Uniconazole-cyclodextrin clathrate, preparation method and use thereof

A technology of cyclodextrin inclusion complex and uniconazole, which is applied in the agricultural field, can solve the problems of easy photolysis and optical isomerism, poor water solubility, low biological utilization efficiency, etc., achieves high safety and biological activity, and reduces organic solvents. use and improve bioavailability

A technology of cyclodextrin inclusion complex and uniconazole, which is applied in the agricultural field, can solve the problems of easy photolysis and optical isomerism, poor water solubility, low biological utilization efficiency, etc., achieves high safety and biological activity, and reduces organic solvents. use and improve bioavailability

CN101390513BActive Publication Date: 2011-10-05CHINA AGRI UNIV
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  • Uniconazole-cyclodextrin clathrate, preparation method and use thereof
  • Uniconazole-cyclodextrin clathrate, preparation method and use thereof
  • Uniconazole-cyclodextrin clathrate, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the preparation of uniconazole-cyclodextrin

[0034] Weigh 11.35 grams of β-cyclodextrin and put it in a mortar, add 5ml of water to grind evenly, then add 0.292 grams of uniconazole dissolved in 2ml of acetone (the molar ratio of uniconazole to cyclodextrin is 0.1:1), Continue to grind until a white emulsion is formed. After the emulsion is mixed with 10 ml of water, centrifuge at 4000 rpm for 10 minutes, take the supernatant, wash the precipitate with 10 ml of water, and take the supernatant after centrifugation again. The liquids were combined, placed overnight at 4°C, freeze-dried to constant weight, and the white powder obtained was the clathrate of the present invention. The yield of the clathrate was 62.4%, and the content of the active ingredient uniconazole was 1.8%.

Embodiment 2

[0035] Embodiment 2: the preparation of uniconazole-cyclodextrin

[0036] Weigh 5.700 grams of β-cyclodextrin and place it in a mortar, add 2.5ml of water to grind evenly, then add 0.292 grams of uniconazole dissolved in 1.5ml of ethanol (the molar ratio of uniconazole to cyclodextrin is 0.25:1 ), continue to grind until a white emulsion is formed, mix the emulsion with 10 ml of water, centrifuge at 4000 rpm for 10 minutes, take the supernatant, wash the precipitate with 10 ml of water, centrifuge again, take the supernatant, and separate twice The supernatants were combined, placed overnight at 4°C, and freeze-dried to constant weight to obtain a white powder, which was the clathrate of the present invention. The yield of the clathrate was 79.3%, and the content of the active ingredient uniconazole was 11.6%.

Embodiment 3

[0037] Embodiment 3: the preparation of uniconazole-cyclodextrin

[0038] Weigh 3.800 g of β-cyclodextrin, dissolve it in 200 ml of distilled water, stir to prepare saturated solution A, then weigh 0.978 g of uniconazole, (the molar ratio of uniconazole to cyclodextrin is 1:1) dissolve In acetone, prepare a saturated solution B. Under stirring at room temperature at 800 rpm, solution B was slowly dropped into solution A, and stirring was continued for 4 hours. After the end, the obtained suspension is suction-filtered, the filter cake is washed with absolute ethanol and water successively, and the white powder obtained by vacuum drying is the clathrate of the present invention. The yield of the clathrate is 63.2%, and the content of the active ingredient uniconazole is 12.5%.

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Abstract

The invention provides a plant growth regulator, wherein, uniconazole is dissolved in an appropriate amount of organic solvent to have inclusion reaction with cyclodextrin or the derivatives thereof, and then dried to obtain the regulator. The solubility, sustained-release performance and bioavailability of the uniconazole-cyclodextrin inclusion compound are greatly improved, so that the plant growth regulator can effectively regulate wheat, soybean, corn, rice and other crops, control node elongation and prevent over-luxuriant growth and lodging.

Description

technical field [0001] The invention belongs to the technical field of agriculture, and relates to a cyclodextrin inclusion compound of a plant growth regulator, and also relates to a preparation method and application of the cyclodextrin inclusion compound. Background technique [0002] The application of plant growth regulators is an important new technology to improve crop productivity (Wei Fuxiang, Anhui Agriculture, 1999, 3, 11). With the increasingly prominent environmental problems, chemical pesticides are facing enormous pressure in the fields of production, sales and application, and the International Food and Agriculture Organization (FAO) and other countries in the world have also continuously increased the restrictions on pesticide residues. The loss rate of traditional preparations due to volatilization, photolysis, hydrolysis or leaching loss can reach 50%-60%. At the same time, a large amount of organic solvents are often used in the processing process, which ...

Claims

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Application Information

Patent Timeline
05 Oct 2011
Publication
CN101390513B
IPC
A01N25/30; A01N43/653; A01P21/00
Inventors
段留生; 李召虎