Lidocaine hydrochloride mucilage preparation method

A technology of lidocaine hydrochloride and mucilage, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of difficult to completely eliminate the pain of patients, easily irritated throat mucous membrane, poor lubricating performance, etc. Problems, to achieve good anesthesia and lubrication, prevent drug absorption too fast, fast onset effect

Inactive Publication Date: 2009-03-18
浙江康德药业集团股份有限公司
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But existing lidocaine hydrochloride oral preparation has following problems in practical application: 1, the contact time of medicinal liquid in throat and mucous membrane is shorter, influences drug effect to some extent
2. The lubricating performance is not good, and it is easy to irritate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 6 grams of ethyl p-hydroxybenzoate and put it in 2500ml purified water, heat and stir to dissolve completely, add 200 grams of lidocaine hydrochloride, stir to dissolve, add 1200 grams of glycerin, stir evenly; take another 80 grams of carmellose sodium In 5000ml of purified water, stir to make it completely swell, mix the above two liquids evenly, adjust the pH value to 6.0 with 0.1N sodium hydroxide, measure the main drug content of the glue, add water to 10000g, mix evenly, fill in Sterilize under saturated steam conditions at 110°C for 30 minutes, inspect with lights, and package to complete the product.

Embodiment 2

[0015] Put 6 grams of ethyl p-hydroxybenzoate in 2500ml purified water, heat and stir to dissolve completely, add 200 grams of lidocaine hydrochloride, stir to dissolve, add 800 grams of glycerin, and stir well; In 5000ml of purified water, stir to swell completely, mix the above two liquids evenly, adjust the pH value to 7.0 with 0.1N sodium hydroxide, measure the main drug content of the glue, add water to 10000g, mix evenly, fill in Sterilize under saturated steam conditions at 110°C for 30 minutes, inspect with lights, and package to complete the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A method for preparing a lidocaine hydrochloride mucilage comprises the following steps: a formula amount of ethyl p-hydroxybenzoate is put into purified water which accounts for 25% of the total volume of the ethyl p-hydroxybenzoate, heated and stirred until complete dissolution, added with a formula amount of lidocaine hydrochloride and stirred for dissolution, added with a formula amount of glycerol and stirred evenly; additionally, a formula amount of sodium carboxymethyl cellulose is added to purified water which accounts for 50% of the total volume of the sodium carboxymethyl cellulose, and stirred for complete swelling; the two solutions obtained are mixed evenly, and added with 0.1N sodium hydroxide to adjust the pH value to 6.0-7.0; the monarch drug content of the obtained mucilage is determined; the mucilage is added with water to sufficient amount, mixed evenly and filled, and sterilized by 110 DEG C saturated vapor for 30 minutes; inspected under a lamp and packaged to obtain the finished product. Compared with the prior art, the lidocaine hydrochloride mucilage has the advantages of matching anaesthesia and inspection time, good lubricating property and sterility assurance level.

Description

【Technical field】 [0001] The invention belongs to a preparation method of lidocaine hydrochloride mucilage used before gastroscopy. 【Background technique】 [0002] Gastroscopy is one of the most commonly used methods for diagnosis and treatment of upper gastrointestinal diseases, and it has an intuitive effect that cannot be replaced by other diagnosis and treatment methods. However, during the gastroscopy examination, the patient suffers from nausea, vomiting, coughing and other symptoms due to irritation of the throat, and many patients refuse the examination due to fear and fear. To eliminate the adverse symptoms produced by gastroscopy, the current commonly used method is to take local anesthetics orally. Lidocaine hydrochloride oral preparation is one of oral local anesthetics. It has the advantages of fast absorption, good local anesthesia effect, strong mucosal penetration, no local stimulation and vasodilation effect, etc. It is currently the most widely used local ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/06A61K31/167A61P23/02
Inventor 冯荣权邵良碧何郑红
Owner 浙江康德药业集团股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap