Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer
A technology for peptic ulcer and baicalin zinc, which is applied to the application field of compound baicalin zinc in the preparation of anti-peptic ulcer medicines, and can solve the problems such as the treatment of peptic ulcer with baicalin zinc which has not been seen.
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[0009] One. The effect of the compound of the present invention on acute gastric ulcer in mice induced by water immersion stress
[0010] 70 healthy female ICR mice were randomly divided into 6 groups with 10 mice in each group, which were model control group, ligand control baicalin group, baicalin zinc high-dose group 0.2mg / kg, baicalin zinc middle-dose group 0.1mg / kg, low dose of baicalin zinc 0.05mg / kg, positive control omeprazole group, zinc gluconate control group. Each group was prepared with 0.5% sodium carboxymethyl cellulose, administered by intragastric administration at 20 ml / kg, once a day, for 6 days in total. One hour after the last administration, the mice were fixed on the mouse clip board, and placed in a constant temperature water bath at 20°C at the level of the xiphoid process for 20 hours of stress to cause stress gastric ulcers. After that, the animals were killed by neck dislocation, and the stomach Put it in 1% formaldehyde and fix it for 10 minutes, ...
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