Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

BCL inhibitors treating platelet excess

A compound, methyl technology, applied in the field of BCL inhibitors for the treatment of excessive platelets, can solve problems such as deterioration

Inactive Publication Date: 2013-11-06
ABBVIE INC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although circulating platelet production is a common physiological process, some diseases can be caused or exacerbated by excessive or undesired activation of platelets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • BCL inhibitors treating platelet excess
  • BCL inhibitors treating platelet excess
  • BCL inhibitors treating platelet excess

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0919] 3-((Chloro(difluoro)methyl)sulfonyl)-N-(4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-ene- 1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl )amino)benzenesulfonamide

Embodiment 2

[0921] N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl )benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoro Methyl)sulfonyl)benzenesulfonamide

Embodiment 3

[0923] N-(4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzyl Acyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl) Benzenesulfonamide

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti-apoptotic Bcl-2 family protein members is disclosed.

Description

technical field [0001] The present invention encompasses methods of reducing platelet numbers in mammals and preventing or treating prothrombotic conditions and diseases characterized by excessive or undesired activation of platelets using anti-apoptotic Inhibitors of members of the Bcl-2 family of proteins. Background technique [0002] Platelets are enucleated blood cells derived from megakaryocytes that are essential for proper hemostasis and thrombus formation. Apoptosis-like processes are also associated with platelet biogenesis (ie, platelet production) and aging (ie, old age). The process of apoptosis has been extensively studied in nucleated cells; however, its role in enucleated cells has been less addressed. Cytochrome c, caspase-9, caspase-3, and APAF-1 have been reported to be expressed in platelets, suggesting that platelets contain the essential apoptotic machinery to execute programmed cell death. Several studies have shown that Bcl-2 family proteins (i.e....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5377A61K31/495A61K31/496A61P7/02A61P9/00A61P35/02
CPCA61K31/495A61K31/00A61K31/496A61K31/5377A61P35/02A61P43/00A61P7/00A61P7/02A61P9/00A61P9/10
Inventor S·W·埃尔莫尔S·罗森伯格G·戈顿
Owner ABBVIE INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com