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Emulsion type gel preparation containing chlorhexidine and alcohol
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A gel preparation and emulsion technology, which is applied in the field of emulsion-type gel preparations, can solve the problems of uneven rubbing affecting the disinfection effect, dry and cracked skin and allergies, inconvenient operation, etc. The effect of convenient clinical operation
Active Publication Date: 2011-10-26
利康医药科技江苏有限公司
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Summary
Abstract
Description
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Problems solved by technology
[0005] At present, most of the disinfection products containing chlorhexidine or ethanol commonly used in the market are solution dosage forms. Since chlorhexidine and ethanol are obviously irritating to the skin, even if a specific skin care agent is added, it still produces a very uncomfortable feeling after use. Even cause skin dryness and allergies
In the clinical hand disinfection process, the solution-type products are easy to spill when they are taken by hand, which is very inconvenient to operate, and it is easy to affect the disinfection effect due to uneven rubbing
Method used
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Examples
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Effect test
Embodiment 1
[0037] Heat 50 grams of stearic acid, 25 grams of white petrolatum, and 10 grams of lanolin to 70-80°C, and mix well to obtain liquid A; 5 grams of chlorhexidine, 10 grams of triethanolamine, 50 grams of glycerin, and xanthan gum 3 grams, 147 grams of water, heated to 70-80°C, stirred and dissolved to obtain liquid B; while stirring, slowly add liquid A to liquid B while hot, continue stirring until the temperature naturally drops to 50°C, add 700 grams of ethanol , and stirred for 1.5 hours to obtain the emulsion-type gel preparation.
Embodiment 2
[0039] Heat 80 grams of stearic acid, 20 grams of white petrolatum, and 15 grams of lanolin to 70-80 ° C, mix well, and obtain liquid A; mix 15 grams of chlorhexidine, 20 grams of triethanolamine, 30 grams of glycerin, and xanthan gum 5 grams, 215 grams of water, heated to 70-80°C, stirred and dissolved to obtain liquid B; while stirring, slowly add liquid A to liquid B while hot, continue stirring until the temperature naturally drops to 60°C, add 600 grams of ethanol , and stirred for 2 hours to obtain the emulsion-type gel preparation.
Embodiment 3
[0041] Heat 100 grams of stearic acid, 30 grams of white petrolatum, and 20 grams of lanolin to 70-80°C, and mix well to obtain liquid A; 40 grams of chlorhexidine, 5 grams of triethanolamine, 20 grams of glycerin, and xanthan gum 5 grams, 380 grams of water, heated to 70-80°C, stirred and dissolved to obtain liquid B; while stirring, slowly add liquid A to liquid B while hot, continue to stir until the temperature naturally drops to 50°C, add 400 grams of ethanol , and stirred for 1.5 hours to obtain the emulsion-type gel preparation.
[0042] The emulsion-type gel preparation prepared as in the above examples is stable in properties, has a fast evaporation speed after use, has high moisturizing properties to the skin without obvious sticky feeling, and has a good feeling of use.
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Abstract
The invention relates to an emulsion type gel preparation containing chlorhexidine and ethanol. The emulsion type gel preparation containing chlorhexidine and ethanol comprises the following components by weight percentage: 0.5 to 5 of the chlorhexidine; 30 to 70 of the ethanol; 3 to 10 of stearic acid; 2 to 5 of white petrolatum; 0.5 to 3 of lanoline; 0.5 to 2 of triethanolamine; 1 to 5 of glycerin; 0.1 to 1 of xanthan gum; allowance of water. The stearic acid, the white petrolatum and the lanoline are heated to 70 DEG C to 80 DEG C and mixed evenly, thus obtaining solution A; the chlorhexidine, the triethanolamine, the glycerin, the xanthan gum and the water are heated to 70 DEG C to 80 DEG C, stirred and dissolved, thus obtaining solution B; when stirring, the solution A is added to the solution B slowly when the solution is hot, stirred continuously until the temperature is reduced to 50 DEG C to 60 DEG C naturally; the ethanol is added and stirred for 1 hour to 2 hours, thus obtaining the emulsion type gel preparation. The emulsion type gel preparation has stable property, fast evaporation speed after being used, high moisture retention and no obvious viscosity to skin and good use feeling.
Description
technical field [0001] The present invention relates to an emulsion type gel preparation containing chlorhexidine and ethanol, which contains chlorhexidine and ethanol with disinfection effect, has stable properties, fast volatilization speed after use, and has high moisture retention to skin There is no obvious sticky feeling, and the feeling of use is good. Background technique [0002] Hand disinfection has always been an important part of hospital infection control management. If medical staff do not wash or disinfect their hands adequately after nursing activities, it is easy to cause the germs on their hands to spread to the next patient. In order to improve the effect of hand disinfection, some hand disinfectants with good disinfection effect, rapid action, convenient use, and harmless and non-irritating to the skin are needed clinically. Chlorhexidine and ethanol are widely used in skin disinfection, hygienic hand disinfection and surgical hand disinfection in curr...
Claims
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Application Information
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