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N-acetylcysteine compound medicinal preparation for treating atherosclerosis

A technology for acetylcysteine ​​and atherosclerosis, applied in the field of N-acetylcysteine ​​compound pharmaceutical preparations, can solve problems such as the mechanism of action of combination therapy that has not been seen

Inactive Publication Date: 2009-08-12
孟晓萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] After searching, there is no research on the mechanism of the combination therapy of the two in atherosclerosis

Method used

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  • N-acetylcysteine compound medicinal preparation for treating atherosclerosis
  • N-acetylcysteine compound medicinal preparation for treating atherosclerosis
  • N-acetylcysteine compound medicinal preparation for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Take 15mg of NAC and 100mg of salvianolic acid and pulverize them into 100-200 mesh fine powder, and make NAC and Danshen compound tablet medicine according to the conventional tablet preparation process. This project complies with the relevant requirements of the Pharmacopoeia of the People's Republic of China 2000 Edition tablet project.

Embodiment 2

[0106] Take 10mg of NAC and 50mg of salvianolic acid and grind them into 100-200 mesh fine powder, and make NAC and Danshen compound capsules according to the conventional capsule preparation process. This project complies with the relevant requirements of the capsule project of the Pharmacopoeia of the People's Republic of China 2000 Edition.

Embodiment 3

[0108] Take 30g of NAC and 200mg of salvianolic acid and pulverize them into 100-200 mesh fine powder, and make NAC and salvia miltiorrhiza composite powder according to the conventional powder preparation process. This project complies with the relevant requirements of the powder project of the Pharmacopoeia of the People's Republic of China 2000 Edition.

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PUM

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Abstract

The invention provides an N-acetylcysteine (NAC) compound medicinal preparation for curing atherosclerosis, which is mainly prepared from NAC and salvianolic acid according to parts by weight. The compound pharmaceutical preparation for curing atherosclerosis with NAC and salvia miltiorrhiza being the main active components has obvious medicinal curative effect by intervening in anti-oxidation and inhibiting MMP-2 (matrix metallopeptidase 2) from generating.

Description

technical field [0001] The invention provides an N-acetylcysteine ​​compound pharmaceutical preparation for treating atherosclerosis, which belongs to the technical field of combined traditional Chinese and western medicine. Background technique [0002] The N-acetylcysteine ​​(hereinafter referred to as: NAC) that the present invention relates to has a structural formula as follows: [0003] [0004] Molecular formula: C 5 h 9 NO 3 S, the molecular weight is 163.19. [0005] As a drug, N-acetylcysteine ​​is currently mainly used in the treatment of respiratory infections, such as acute and chronic bronchitis, chronic obstructive pulmonary disease, emphysema, bronchiectasis and viscous mucus disease, etc., in the treatment of atherosclerosis Sclerosis has not been reported. [0006] Salvia miltiorrhiza is mainly used to treat irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat arthralgia ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/198A61P9/10
Inventor 孟晓萍崔建华费瑜王智慧韩冰崔燕王莉
Owner 孟晓萍