Capparis spinosa extract and capparis spinosa emulsifiable paste and method for producing the same

Abstract

The invention relates to a caper extract, a caper cream and a production method thereof. The caper extract contains 1.2-2.0 percent total alkaloids according to the weight percentage. Raw materials of the caper cream comprise caper, stearic acid, glycerin monostearate, white Vaseline, glycerin, sodium dodecyl sulfate, laurocapram and ethyl p-hydroxybenzaote. The pharmacodynamic test results show that the caper cream can significantly promote the formation of epidermal granular layer in the scales of mouse-tail., significantly inhibit the mitosis of mouse vaginal epithelial cells, reduce the dextran-induced mouse itching times and the itching sustained total time, inhibit the xylene-induced mouse auricula edema and the acetic acid-induced mouse peritoneal capillary permeability increase and promote the generation of mouse hemolysin antibody. The preparation is prompted to have better therapeutic effect for mouse scleroderma and psoriasis. The caper cream has good transdermal absorption, durable action, no irritation and easy smearing, washing and removal by patients.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a caper extract, a caper cream and a production method thereof. Background technique [0002] Scleroderma is a connective tissue disease characterized by progressive skin and visceral fibrosis. Modern medicine divides it into two categories: localized and systemic. Systemic sclerosis (SS) is a connective tissue disease characterized by progressive sclerosis of collagen fibers in the skin and various systems. ET (endothelin, ET) is released by fibroblasts, and is It plays an important role in , a naturally occurring protein that has multiple effects on the vascular system. Nodular scleroderma is a fibrotic reaction characterized by well-defined, firm, raised nodules resembling scars. Scleroderma is characterized by progressive swelling, hardening, and atrophy of the skin and internal organs, which seriously affects the quality of life of patients. The pathogenesis of the disease...

AI Technical Summary

Problems solved by technology

At present, there are no reports about the extract, preparation and production method. The present invention has been searched for patents at home and abroad for nearly 15 years, and there is no relevant caper extract, caper cream and production method thereof in the treatment of scleroderma and Reports on psoriasis