Fast screening method for metronidazole in cosmetic

A technology for cosmetics and metronidazole, applied in the field of rapid screening of metronidazole in cosmetics, can solve the problems of unsuitable fluidity, expensive instruments, large-scale on-site detection, etc., achieve intuitive and reliable inspection results, improve operational efficiency, The effect of major social benefits

Active Publication Date: 2009-08-05
广东省药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the above-mentioned chromatographic and ELISA methods can accurately detect metronidazole in cosmetics, etc., both methods have complex operations, long sample processing time, and cannot perform rapid screening for large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Example 1 Qupan Cleansing Milk

[0027] The Qupan cleansing milk in this embodiment is an ointment cosmetics. First, prepare the experimental equipment:

[0028] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0029] Take about 1g of Qupan Cleansing Milk, place it in a small beaker, add 2ml of 0.3mol / L acetic acid solution, heat and stir in a water bath at 60℃ to dissolve, pour the liquid obtained after boiling into a test tube, add 30% by mass hydrogen Place 5 drops of sodium oxide solution in an electric heating cup and heat it in a water bath at 50℃ for 2 minutes. During this time, shake it a little and observe continuously. Observation of the color shows that the color of the solution turns to pink, which indicates that nails may be added to the Facial Cleanser. Nidazole.

Example Embodiment

[0030] Example 2 Acne-removing and benefiting skin lotion

[0031] The acne-removing and skin-benefiting lotion of this embodiment is a solution cosmetics. First, prepare the experimental equipment:

[0032] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0033] Take 2ml of anti-acne skin lotion, put it in a test tube, add 8 drops of 30% by mass sodium hydroxide solution, heat it in a water bath at 60°C for 2 minutes, shake it a bit and observe it continuously. Observation of the color reveals that the color of the solution turns to purple-red. This indicates that metronidazole may be added to the acne-removing skin water.

Example Embodiment

[0034] Example 3 Strong acne repair cream

[0035] The potent acne repair cream of this embodiment is an ointment type cosmetic. First, prepare experimental equipment:

[0036] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0037] Take about 1.5g of the powerful acne repair cream, put it in a small beaker, add 2ml of 1mol / L acetic acid solution, heat and stir in a water bath at 50℃ to dissolve, pour the liquid obtained after boiling into a test tube, and add 40% by mass 6 drops of sodium hydroxide solution, placed in an electric heating cup, heated in a 70°C water bath for 2 minutes, shaken a little during this time and observed continuously. Observation of the color reveals that the color of the solution does not change, indicating that no metronidite is added to the powerful acne repair cream Azole.

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Abstract

The invention discloses a method for rapidly selecting and detecting the cosmetic containing metronidazole, which comprises the steps of adding alkali liquor into the cosmetic to be detected, heating the alkali liquor and the cosmetic at a temperature of 50-80 DEG C in a water bath heating way so that the alkali liquor and the cosmetic conduct the color development reaction, judging whether the metronidazole is added in the cosmetic according to the color development reaction result. In the case of cream cosmetic, adding acid liquor into the cream cosmetic before adding the alkali liquor, heating the acid liquor and the cream cosmetic until the cream cosmetic is melted down, and adding the alkali liquor into the solution of the acid liquor and the cream cosmetic. The method does not need any large-sized instrument and is easy to operate; the cosmetic sample containing the metronidazole can be selected for the subsequent precision chromatogram detection according to the color development reaction judgment; the method is helpful for supervision departments to select large-batch cosmetic samples, simplifies the detection procedures, reduces the detection cost and can be used for high-flowability cosmetic sample detection.

Description

technical field [0001] The invention relates to a detection method for metronidazole, in particular to a rapid screening method for metronidazole in cosmetics. Background technique [0002] Metronidazole (English name is Metronidazole, MNZ), its chemical name is: 2-methyl-5-nitroimidazole-1-ethanol, and its molecular formula is C 6 h 9 N 3 o 3 , the trade names are metronidazole, metronidazole, metronidazole, metronidazole. Metronidazole (MNZ) is a nitroimidazole drug. It is a broad-spectrum anti-intestinal insecticide that can kill amoebas. It is also effective against anaerobic bacilli and cocci. It is also used for surgical infections. It is approved by the World Health Organization ( WHO) selected as the basic drug for the treatment of anaerobic infection. In addition, metronidazole has a good killing effect on scabies mites, can treat scabies, and kill the rod-shaped bacteria that cause inflammatory acne, so it is effective for acne and is widely used. Used in cosm...

Claims

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Application Information

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IPC IPC(8): G01N21/78
Inventor 关日晴梁祈刘敏敏李晨辉
Owner 广东省药品检验所
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