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Method of screening for compounds with anti-amyloid properties

A technology for screening compounds and amyloid proteins, applied in the medical field, can solve the problems of not meeting the conditions of structural validity, not being representative, not meeting the conditions of descriptive validity, etc.

Inactive Publication Date: 2009-08-12
LES LAB SERVIER
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  • Abstract
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  • Application Information

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Problems solved by technology

This in vitro method is faster than the method described above, but does have the disadvantage of not being representative of the complex present in humans, since rat brain extracts are used and the Aβ peptide is introduced exogenously
Thus, for screening that can act on Aβ 42 - method for compounds of the α7 nAChR complex (the complex is located at the origin of amyloid plaque formation), this model meets neither the conditions of construct validity nor descriptive validity required for use in this method

Method used

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  • Method of screening for compounds with anti-amyloid properties
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  • Method of screening for compounds with anti-amyloid properties

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Embodiment Construction

[0056] I. Materials and methods

[0057] I.1) Patients

[0058] Postmortem human frontal cortices from Alzheimer's disease patients and healthy control subjects were obtained from brain banks (Harvard Brain Tissue Resource Center and Analytical Biological Services).

[0059] Patients and control subjects included in this study were between the ages of 50 and 90 years.

[0060] Control subjects were people who showed no signs of cognitive impairment or memory loss while alive.

[0061] Moreover, Alzheimer's disease patients were divided into two subgroups with and without associated vascular disease. Only brains from patients without associated diseases were used in this study.

[0062] It should be noted that in patients showing clinical symptoms, the diagnosis of Alzheimer's disease was confirmed by immunohistochemical methods described by the National Institute on Aging and the Reagan Institute Diagnostic Criteria Working Group. Working Groupon Diagnostic Criteria) app...

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Abstract

The invention relates to a method of screening for compounds with anti-amyloid properties. The method of screening for compounds which have the ability to dissociate or prevent high-affinity complexes between ss-amyloid peptides and nicotinic acetylcholine receptors of human cortex tissues makes it possible to rapidly identify compounds for use in the curative and / or preventive treatment of neurodegenerative diseases and of Alzheimer's disease in particular.

Description

field of invention [0001] The present invention relates to the field of medicine, especially the part of pharmacology research. The present invention actually relates to methods of screening compounds for anti-amyloid properties. [0002] To this end, the present invention uses biochemical techniques for the ex vivo analysis of biological samples, allowing the rapid identification of compounds intended for the treatment and / or prevention of neurodegenerative diseases, in particular Alzheimer's disease. The present invention therefore relates to a method of screening for compounds capable of dissociating high affinity complexes between amyloid beta peptides and nicotinic acetylcholine receptors in human cortical tissue. Background technique [0003] Alzheimer's disease is a progressive neurodegenerative disease that affects a large proportion of the elderly population. Clinically, the disease is characterized by memory loss and cognitive decline. Neuropathologically, Alzhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47G01N33/50G01N33/68
CPCG01N2500/02C07K14/4711G01N2333/4709G01N2333/70571G01N2800/2821G01N33/6896A61P21/04A61P25/14A61P25/16A61P25/28A61P43/00
Inventor H-Y·王P·莫兰C·蒂比耶日
Owner LES LAB SERVIER
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