The invention belongs to the technical field of petrochemical engineering, relates to a method for preparing epoxide in a homogeneous system with low propylene using amount, and more specifically, relates to a method for synthesizing propylene epoxide by using a first protonic solvent and a second non-protonic solvent as a mixed solvent. An active center is formed by the first protonic solvent, acatalyst and hydrogen peroxide; the second non-protonic solvent can be miscible with the first protonic solvent, and the solubility of propylene inside the mixed solvent is added; the reaction is carried out under the condition of homogeneous phase; propylene can be in contact with hydrogen peroxide sufficiently, the utilization rate of propylene and hydrogen peroxide is improved, and the using amount of propylene and the decomposition rate of hydrogen peroxide are reduced. Simultaneously, the second non-protonic solvent has good solubility for an ether compound formed in the process of an epoxidation reaction, the catalyst deactivation caused by the blockage of a catalyst pore passage can be reduced, and the stable operation time of the catalyst is prolonged effectively. Moreover, the second non-protonic solvent is introduced, the proportion of the first protonic solvent in the system is reduced, the ether byproduct generated in further reaction of propylene epoxide and the first protonic solvent can be reduced, and the yield and selectivity of propylene epoxide are improved. The method has the characteristics of simple process route, low propylene using amount, high propylene epoxide yield and selectivity and the like, and the catalyst is unlikely to inactivate.