Pawpaw total phenolic acid extract and use thereof

A technology of total phenolic acid and extract, which is applied in the application field of total phenolic acid extract of papaya to prepare anti-inflammatory drugs or food, can solve the problem of reducing whole plasma viscosity, erythrocyte aggregation and fibrinogen content, anti-model large Shorten the coagulation time of mice, achieve obvious anti-inflammatory activity, and the effect of simple preparation method

Inactive Publication Date: 2009-06-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

It is reported that total glucosides of papaya has a strong preventive effect on rat immune arthritis model, and pharmacological experiments show that after oral administration of total glycosides of papaya (30, 60, 120mg/kg) in rats with adjuvant arthritis, the Abnormally elevated whole plasma viscosity, erythrocyte aggregation, and fibrinogen c

Method used

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  • Pawpaw total phenolic acid extract and use thereof
  • Pawpaw total phenolic acid extract and use thereof
  • Pawpaw total phenolic acid extract and use thereof

Examples

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Embodiment 1

[0017] Example 1 Preparation of the extract of papaya total phenolic acids

[0018] Take 100kg dried papaya with wrinkled skin, crush it, pass it through a 10-mesh sieve, put it into an extraction tank, soak it in 200L of 70% ethanol at room temperature for 24 hours, collect the soaking liquid, and extract the medicinal material for 3 times with 1500L of 70% ethanol at room temperature , collect the percolation liquid, combine the soaking liquid and percolation liquid and concentrate to 50L, filter, and absorb the filtrate with polystyrene porous macroporous resin as usual, the macroporous resin in the column is 200L, rinse with 1500L distilled water Remove impurities, then elute with 2000L 10% aqueous ethanol, collect the eluate and concentrate until it has no alcohol smell, then use the same method for secondary macroporous resin adsorption and elution, and get brown powdered papaya after drying Total phenolic acid extract 0.25kg. Calculated according to the dosage of crude...

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Abstract

The invention relates to a pawpaw total phenolic acid exact and its application for preparing anti-inflammatory medicament and food belonging to the medicine technology field. The exact prepared from pawpaw fruit of the invention is called pawpaw total phenolic acid exact because composition analysis shows that: its main component contains catechuic acid 30-35%, chlorogenic acid 20-25, and phenolic acid compounds 50-60%. Animal experiments shows that: the pawpaw total phenolic acid exact achieves substantial anti-inflammatory activity, consequently, can be used for preparing anti-inflammatory medicament or food. The invention provides a new approach for new anti-inflammatory medicament.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the total phenolic acid extract of papaya and its application in the preparation of anti-inflammatory drugs or food. Background technique [0002] Papaya is a commonly used traditional Chinese medicine, which has the effects of calming the liver, relaxing tendons, harmonizing stomach and reducing dampness. The 2005 edition of "Chinese Pharmacopoeia" records that papaya is the dry and nearly ripe fruit of Chaenomeles speciosa (Sweet) Nakai, a Rosaceae plant, with wrinkled skin. Papaya is a product formed by processing its fruit. In addition, there are two other Rosaceae plants that are also widely used as papaya: papaya is the fruit of C. sinensis (Thouin) Koehen, a plant in the Rosaceae family; fruit. Papaya is mainly produced in Anhui, Shandong, Zhejiang, Hubei, Yunnan, Guizhou, Sichuan and other places, and mainly contains organic acids, triterpenoids, flavonoids, polysacchari...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61P29/00A23L1/30A61K131/00
Inventor 孙连娜陈万生李霞杨颖博邱彦
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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