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Moldavica dragonhead general flavone extract as well as preparation method and application thereof

A technology for total flavonoids and extracts, which is applied to the total flavonoids extract of Radix japonica and the fields of preparation and application thereof, can solve the problems of unclear medicinal effect substances, large dosage of medicines, poor quality controllability and the like

Inactive Publication Date: 2009-09-23
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although in recent years, there have been many literatures on the scavenging of free radicals, the treatment of coronary heart disease, and the reduction of blood lipids, etc., the research objects are all decoctions or extracts of xiangqinglan, and Yixin Badiran Jibuya Granules are also crude preparations made by decocting and concentrating in water. The effective substances are not clear, the dosage is large, and the quality controllability is not strong.

Method used

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  • Moldavica dragonhead general flavone extract as well as preparation method and application thereof
  • Moldavica dragonhead general flavone extract as well as preparation method and application thereof
  • Moldavica dragonhead general flavone extract as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of total flavonoids extract of Xiangqinglan

[0028] 50Kg of fenugreek, reflux extraction with 50% ethanol 10 times the weight of the medicinal material, 3 times for 1 hour each time, combine the extracts, filter, and concentrate to extract. The extract is diluted 10 times with water, and adsorbed on a macroporous resin column (HPD100, Hebei Baoen Chemical Industry Co., Ltd.). The ratio of the weight of the original medicinal material to the volume of the macroporous resin is 1:5 (g:ml), and the diameter-to-height ratio of the chromatographic column is 1:10. , was eluted with distilled water, the eluent was discarded, and then eluted with 75% ethanol at a flow rate of 1 column volume / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain that, with a yield of 2.5%.

Embodiment 2

[0029] Embodiment 2: the preparation of total flavonoids extract of sweet green orchid

[0030] 50Kg of fenugreek, reflux extraction with 50% ethanol which is 8 times the weight of the medicinal material, 3 times for 1 hour each time, combine the extracts, filter, and concentrate to extract. Dilute the extract by 10 times with water, put it on a polyamide column for adsorption (60-90 mesh), the ratio of the weight of the original medicinal material to the volume of the polyamide is 1:3 (g:ml), the diameter-height ratio of the chromatographic column is 1:8, wash with distilled water After elution, the eluent was discarded, and then eluted with 75% ethanol at a flow rate of 1 column volume / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain the obtained product with a yield of 2.8%.

Embodiment 3

[0031] Embodiment 3: the preparation of total flavonoids extract of sweet green orchid

[0032] 50Kg of Cymbidium japonica, reflux extraction with 95% ethanol equal to the weight of the medicinal material for 8 times, each time for 5 hours, combined extracts, filtered, concentrated to extract. The extract is diluted 20 times with water, and adsorbed on a macroporous resin column (HPD100, Hebei Baoen Chemical Industry Co., Ltd.). The ratio of the weight of the original medicinal material to the volume of the macroporous resin is 1:10 (g:ml), and the diameter-to-height ratio of the chromatographic column is 1:20. , was eluted with distilled water, the eluent was discarded, and then eluted with 95% ethanol at a flow rate of 2 column volumes / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain that, with a yield of 1.9%.

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Abstract

The invention discloses a moldavica dragonhead general flavone extract which is prepared by the following method: firstly, using ethanol to extract; then using a macroporous resin column or a daiamid column to adsorb; using the ethanol to elute; and collecting the ethanol eluting liquid to carry out vacuum concentration or vacuum drying or spray drying or freeze drying so as to obtain the moldavica dragonhead general flavone extract. The content of general flavone in the moldavica dragonhead general flavone extract is more than 50 percent, and dracocephalum moldavica of a flavonoid compound which is a main effective constituent is more than 5.0 percent. The obtained moldavica dragonhead general flavone extract can be used for preparing medicaments or health care products for treating arteriosclerosis, coronary heart diseases and coronarism.

Description

technical field [0001] The invention relates to an extract of total flavonoids of fennel orchid and its preparation method and application. Background technique [0002] Coronary heart disease is one of the diseases that seriously endanger human health. The disease has a high morbidity rate, high mortality rate, and complicated pathogenesis, which makes the prevention and treatment of this disease a difficult point. This kind of therapeutic drugs has always been a hot research topic for pharmaceutical workers. Herbal medicine has unique advantages in the prevention and treatment of coronary heart disease, and has achieved good clinical results. [0003] Dracocephalum moldavica L. is an annual herb of the genus Dracocephalum moldavica of the family Lamiaceae, and is a traditional medicinal material of the Uygur and Mongolian nationalities. The standards of medicinal materials are recorded in the Uyghur medicine sub-volume of "Drug Standards of the Ministry of Health" (standa...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/10
Inventor 娄红祥任冬梅王亚俊
Owner SHANDONG UNIV
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