Lidocaine hydrochloride mucilage preparation method

Abstract

A method for preparing a lidocaine hydrochloride mucilage comprises the following steps: a formula amount of ethyl p-hydroxybenzoate is put into purified water which accounts for 25% of the total volume of the ethyl p-hydroxybenzoate, heated and stirred until complete dissolution, added with a formula amount of lidocaine hydrochloride and stirred for dissolution, added with a formula amount of glycerol and stirred evenly; additionally, a formula amount of sodium carboxymethyl cellulose is added to purified water which accounts for 50% of the total volume of the sodium carboxymethyl cellulose, and stirred for complete swelling; the two solutions obtained are mixed evenly, and added with 0.1N sodium hydroxide to adjust the pH value to 6.0-7.0; the monarch drug content of the obtained mucilage is determined; the mucilage is added with water to sufficient amount, mixed evenly and filled, and sterilized by 110 DEG C saturated vapor for 30 minutes; inspected under a lamp and packaged to obtain the finished product. Compared with the prior art, the lidocaine hydrochloride mucilage has the advantages of matching anaesthesia and inspection time, good lubricating property and sterility assurance level.

Description

【Technical field】 [0001] The invention belongs to a preparation method of lidocaine hydrochloride mucilage used before gastroscopy. 【Background technique】 [0002] Gastroscopy is one of the most commonly used methods for diagnosis and treatment of upper gastrointestinal diseases, and it has an intuitive effect that cannot be replaced by other diagnosis and treatment methods. However, during the gastroscopy examination, the patient suffers from nausea, vomiting, coughing and other symptoms due to irritation of the throat, and many patients refuse the examination due to fear and fear. To eliminate the adverse symptoms produced by gastroscopy, the current commonly used method is to take local anesthetics orally. Lidocaine hydrochloride oral preparation is one of oral local anesthetics. It has the advantages of fast absorption, good local anesthesia effect, strong mucosal penetration, no local stimulation and vasodilation effect, etc. It is currently the most widely used local ...

AI Technical Summary

Problems solved by technology

But existing lidocaine hydrochloride oral preparation has following problems in practical application: 1, the contact time of medicinal liquid in throat and mucous membrane is shorter, influences drug effect to some extent

2. The lubricating performance is not good, and it is easy to irritate the mucous membrane of the throat when the lens is inserted, causing adverse reactions such as coughing, nausea, and vomiting in the patient, and it is difficult to completely eliminate the pain of the patient

3. The degree of sterility is low, and there is a phenomenon of bacterial infection