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Fast screening method for metronidazole in cosmetic

A technology for cosmetics and metronidazole, applied in the field of rapid screening of metronidazole in cosmetics, can solve the problems of unsuitable fluidity, expensive instruments, large-scale on-site detection, etc., achieve intuitive and reliable inspection results, improve operational efficiency, The effect of major social benefits

Active Publication Date: 2009-08-05
广东省药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the above-mentioned chromatographic and ELISA methods can accurately detect metronidazole in cosmetics, etc., both methods have complex operations, long sample processing time, and cannot perform rapid screening for large quantities of samples to be detected. In addition, chromatography has problems such as expensive instruments, easy contamination of chromatographic columns, high analysis cost and unsuitability for on-site detection with large fluidity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Cleansing milk for removing scabies

[0027] The anti-weed cleanser of the present embodiment is an ointment cosmetic, first prepare the experimental equipment:

[0028] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0029] Take about 1g of scabies cleansing milk, put it in a small beaker, add 2ml of 0.3mol / L acetic acid solution, heat and stir in a water bath at 60°C to dissolve, pour the liquid obtained after boiling into a test tube, and add 30 mass% hydrogen Put 5 drops of sodium oxide solution in an electric heating cup, heat it in a water bath at 50°C for 2 minutes, shake it slightly and observe it continuously. The color observation shows that the color of the solution turns pink, indicating that there may be formazan Nitazole.

Embodiment 2

[0030] Example 2 Acne Removing Tonic Lotion

[0031] The acne-removing and skin-reinforcing lotion of this embodiment is a solution cosmetic, first prepare the experimental apparatus:

[0032] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0033] Take 2ml of Acne Relief Lotion, put it in a test tube, add 8 drops of 30% by mass sodium hydroxide solution, heat in a water bath at 60°C for 2 minutes, shake slightly and observe continuously, the color observation shows that the color of the solution turns purple, It means that metronidazole may be added to the Acne Relief Tonic Water.

Embodiment 3

[0034] Example 3 Powerful Acne Repair Cream

[0035] The powerful acne repair cream of this embodiment is an ointment cosmetic, first prepare the experimental equipment:

[0036] Beakers, glass rods, droppers, test tubes, reagent bottles and electric heating cups.

[0037] Take about 1.5g of powerful acne repair cream, put it in a small beaker, add 2ml of 1mol / L acetic acid solution, heat and stir in a water bath at 50°C to dissolve, pour the liquid obtained after boiling into a test tube, and add 40% by mass Put 6 drops of sodium hydroxide solution in an electric heating cup, heat it in a water bath at 70°C for 2 minutes, shake it slightly and observe it continuously. The color observation shows that the color of the solution does not change, which means that there is no metronidrone added in this powerful acne repair cream. azole.

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Abstract

The invention discloses a method for rapidly selecting and detecting the cosmetic containing metronidazole, which comprises the steps of adding alkali liquor into the cosmetic to be detected, heating the alkali liquor and the cosmetic at a temperature of 50-80 DEG C in a water bath heating way so that the alkali liquor and the cosmetic conduct the color development reaction, judging whether the metronidazole is added in the cosmetic according to the color development reaction result. In the case of cream cosmetic, adding acid liquor into the cream cosmetic before adding the alkali liquor, heating the acid liquor and the cream cosmetic until the cream cosmetic is melted down, and adding the alkali liquor into the solution of the acid liquor and the cream cosmetic. The method does not need any large-sized instrument and is easy to operate; the cosmetic sample containing the metronidazole can be selected for the subsequent precision chromatogram detection according to the color development reaction judgment; the method is helpful for supervision departments to select large-batch cosmetic samples, simplifies the detection procedures, reduces the detection cost and can be used for high-flowability cosmetic sample detection.

Description

technical field [0001] The invention relates to a detection method for metronidazole, in particular to a rapid screening method for metronidazole in cosmetics. Background technique [0002] Metronidazole (English name is Metronidazole, MNZ), its chemical name is: 2-methyl-5-nitroimidazole-1-ethanol, and its molecular formula is C 6 h 9 N 3 o 3 , the trade names are metronidazole, metronidazole, metronidazole, metronidazole. Metronidazole (MNZ) is a nitroimidazole drug. It is a broad-spectrum anti-intestinal insecticide that can kill amoebas. It is also effective against anaerobic bacilli and cocci. It is also used for surgical infections. It is approved by the World Health Organization ( WHO) selected as the basic drug for the treatment of anaerobic infection. In addition, metronidazole has a good killing effect on scabies mites, can treat scabies, and kill the rod-shaped bacteria that cause inflammatory acne, so it is effective for acne and is widely used. Used in cosm...

Claims

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Application Information

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IPC IPC(8): G01N21/78
Inventor 关日晴梁祈刘敏敏李晨辉
Owner 广东省药品检验所
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