Uniconazole-cyclodextrin clathrate, preparation method and use thereof
A technology of cyclodextrin inclusion complex and uniconazole, which is applied in the agricultural field, can solve the problems of easy photolysis and optical isomerism, poor water solubility, low biological utilization efficiency, etc., achieves high safety and biological activity, and reduces organic solvents. use and improve bioavailability
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Embodiment 1
[0033] Embodiment 1: the preparation of uniconazole-cyclodextrin
[0034] Weigh 11.35 grams of β-cyclodextrin and put it in a mortar, add 5ml of water to grind evenly, then add 0.292 grams of uniconazole dissolved in 2ml of acetone (the molar ratio of uniconazole to cyclodextrin is 0.1:1), Continue to grind until a white emulsion is formed. After the emulsion is mixed with 10 ml of water, centrifuge at 4000 rpm for 10 minutes, take the supernatant, wash the precipitate with 10 ml of water, and take the supernatant after centrifugation again. The liquids were combined, placed overnight at 4°C, freeze-dried to constant weight, and the white powder obtained was the clathrate of the present invention. The yield of the clathrate was 62.4%, and the content of the active ingredient uniconazole was 1.8%.
Embodiment 2
[0035] Embodiment 2: the preparation of uniconazole-cyclodextrin
[0036] Weigh 5.700 grams of β-cyclodextrin and place it in a mortar, add 2.5ml of water to grind evenly, then add 0.292 grams of uniconazole dissolved in 1.5ml of ethanol (the molar ratio of uniconazole to cyclodextrin is 0.25:1 ), continue to grind until a white emulsion is formed, mix the emulsion with 10 ml of water, centrifuge at 4000 rpm for 10 minutes, take the supernatant, wash the precipitate with 10 ml of water, centrifuge again, take the supernatant, and separate twice The supernatants were combined, placed overnight at 4°C, and freeze-dried to constant weight to obtain a white powder, which was the clathrate of the present invention. The yield of the clathrate was 79.3%, and the content of the active ingredient uniconazole was 11.6%.
Embodiment 3
[0037] Embodiment 3: the preparation of uniconazole-cyclodextrin
[0038] Weigh 3.800 g of β-cyclodextrin, dissolve it in 200 ml of distilled water, stir to prepare saturated solution A, then weigh 0.978 g of uniconazole, (the molar ratio of uniconazole to cyclodextrin is 1:1) dissolve In acetone, prepare a saturated solution B. Under stirring at room temperature at 800 rpm, solution B was slowly dropped into solution A, and stirring was continued for 4 hours. After the end, the obtained suspension is suction-filtered, the filter cake is washed with absolute ethanol and water successively, and the white powder obtained by vacuum drying is the clathrate of the present invention. The yield of the clathrate is 63.2%, and the content of the active ingredient uniconazole is 12.5%.
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