Miao medicine 103 deer-blood element medicine for resisting multi-drug resistant pulmonary tuberculosis and preparation method of 103 deer-blood element

A technology for multi-drug resistance and tuberculosis, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of small side effects, small doses of drugs, low toxicity, etc., and achieve low recurrence rate, Less dosage, better effect

A technology for multi-drug resistance and tuberculosis, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of small side effects, small doses of drugs, low toxicity, etc., and achieve low recurrence rate, Less dosage, better effect

CN101507799AInactive Publication Date: 2009-08-19贵州百灵企业集团乾元制药有限公司
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Effect test

preparation example Construction

[0012] The preparation method and steps of the Miao medicine 103 deer blood element anti-multidrug resistance pulmonary tuberculosis medicine of the present invention:

[0013] First put the fresh deer blood or dried deer blood (crushed) into a 500 liter enzymolysis tank; wash the giant centipede (Miao medicine: Gangku) with deionized water, grind it into a slurry, add dilute salt water to mix, and stir After 3-5 hours, filter, repeat three times, combine the filtrate, adsorb on a resin column, adjust the pH of the eluate to 4-8, precipitate the protease, and filter, which is the centipede 103 protease; dissolve the centipede 103 protease in the water-soluble colloidal liquid and prepare To 5-30% of 103 protease solution, add 103 protease solution to deer plasma, stir for 3-30 hours, dry at 30-70°C, pulverize, and pass through an 80-mesh sieve to obtain powdered 103 deer blood element.

[0014] Using this 103 deer blood element as a raw material and Baiji (Miao medicine name: Bigo...

Embodiment 1

[0021] Prepare 103 protease solution:

[0022] First wash the giant centipede with deionized water, grind it into a slurry, add dilute salt water, stir at 0-25℃ for 3-5 hours, extract the protease, repeat three times, combine the filtrate, filter and remove the residue, and put the filtrate on the resin column for washing After removing, the eluent is adjusted to pH 4-8, precipitation, and the precipitate is filtered to obtain centipede 103 protease. The centipede protease is dissolved in a water-soluble glue solution to prepare a 0.1-10% 103 protease solution.

Embodiment 2

[0024] Use fresh deer blood to prepare 103 deer blood element:

[0025] Mix 5-30% of the 0.1-10% protease solution in Example 1 and 70-95% of fresh deer blood. Stir for 3-30 hours, dry at 30-70°C, pulverize, and pass through an 80-mesh sieve to obtain the finished product 103 deer blood element in powder form.

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Abstract

The invention discloses a miao medicine 103 deer sanguinin multi-drug resistance tuberculosis drug. Fresh deer blood or dry deer blood is added with powdery 103 deer sanguinin biodegraded by 103 protease of scolopendra subspinipes multilans or 103 protease of other animals, plants, bacteria and fungi; and the mixture is added with rhizoma bletillae, water, notoginseng and auxiliary materials to form the tuberculosis drug. The invention also discloses a method for preparing 103 deer sanguinin. The drug can rapidly improve human immune function and physical quality and achieve functions of autologous antibiosis and sterilization, thereby rapidly curing tuberculosis and multi-drug resistance tuberculosis; and the drug has little dosage, short treatment course and extremely low recurrence rate. A product is matched with a few western antitubercular drugs for combined treatment, can remarkably reduce toxicity and side effect of western drugs, has better effect on multi-drug resistance tuberculosis and achieves huge social effect and economic benefit for improving the status of Chinese medicine for resisting tuberculosis disease.

Description

Technical field [0001] The invention relates to an anti-tuberculosis and multi-drug resistant pulmonary tuberculosis drug, in particular to a preparation method of the 103 deer blood element anti-multidrug resistant pulmonary tuberculosis drug of Miao medicine and 103 deer blood element. Background technique [0002] Tuberculosis is a chronic infectious disease that seriously threatens the lives of all human beings. Tuberculosis causes great damage and harm to the social environment and economy. There are currently more than 40 million pulmonary tuberculosis patients in the world, of which more than 30 million are multi-drug resistant patients. These multi-drug resistant patients are ineffective or relapsed in combination with multiple western medicines, and they have not cured for a long time and become a new infection of pulmonary tuberculosis. source. The world is still increasing at a rate of 10% every year, and anti-multidrug-resistant tuberculosis has become a major issue i...

Claims

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Application Information

Patent Timeline
19 Aug 2009
Publication
CN101507799A
IPC
A61K36/898; A61K35/14; A61P31/06; A61P11/00
Inventors
陈光裕