Composition of Chinese medicine extract for treating diabetes

A technology of composition and extract, which is applied in the field of medicine to achieve the effects of lowering blood sugar, effectively treating diabetes, and controlling quality

Inactive Publication Date: 2009-05-20
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the traditional Chinese medicine treatment of diabetes has the above-mentioned research basis, there is no specific Chinese medicine drug for the treatment

Method used

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  • Composition of Chinese medicine extract for treating diabetes
  • Composition of Chinese medicine extract for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Scutellaria baicalensis 267g is pulverized into coarse powder, adds 6 times the amount of 75% ethanol, reflux extracts for 1 hour, and filters; adds 5 times the amount of 75% ethanol to the dregs, reflux extracts, filters, and carries out twice; Concentrate under pressure to 1 / 6 of the original volume, apply D101 macroporous resin, elute with 6 times column volume of water, then use 90% ethanol to elute until the effluent is light in color; collect the alcohol eluate, and recover under reduced pressure solvent, washed the obtained solid with absolute ethanol to obtain a yellow powder, and dried at 60°C to obtain 40 g of total flavonoids of Scutellaria baicalensis.

[0022] Coptidis 2259g was crushed into coarse powder, added 6 times the amount of 0.5% sulfuric acid aqueous solution, extracted under reflux for 0.5 hours, filtered; added 5 times the amount of 0.5% sulfuric acid aqueous solution to the dregs, refluxed extracted, filtered, twice; merged three times Concentr...

Embodiment 2

[0027] Scutellaria baicalensis 267g is pulverized into coarse powder, adds 8 times the amount of 75% ethanol, reflux extracts for 1.5 hours, and filters; adds 5 times the amount of 75% ethanol to the dregs, reflux extracts, filters, and carries out twice; Concentrate under pressure to 1 / 6 of the original volume, apply D101 macroporous resin, elute with 6 times the column volume of water, then use 90% ethanol to elute until the effluent is light in color; collect the alcohol eluate, and recover the solvent under reduced pressure , washed the obtained solid with absolute ethanol to obtain a yellow powder, and dried at 60° C. to obtain 40 g of total flavonoids of Scutellaria baicalensis.

[0028] Coptidis 2260g was crushed into coarse powder, added 8 times the amount of 0.5% sulfuric acid aqueous solution, extracted under reflux for 1 hour, filtered; added 5 times the amount of 0.5% sulfuric acid aqueous solution to the dregs, refluxed extracted, filtered, twice; merged three time...

Embodiment 3

[0033] Scutellaria baicalensis 135g is pulverized into coarse powder, adds 10 times the amount of 75% ethanol, reflux extraction for 2 hours, and filters; adds 5 times the amount of 75% ethanol to the dregs, reflux extraction, and filters twice; Concentrate under pressure to 1 / 6 of the original volume, apply D101 macroporous resin, elute with 6 times the column volume of water, then use 90% ethanol to elute until the effluent is light in color; collect the alcohol eluate, and recover the solvent under reduced pressure , washed the obtained solid with absolute ethanol to obtain a yellow powder, and dried at 60° C. to obtain 20 g of total flavonoids of Scutellaria baicalensis.

[0034] Coptidis 2260g was crushed into coarse powder, added 10 times the amount of 0.5% sulfuric acid aqueous solution, extracted under reflux for 1.5 hours, filtered; added 5 times the amount of 0.5% sulfuric acid aqueous solution to the dregs, refluxed extracted, filtered, twice; merged three times Con...

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Abstract

The invention relates to a composition of traditional Chinese medicine extracts for treating diabetes, which is a composition of extracts of scutellaria, coptis and astragalus, in particular extracts of 20 to 40 percent of scutellaria total flavone, 30 to 50 percent of coptis total alkaloids and 20 to 40 percent of astragalus total polysaccharide by weight percentage, preferably ratio of the extracts being 40 percent to 40 percent to 20 percent, 25 percent to 50 percent to 25 percent, and 1 to 1 to 1. Baicalin is used as a standard, the content of the scutellaria total flavone measured by a UV method is 80 to 89 percent, and the content of the baicalin measured by an HPLC method is 15 to 23 percent. Berberine hydrochloride is used as a reference substance, the content of the coptis total alkaloids measured by the UV method is 70 to 90 percent, and the content sum of jateorhizine, palmatine and berberine measured by the HPLC method is 50 to 68 percent. Anhydrous dextrose is used as a standard, and the content of the astragalus total polysaccharide measured by a UV phenol-sulphuric acid method is 30 to 60 percent.

Description

technical field [0001] The invention relates to a composition of traditional Chinese medicine extracts for treating diabetes, specifically, a composition composed of effective parts of Scutellaria baicalensis, Coptis chinensis and Radix astragali, belonging to the technical field of medicine. Background technique [0002] Diabetes mellitus is a group of clinical metabolic diseases caused by the interaction of genetic and environmental factors. Due to the absolute or relative deficiency of insulin secretion and the decreased sensitivity of target tissue cells to insulin, sugar, protein, fat, water and electrolytes are caused. and other metabolic disorders. Clinically, high blood sugar is the main common sign. Prolonged illness can cause damage to multiple systems, and acute metabolic disorders such as ketoacidosis can occur when the condition is severe and stressful. Diabetes is divided into type I diabetes (insulin-dependent diabetes mellitus, IDDM) and type II diabetes mel...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P3/10
Inventor 周明眉赵爱华贾伟杨红舟牟鲁霞
Owner SHANGHAI UNIV OF T C M
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