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Immunoenhancement regulator of pig blue-ear disease vaccine and use thereof

A technology for immune enhancement and porcine PRRS, which is applied in the field of animal health care and bioimmune medicine, can solve the problems that are not specially used to improve the immune effect of PRRS vaccine, so as to improve the level of plasma antibodies, solve the problem of low antibody levels, The effect of enhancing the phagocytosis of macrophages

Active Publication Date: 2009-05-06
CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the method of improving the antibody level of vaccines, especially PRRS, is mostly to improve the immune adjuvant, which has not been specifically used to improve the immune effect of PRRS vaccines, promote the generation of neutralizing antibody levels in advance, and improve pig cell immunity against PRRS The function is particularly the immunoenhancement of macrophage function and the functional feed thereof, the present invention just provides a kind of immunity enhancement and the adjustment agent of pig PRRS vaccine and its functional feed, and in pig PRRS vaccine and the application in health care prevention and control of highly pathogenic PRRS

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prevention and control methods of sow PRRS and highly pathogenic PRRS

[0037] After mixing the immunoenhancing and regulating agent of the present invention added in a proportion of 0.75% in the full-price feed previously fed, it was first fed for 5 days, then injected with PRRS commercial vaccine, and continued to be fed for 15 days. This method increases the antibody level in the sow serum by more than 30%, because the maternal antibody in the colostrum is positively correlated with the plasma level, therefore, the corresponding antibody level in the colostrum is also increased by more than 30%.

[0038] The feed can be prepared according to the following formula: 65% corn, 9.5-10.5% wheat bran, 20% soybean meal, 0.5-1.5% immune enhancement regulator of the present invention, 4% sow premix (produced by Changsha Shuren Animal Husbandry Technology Co., Ltd. ).

Embodiment 2

[0040] Prevention and control methods of PRRS and highly pathogenic PRRS in suckling piglets

[0041] The one is to apply the method of Example 1 to improve the antibody level in the sow serum by more than 30%; the second is to raise the sow in the late pregnancy, promote the development of fetal immune organs, and increase the birth weight by more than 30%; the third is to raise the lactating sow and improve the sow Pig milk production 30%, increase the quality and quantity of colostrum. Use of maternal antibodies to protect lactating piglets. The combination of the above three methods can prolong the protection time of maternal antibody by more than 50%, reaching 35-38 days.

Embodiment 3

[0043] Prevention and control methods of PRRS and highly pathogenic PRRS in weaned nursery piglets

[0044] The protection method for weaned nursery piglets of the present invention is based on the prevention and control method for suckling piglets, and the immune enhancement and regulator of the present invention can be added to the original full-price feed by 0.75-1.5% and mixed evenly, and the piglets are 16 days old. Start feeding, and then, 21-25 days old, inject commercial inactivated vaccine against PRRS, and continue feeding for 10-25 days. The above method can advance the generation time of neutralizing antibodies by 3-8 days. Therefore, the window period of infection before the age of 43 days in piglets is basically eliminated, and the probability of infection in piglets is greatly reduced.

[0045] The feed can be prepared according to the following formula: 63.5-64.25% of corn, 15% of soybean meal, 0.75-1.5% of the immune enhancement regulator of the present invent...

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Abstract

The invention discloses an immunoenhancement modifying agent of a vaccine for pig blue-ear disease, and the percent concentration thereof is as follows: epimedium extract: 5 to 10 percent, oligoisomaltose: 2 to 5 percent, vitamin C: 0.5 to 1 percent, vitamin E: 0.2 to 0.5 percent, and carrier (such as bran): 83.5 to 92 percent. The invention also can be realized by preparing immunoenhancement and regulatory function complete feed or concentrate feed and premix compound. The modifying agent can obviously raise the antibody level of the pigs being injected with the vaccine for blue-ear disease, bring forward the generation time of neutralizing antibody level and greatly increase the phagocytic function of organism macrophages. The method is convenient for preparation and use and suitable for mass production without increasing cultivation cost.

Description

technical field [0001] The invention belongs to the fields of animal health care and bioimmune medicine, and relates to an immune enhancement modulator of porcine blue ear disease vaccine, functional feed and application thereof. Background technique [0002] Beginning in the summer and autumn of 2006, "high fever" with porcine reproductive and respiratory syndrome (PRRSV or blue ear disease) as the main culprit broke out in some parts of China. The disease spreads quickly and is an acute and highly fatal disease caused by a mutated highly pathogenic porcine reproductive and respiratory syndrome virus. Clinically, pregnant sows have a large number of abortions, stillbirths, premature births, and weak offspring. The abortion rate of pregnant sows can reach 30%, and in severe cases it can reach 70%, or even 80%. Lactating sows are severely short of milk, or even have no milk; The mortality rate of pigs decreases with the increase of age, and the mortality rate is 80%-100% wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61K47/02A61K47/44A61P37/02A61P31/14A23K1/16A61K31/355A61K31/375A61K31/702A61K47/46
Inventor 文利新邬静伍小松王国强曾五芽
Owner CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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