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BCL inhibitors treating platelet excess

A compound, methyl technology, applied in the field of BCL inhibitors for the treatment of excessive platelets, can solve problems such as deterioration

Inactive Publication Date: 2013-11-06
ABBVIE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although circulating platelet production is a common physiological process, some diseases can be caused or exacerbated by excessive or undesired activation of platelets

Method used

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  • BCL inhibitors treating platelet excess
  • BCL inhibitors treating platelet excess
  • BCL inhibitors treating platelet excess

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0919] 3-((Chloro(difluoro)methyl)sulfonyl)-N-(4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-ene- 1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl )amino)benzenesulfonamide

Embodiment 2

[0921] N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl )benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoro Methyl)sulfonyl)benzenesulfonamide

Embodiment 3

[0923] N-(4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzyl Acyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl) Benzenesulfonamide

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Abstract

Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti-apoptotic Bcl-2 family protein members is disclosed.

Description

technical field [0001] The present invention encompasses methods of reducing platelet numbers in mammals and preventing or treating prothrombotic conditions and diseases characterized by excessive or undesired activation of platelets using anti-apoptotic Inhibitors of members of the Bcl-2 family of proteins. Background technique [0002] Platelets are enucleated blood cells derived from megakaryocytes that are essential for proper hemostasis and thrombus formation. Apoptosis-like processes are also associated with platelet biogenesis (ie, platelet production) and aging (ie, old age). The process of apoptosis has been extensively studied in nucleated cells; however, its role in enucleated cells has been less addressed. Cytochrome c, caspase-9, caspase-3, and APAF-1 have been reported to be expressed in platelets, suggesting that platelets contain the essential apoptotic machinery to execute programmed cell death. Several studies have shown that Bcl-2 family proteins (i.e....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5377A61K31/495A61K31/496A61P7/02A61P9/00A61P35/02
CPCA61K31/495A61K31/00A61K31/496A61K31/5377A61P35/02A61P43/00A61P7/00A61P7/02A61P9/00A61P9/10
Inventor S·W·埃尔莫尔S·罗森伯格G·戈顿
Owner ABBVIE INC