin and mucous membrane lesions are often of unknown etiology or mixed infection. Acne is often accompanied by skin infection or allergy, which is the cause of many skin infections or acne that cannot be cured for a long time. There is a lack of broad-spectrum, high-efficiency, low-toxicity, and effective pharmaceutical preparations for drug-resistant microorganisms in clinical practice. The development of such preparations is the research direction of anti-infective drugs

Method used

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  • Medicament composition and use thereof in preparing antimicrobial medicament
  • Medicament composition and use thereof in preparing antimicrobial medicament
  • Medicament composition and use thereof in preparing antimicrobial medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of the composition anti-HPV virus effervescent tablet of compound diammonium glycyrrhizinate, tannic acid and triclosan:

[0037] Diammonium Glycyrrhizinate 0.20g

[0038] Tannic acid 1.00 g

[0039] Triclosan 0.10g

[0040] Tartaric acid 0.45 g

[0041] Sodium bicarbonate 0.65 g

[0042] Dextrin 0.02g

[0043] PEG6000 0.01g

[0044] Preparation method: Take diammonium glycyrrhizinate, tannic acid, triclosan and tartaric acid and pass through 80-mesh sieve respectively, make soft material with 95% ethanol, pass through 12-mesh sieve to make wet granules, dry at 50°C, and set aside. Separately take sodium bicarbonate plus sterile distilled water to make soft materials, pass through a 12-mesh sieve to make wet granules, dry at 50°C, then mix with the above dry granules, granulate, add appropriate amount of sterilized distilled water, bake for a while, add PEG6000, dextrin . Mix well and compress into tablets.

Embodiment 2

[0046] Preparation of compound tripotassium glycyrrhizinate, tannic acid and triclosan disinfectant:

[0047] Tripotassium Glycyrrhizinate 0.10g

[0048] Tannic acid 5.00g

[0049] Triclosan 0.30g

[0050] 1,2-propanediol 20ml

[0051] Tween-80 20ml

[0052] Azone 3ml

[0053] Adjust pH to 5.5 with HCl or NaOH

[0054] Sterilized distilled water to 100ml

Embodiment 3

[0056] Preparation of Compound Glycyrrhizic Acid, Tannic Acid and Triclosan Disinfectant:

[0057] Glycyrrhizic acid 1.00 g

[0058] Tannic acid 5.00g

[0059] Triclosan 0.50g

[0060] 1,2-Propanediol 15ml

[0061] Tween-80 15ml

[0062] Azone 3ml

[0063] Adjust pH to 5.5 with HCl or NaOH

[0064] Sterilized distilled water to 100ml

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Abstract

The invention relates to an application of glycyrrhizic acid or a compound of a salt thereof and tannic acid and triclosan in the preparation of anti skin mucous membrane microorganism and acne drugs, in particular to the application in the preparation of drugs for preventing and treating bacteria, mycotic and virus infections of skin mucous membranes of human beings and animals, acne drugs, disinfectant and daily chemical products, wherein, the infections comprise verruca acuminate, verruca plana, common warts, colpitis, cervicitis, cervical erosion, herpes simplex, herpes zoster, herpes genitalis and aece. The application is to blend the glycyrrhizic acid or the compound of the salt thereof and the tannic acid and the riclosan with various auxiliary materials of skin mucous membrane dosage and prepare the mixture into different preparations.

Description

technical field [0001] The invention relates to the application of the composition of glycyrrhizic acid or its salt, tannic acid and triclosan in the preparation of anti-skin and mucous membrane microorganisms and acne medicine. Specifically, it relates to the application of the composition of glycyrrhizic acid or its salt, tannic acid and triclosan for the preparation of medicines, disinfectants and daily chemical products for the treatment of human and animal skin and mucous membrane bacteria, fungi, viral infections and acne. Background technique [0002] Glycyrrhizic acid or its salts have non-specific immunomodulatory effects, which mainly enhance cellular immunity, enhance phagocytosis, selectively enhance the proliferation and activity of helper T lymphocytes, and have antimicrobial, liver protection, detoxification, anti-inflammatory, Anti-allergic, anti-allergic and other biological effects. In vitro anti-Epstein-Barr virus experiment [Jung-Chung Lin. Mechanism of ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/06A61K9/02A61K9/20A61P31/04A61P31/12A61P31/00A61P17/10A61P15/02A61K31/7028A61K31/085
Inventor 蒋光愉白大成
Owner GUANGZHOU JIECHENG BIOLOGICAL TECH
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