Protein conjugate and pharmaceutical compositions thereof

Abstract

The invention discloses a novel protein conjugate which is the conjugate of proteins and endogenous substances modified by cystine or cysteine. Besides, the invention also discloses a drug combination comprising the protein conjugate and the preparation method of the protein conjugate and the drug combination comprising the protein conjugate. The invention does not relate to toxic organic solvents and catalysts, reactions are simple and easy, and products are easy for separation, refinement and quality control, and moreover, the active targeting property of the obtained drug combination is improved.

Description

Technical field

[0001] The present invention relates to pharmaceutical preparation technology, and more specifically, to a novel protein conjugate, a preparation method thereof, and a pharmaceutical composition containing the protein conjugate. Background technique

[0002] In drug research, it is found that nearly 40% of drugs are poorly soluble in water, and some drugs are even insoluble in organic solvents, resulting in low bioavailability. In the preparation process, the use of cyclodextrin inclusion technology, surfactant solubilization, emulsion, microemulsion and solid dispersion technology can solve the problem of low bioavailability of some insoluble drugs, but there are still a large number of drugs due to bioavailability. Due to the degree of problems, it was abandoned. And nanosuspension technology provides these drugs with an opportunity to reproduce their own value. Nano suspension is a submicron colloidal dispersion system formed by using a small amount of surfacta...