Method for producing lactic acid ester with ion liquid catalysis

An ionic liquid, catalytic preparation technology, applied in chemical instruments and methods, preparation of organic compounds, preparation of carboxylic acid esters, etc., can solve problems such as environmental pollution, achieve low price, good selectivity, easy control and industrial production. Effect

Inactive Publication Date: 2009-04-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because the anion contains F in the ionic liquid, it is easy to decompose and generate HF when it meets water, which will pollute the environment.

Method used

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  • Method for producing lactic acid ester with ion liquid catalysis
  • Method for producing lactic acid ester with ion liquid catalysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Put 0.05mol ionic liquid 1-methylimidazolium bisulfate, 0.2mol methanol, 0.1mol racemic lactic acid, 0.1mol ethyl acetate into a round-bottomed flask equipped with a reflux condenser, stir magnetically, and heat at 63°C Heating and reacting for 2 hours; then atmospheric pressure distillation to remove alcohol and ethyl acetate, and then vacuum distillation to collect the product racemic methyl lactate with a yield of 90% and a selectivity of 100%; the ionic liquid was subjected to vacuum dehydration treatment and reused.

Embodiment 2

[0027] Put 0.04mol ionic liquid 1-methylimidazolium bisulfate, 0.15mol ethanol, 0.1mol racemic lactic acid, 0.1mol ethyl acetate into a round-bottomed flask equipped with a reflux condenser, stir magnetically, and heat at 70°C Heating and reacting for 3 hours; then removing alcohol and ethyl acetate by distillation under normal pressure, and then collecting the product racemic ethyl lactate by distillation under reduced pressure, with a yield of 88% and a selectivity of 100%; the ionic liquid is reused after vacuum dehydration.

Embodiment 3

[0029] With 0.06mol ionic liquid 1-methylimidazolium bisulfate, 0.18mol n-propanol, 0.1mol racemic lactic acid, 0.1mol ethyl acetate; add in the round bottom flask equipped with reflux condenser, magnetically stir, and in Heating and reacting at 82°C for 6 hours; then distilling off alcohol and ethyl acetate under normal pressure, and then distilling under reduced pressure to collect the product racemic n-propyl lactate, with a yield of 77% and a selectivity of 97%; the ionic liquid is reused after vacuum dehydration .

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Abstract

The invention discloses a method for making lactate by ionic liquid catalyst. The method comprises the following steps: mixing alcohol and acid the molar ratio of which is 1.5 to 2 with a Brphinsted acid imidazole ionic liquid as a catalyst and a solvent for reaction together, adding ethyl acetate as a dehydrating agent, stirring and reacting for 2 to 6 hours under normal pressure at a temperature of between 60 and 90 DEG C, then distilling under the normal pressure to remove alcohol and ethyl acetate, and finally reducing pressure and stilling to collect products, wherein the feeding amount of the ionic liquid is 10 to 50 percent of the total mol number of the alcohol and acid. Because the ionic liquid catalyst used in the method has high catalytic activity, good selectivity, low cost and stable quality, is not easy to hydrate, and can be used repeatedly through simple vacuum dehydration, the method has high percent conversion and can reduce the cost for manufacturing the lactate greatly.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of lactic acid esters, in particular to a method for catalyzing the preparation of lactic acid esters with ionic liquids. Background technique [0002] Lactate (methyl lactate, ethyl lactate, n-propyl lactate, isopropyl lactate, etc.) is a non-toxic, soluble and easy-to-recycle organic solvent, so it is widely used in spices, synthetic resin coatings, adhesives, printing In the production of ink, etc., it is also used for oil pipeline cleaning and electronic industry cleaning. People often use it as a solvent for nitrocellulose, cellulose acetate and artificial pearls; Ester is also used in the synthesis of spices and herbicides, so it is a biodegradable "green solvent" with great development value and application prospects, and has a very wide range of uses in industry. The traditional lactic acid ester synthesis process uses alkyd as a reactant and concentrated sulfuric acid as a c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/68C07C67/08B01J31/02
CPCY02P20/54
Inventor 宋航张义文杜开峰王欣雷强
Owner SICHUAN UNIV
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