Percutaneous absorption patch

A technology of patches and preparations, applied in the direction of anti-inflammatory agents, nervous system diseases, non-central analgesics, etc., to achieve long-lasting analgesic effect

Inactive Publication Date: 2009-02-25
COSMED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although, the adhesive used in the above-mentioned patch type preparation does not have free carboxyl groups, and free hydroxyl groups only account for 5.2% by mass percentage. It is a neutral adhesive with excellent adhesion and can be attached to the skin well. A matrix type patch that allows fentanyl to be administered transdermally in an appropriate amount for a long time has not yet been obtained.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、 comparative example 1～9

[0027] According to the proportion shown in Table 1, add fentanyl, polyethylene glycol monocetyl ether, n-caprylic acid, lauric acid diethanolamine and polyvinylpyrrolidone (Nacalai tesque, Japan, trade name Diethanolamine laurate K-90, average molecular weight 360,000), uniformly mixed to form a transdermal absorption preparation solution, coated on a polyethylene terephthalate (PET) film, controlling the thickness of the coating, and making the film dry The thickness is 200 μm, dried at 50° C. for 24 hours, and the transdermal absorption patch is prepared after the solvent evaporates.

[0028] Table 1

[0029]

Embodiment 2

[0031] Fentanyl was replaced with fentanyl citrate, and the others were the same as in Example 1 to prepare a percutaneous absorption patch.

Embodiment 3

[0033] Except that fentanyl citrate was used to replace fentanyl, 2.42 weight ratio of sodium hydroxide was added, and the others were the same as in Example 1 to obtain a percutaneous absorption patch.

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Abstract

The invention provides a percutaneous absorptive patch, wherein percutaneous absorptive preparation layer composed of copolymer of acrylic acid 2-ethylhexyl of 70 to 80 wt.% and vinyl pyrrolidone of 30 to 20 wt.%, polyethylene glycol mono-hexadecyl ether, n-octanoic acid and / or oleic acid, dodecylic acid diethanol amine, plasmosan and fentanyl, is present on a surface of a backing layer that has no permeability to drugs, in the percutaneous absorptive preparation layer, the weight ratio of copolymer of acrylic acid 2-ethylhexyl of 70 to 80 wt.% and vinyl pyrrolidone of 30 to 20 wt.%, polyethylene glycol mono-hexadecyl ether, n-octanoic acid and / or oleic acid, dodecylic acid diethanol amine, plasmosan and fentanyl (citrate) is 100:1-10:1-10:1-5: 5-20:5-15.

Description

technical field [0001] The present invention relates to a matrix type percutaneous absorption patch containing fentanyl (citrate). Background technique [0002] Fentanyl is a high-efficiency analgesic that can achieve its efficacy in a small dose, so it can be used as a percutaneous absorption preparation. For example, a reservoir-type percutaneous absorption preparation in which fentanyl is filled in liquid or colloidal form between a backing layer and a release-controlling membrane is already on the market. [0003] However, in the above-mentioned reservoir-type percutaneous absorption preparation, once the drug reservoir leaks, the contents of the reservoir containing fentanyl will come into contact with the skin over a large area, resulting in excessive absorption of fentanyl. Excessive absorption of fentanyl will quickly lead to respiratory depression, there is a fatal danger. [0004] In order to overcome this fatal defect, there are also people who carry out researc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4468A61P25/04
CPCA61K31/4468A61K9/7061A61K9/7053A61P25/04A61P29/00
Inventor 神山文男权英淑
Owner COSMED PHARMA
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