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Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine

A kind of cosmetic composition, technology of ergothioneine, applied in the field of cosmetic composition

Inactive Publication Date: 2009-08-05
LVMH研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] Currently, few methods allow the direct measurement of enzyme activities involved in repairing altered DNA bases in cells, especially since a high degree of specificity is required due to the large number of alterations present

Method used

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  • Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine
  • Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine
  • Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Example 1: Measuring the biological activities of ergothioneine treatment and ascorbic acid 2-glucoside treatment on DNA damage repair ability of cultured normal human fibroblasts respectively.

[0087] Fibroblasts were obtained from breast samples of a 52-year-old Caucasian woman and photo-protected skin of a 39-year-old Asian woman (Japanese).

[0088] 1.1 Method

[0089] 1.1.1 Handling fibroblasts

[0090] Fibroblasts (Caucasian (FHN52) and Asian (FHN1C)) from each donor were cultured and processed in exponential growth phase.

[0091] Fibroblasts were treated with ergothioneine (AGI Dermatics, Newport, NY, USA) at a non-cytotoxic concentration of 4 mM for 24 hours.

[0092]Fibroblasts were treated with ascorbic acid 2-glucoside (Siber Hegner, Miribel, France) at a non-cytotoxic concentration of 50 [mu]M for 24 hours.

[0093] Cells were then washed and detached by trypsinization.

[0094] Untreated controls (NT) were run in parallel for each point.

[0095] Cel...

Embodiment 2

[0164] Example 2: face cream

[0165] The proportions of the following 4 compositions are given in percentages (by weight relative to the total weight). Cyclopentasiloxane 12.90

[0166] Butanediol 11.00

[0167] PEG-7 Dimethicone 5.00

[0168] Phenyltrimethylsiloxane 2.50

[0169] Glycerin 2.00

[0170] Vinyl Dimethicone / Methicone Silsesquioxane

[0171] (methicone silsesquioxane) cross-linked polymer 1.50

[0172] Neopentyl glycol diethylhexanoate (neopentyl glycol

[0173] diethylhexanoate) 1.00

[0174] Silica dimethyl silylate

[0175] silylate) 0.80

[0176] Sodium citrate 0.50

[0177] Sodium chloride 0.50

[0178] Trimethylsiloxysilicate 0.50

[0179] Preservatives 0.70

[0180] Tocopheryl acetate 0.20

[0181] Ergothioneine 0.01

[0182] Tetrasodium edetate 0.10

[0183] Spice 0.04

[0184] Sodium Hyaluronate 0.01

[0185] Potassium sorbate <0.01

[0186] Water make up to 100%

Embodiment 3

[0187] Example 3: Eye Night Serum

[0188] Glycerin 3.05

[0189] Butanediol 3.00

[0190] Squalane 2.90

[0191] Cetearyl Ethylhexanoate 2.60

[0192] Ascorbic acid 2-glucoside 2.00

[0193] Stearyl ether 21 (Steareth-21) 1.20

[0194] Myristyl myristate 1.00

[0195] Polymethylmethacrylate 1.00

[0196] Glyceryl Stearate 0.80

[0197] Preservatives 0.70

[0198] Mica 0.65

[0199] Sodium citrate 0.45

[0200] Cetyl alcohol 0.40

[0201] Stearyl Alcohol 0.40

[0202] Sodium hydroxide 0.30

[0203] Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.30

[0204] Polyacrylamide 0.24

[0205] Xanthan gum 0.20

[0206] Dimethicone 0.20

[0207] Tetrasodium edetate 0.20

[0208] C13-14 isoparaffin 0.15

[0209] Stearic acid 0.05

[0210] Palmitic acid 0.05

[0211] Spice 0.03

[0212] Laureth-7 (Laureth-7) 0.03

[0213] Citric acid 0.02

[0214] Potassium sorbate <0.01

[0215] Water make up to 100%

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Abstract

This invention relates to a cosmetic composition allowing the effects of skin aging to be reduced or delayed, comprising as the cosmetically active ingredients ascorbic acid 2-glucoside and ergothioneine. The invention also relates to the use of these cosmetically active ingredients in a cosmetic composition as agents to stimulate DNA repair enzymes, particularly enzymes to repair oxidised DNA bases in dermal and epidermal cells. Finally, the invention relates to a cosmetic treatment process involving this use.

Description

technical field [0001] The present invention relates to a cosmetic composition having the effect of reducing or delaying skin aging, comprising ascorbyl 2-glucoside and ergothioneine as cosmetic active ingredients. The present invention also relates to the use of these cosmetic active ingredients in cosmetic compositions as agents for stimulating DNA repair enzymes, in particular enzymes that repair oxidized DNA bases in skin and epidermal cells. Finally, the invention relates to a method of cosmetic treatment related to said use. Background technique [0002] Skin aging is determined by genetic and environmental factors. [0003] More specifically, there are two types of skin aging: [0004] - Intrinsic or chronological aging, which affects the skin in the same way as other organs, corresponding to the inevitable changes caused by the aging process; [0005] - Extrinsic aging related to environmental factors. The term "actinic aging" or "heliodermatosis" refers to the c...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/49A61K8/97A61Q19/00A61Q19/08
CPCA61K8/676A61K8/4946A61Q19/08A61Q17/04A61K2800/78A61K8/60A61Q19/00
Inventor 罗宾·库菲尔斯特玛蒂尔德·博内-迪凯努瓦
Owner LVMH研究所
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