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Method for extracting radix gynurae segeti alkaloid with supercritical carbonic anhydride

A carbon dioxide and supercritical technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of time-consuming, low purity and extraction rate, complicated process, etc., to achieve increased yield, strong selectivity, and high extraction rate Effect

Inactive Publication Date: 2009-05-13
JIUJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the extraction of chrysanthemum notoginseng is mainly the organic solvent extraction method. The organic solvent extraction method is not only complicated in procedure, labor-intensive, time-consuming, and pollutes the environment, but also has low purity and extraction rate, which cannot solve the problems of organic residues and heavy metals in the product, and does not Meet the current technical requirements for the development of traditional Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 100g of 20 mesh medicinal powder that has been alkalized and dried with 2% ammonia water and put it into the extraction kettle in the supercritical device. Before extraction, the carbon dioxide is first refrigerated and liquefied, and then pumped into the extraction kettle by a high-pressure pump. Make the pressure reach the preset value 15MPa, and the temperature is controlled at 40 0 C, then open the extraction circulation loop "extraction kettle-separator-separator 2-extraction kettle" to extract, adjust CO 2 The opening degree of the inlet valve into the separator is to control the pressure of the separator at 6MPa and the temperature at 35 0 C, the pressure of the separator is controlled at 5MPa, while the temperature is controlled at 35 0 C. Add 100ml of 95% ethanol as an entrainer. The entrainer ethanol is added with a high-pressure pump. After the extraction is carried out for 1 hour, stop the extraction, open the exhaust valve to relieve the pressure, and obt...

Embodiment 2

[0021] Weigh 100g of 80 mesh medicinal powder after alkalization and drying with 2% ammonia water and put it into the extraction kettle in the supercritical device. Before extraction, the carbon dioxide is first refrigerated and liquefied, and then pumped into the extraction kettle by a high pressure pump. Make the pressure reach the preset value 35MPa, and the temperature is controlled at 65 0 C, then open the extraction circulation loop "extraction kettle-separator 1-separator 2-extraction kettle" for extraction and adjust CO 2 The opening degree of the inlet valve into the separator is to control the pressure of separator 1 at 6MPa and the temperature at 35 0 C, the pressure of separator 2 is controlled at 5MPa, while the temperature is controlled at 35 0 C. Add 100ml of 95% ethanol as an entrainer. The entrainer ethanol is added with a high-pressure pump. After 3 hours of such extraction, stop the extraction, open the exhaust valve to relieve the pressure, and obtain a crude e...

Embodiment 3

[0023] Weigh 100g of 60-mesh medicinal powder that has been alkalized and dried with 2% ammonia and put it into the extraction kettle in the supercritical device. Before extraction, the carbon dioxide is first refrigerated and liquefied, and then pumped into the extraction kettle by a high-pressure pump. Make the pressure reach the preset value 20MPa, and the temperature is controlled at 55 0 C, then open the extraction circulation loop "extraction kettle-separator 1-separator 2-extraction kettle" for extraction and adjust CO 2 The opening degree of the inlet valve into the separator is to control the pressure of separator 1 at 6MPa and the temperature at 35 0 C, the pressure of separator 2 is controlled at 5MPa, while the temperature is controlled at 35 0 C. Add 100ml of 95% ethanol as an entrainer. The entrainer ethanol is added with a high-pressure pump. After 2 hours of such extraction, stop the extraction, open the exhaust valve to relieve the pressure, and obtain a crude ext...

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Abstract

The invention relates to a method for extracting an alkaloid from traditional Chinese medicine radix gynurae segeti by using supercritical carbon dioxide. The method comprises the following steps: the food grade CO2 is adopted to be transformed into supercritical CO2 by pressurization; the crushed radix gynurae segeti medicinal herb is thrown into an extraction kettle to obtain a crude extract by selecting the process parameters of temperature, pressure, time and the like, and the total alkaloid in the traditional Chinese medicine radix gynurae segeti is obtained from the crude extract by post-treatment. The invention has the advantages of simple and economic process flow and high operability, and can be used for industrial production, and the obtained total alkaloids in the radix gynurae segeti can be used for traditional Chinese medicine preparation.

Description

Technical field [0001] The invention uses supercritical carbon dioxide to extract the alkaloids of Panax notoginseng, belongs to the development of Chinese medicine, and is dedicated to the extraction of alkaloids from Panax notoginseng. technical background [0002] Chrysanthemum notoginseng is a plant of the genus Gynura segetu'm (Lout.) Merr. of the Asteraceae family and is used as medicine with root or whole plant. Alias: Tusanqi, Blood Setqi, Water Sanqi, Gootou Sanqi, Little Angelica, Poxuedan, Jinbuhuan, Purple Sanqi, Xueqi, Tie Sui Han, etc. It has the effects of hemostatic, ringworm, pain relief, and amidships. . The roots contain protein, polysaccharides, tannins, organic acids, pigments, alkaloids and other ingredients. The bi-fused ring pyrrolidine-type alkaloid-chrysanthemum notoginsengine, whose molecular formula is C 18 H 25 NO 5 When hydrolyzed with 4% KOH methanol solution, hypoalkali and hypoacid are obtained. The hydrochloride of hypoalkaline is Retrnecine.HCl ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P7/04A61P29/00A61P19/02A61P19/08A61K125/00
Inventor 赵宋亮陶春元谢宝华许茹
Owner JIUJIANG UNIVERSITY
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