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Pharmaceutically acceptable salt and polymorphic forms of Flupirtine maleate

A technology of flupirtine maleate and polymorphs, applied in the field of polymorphs of flupirtine maleate

Inactive Publication Date: 2009-08-12
普利瓦·赫尔瓦茨卡有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although flupirtine does not appear to bind to any of the identified binding sites associated with the NMDA receptor complex, it has several functional NMDA antagonistic properties

Method used

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  • Pharmaceutically acceptable salt and polymorphic forms of Flupirtine maleate
  • Pharmaceutically acceptable salt and polymorphic forms of Flupirtine maleate
  • Pharmaceutically acceptable salt and polymorphic forms of Flupirtine maleate

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Embodiment Construction

[0046] As used herein, the term "therapeutically effective amount" refers to the amount of the polymorphic form of flupirtine maleate of the present invention that is capable of preventing, ameliorating or eliminating the disease state that is centrally responsible for its administration. Disease state with opioid analgesics, muscle relaxants, functional NMDA antagonists, or substances that increase expression of the protein Bcl-2.

[0047] "Pharmaceutically acceptable" means that the carrier, diluent or excipient is compatible with the polymorphic form of flupirtine maleate of the present invention and is harmless to the recipient thereof.

[0048] In the pharmaceutical composition of the present invention for oral, sublingual, subcutaneous, intramuscular, intravenous, topical, intratracheal, intranasal, transdermal or rectal administration, the polymorphic flupirtine maleate of the present invention The unit dosage forms mixed with conventional pharmaceutical carriers are ad...

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Abstract

The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical compositions containing them, therapeutic uses thereof and methods of treatment employing them.

Description

technical field [0001] The present invention relates to novel polymorphic forms of flupirtine maleate, processes for the preparation of said novel polymorphic forms, pharmaceutical compositions comprising them, therapeutic uses thereof and methods of treatment employing them. Background technique [0002] The chemical name of flupirtine maleate is 2-amino 6-[(4-fluorobenzyl) amino] pyridine-3-carbamate ethyl ester maleate, which can be represented by the following structural formula: [0003] [0004] Flupirtine is a centrally acting non-opioid analgesic without the typical side effects of natural or synthetic opioids such as respiratory depression, constipation, tolerance, physiological and / or psychological dependence and susceptibility to addiction. It is also a muscle relaxant. Although flupirtine does not appear to bind to any of the identified binding sites associated with the NMDA receptor complex, it has several functional NMDA antagonistic properties. Flupirtine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/75A61K31/44A61P25/04
CPCC07D213/75A61P21/02A61P25/00A61P25/04A61P25/16A61P25/28A61P29/00
Inventor A·达尼洛夫斯基M·德维希克M·马林科维克E·麦斯特罗维克T·姆多佛I·唐吉克
Owner 普利瓦·赫尔瓦茨卡有限责任公司
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