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Oral sticking tablets using fluticasone propionate as active component

A technology of active ingredients and adhesive tablets, which is applied in the field of oral adhesive tablets with fluticasone propionate as the active ingredient, to achieve the effect of overcoming potential harm

Active Publication Date: 2013-03-20
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far neither fluticasone propionate has been used to make preparations suitable for oral mucosal topical administration, nor has there been any report on the use of fluticasone propionate preparations to treat oral ulcers

Method used

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  • Oral sticking tablets using fluticasone propionate as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] paste sheet

[0025] Fluticasone Propionate 0.1g

[0026] Carbomer 10g

[0027] Dextrin 30g

[0028] Magnesium stearate 0.03g

[0029] The protective layer

[0030] L100-55 4g

[0031] Titanium dioxide 1g

[0032] Yellow Iron Oxide 1g

[0033] Acetyl tributyl citrate (ATBC) 0.8g

[0034] Preparation Process:

[0035] Dissolve fluticasone propionate in 5ml of absolute ethanol, add the solution of the above active ingredient into the dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, and granulate through a 40-mesh sieve , add carbopol and magnesium stearate passed through a 100-mesh sieve and mix well, then press with a flat punch with a diameter of 6 mm to obtain 1000 tablets, each containing 0.10 mg of fluticasone propionate. the prescribed amount 100-55 is dissolved in 95ml of 95% ethanol, and the prescribed amount of ATBC, titanium dioxide, and yellow iron oxide is added, and each tablet weighs about 5...

Embodiment 2

[0037] For the formula of Example 1, the active ingredient is changed to fluticasone propionate 0.2g, the plasticizer is changed to tributyl citrate (TBC) and other preparation processes are the same as in Example 1

Embodiment 3

[0039] paste sheet

[0040] Fluticasone Propionate 0.3g

[0041] Carbomer 5g

[0042] Polyvinylpyrrolidone (PVP) 3g

[0043] Dextrin 30g

[0044] Magnesium stearate 0.05g

[0045] The protective layer

[0046] L100-55 4g

[0047] Titanium dioxide 0.5g

[0048] Trihexyl citrate (THC) 0.8g

[0049] Preparation Process:

[0050] Dissolve fluticasone propionate with an appropriate amount of absolute ethanol, add the solution of the above active ingredients to the dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, and granulate through a 40-mesh sieve , add carbomer, PVP, and magnesium stearate that have passed through a 100-mesh sieve, and mix well, then press a flat punch with a diameter of 6 mm to obtain 1,000 tablets, containing 0.5 mg of methylprednisolone. Dissolve L100-55 with 95ml of 95% ethanol, add the prescribed amount of THC and titanium dioxide, grind evenly, spray evenly on the surface of the tablet with...

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PUM

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Abstract

The invention discloses an oral sticking tablet used for treating canker sore of humans or mammals. The oral sticking tablet comprises a sticking layer containing an active ingredient and a water insoluble protective layer, wherein, a non-active ingredient contained in the sticking layer consists of a filling agent, an adhesive sustained-release agent and a lubricant which are applicable to tablets; the water insoluble protective layer is composed of polyacrylic acid resin and / or ethyl cellulose which can be used as protective coating, and a plasticizer; in addition, the active ingredient is fluticasone propionate.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating oral ulcers in humans or mammals and its application, in particular to an oral adhesive tablet Background technique: [0002] Oral ulcer is also called recurrent aphtha, is commonly called as aphthous ulcer, is a kind of common oral cavity membrane disease. Recurrent oral ulcers refer specifically to a class of unexplained, recurrent but self-limited, isolated, round or oval ulcers. It is also called recurrent aphthous ulcer (Aphthous is the meaning of "burning and ulceration" in Greek) or recurrent aphthous ulcer. Clinically, it can be divided into three types according to the size, depth and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal periadenitis. [0003] Recurrent oral ulcers are one of the most common diseases in oral mucosal diseases. In people's life, there are almost no oral ulcers that do not occur, but some pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/56A61P1/02
Inventor 李静张其婉李宏铃马晓勇韩英陈松
Owner TIANJIN PHARMA GROUP CORP