Medicinal composition containing dimeticone/simethicone

A technology of simethicone and simethicone, which is applied in the field of medicine, achieves the effect of simple preparation process, exact effect and guaranteed safety

Inactive Publication Date: 2009-12-09
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is often used clinically for dyspnea caused by a large amount of sticky sputum, such as dyspnea after surgery, acute and chronic bronchitis, bronchiec...

Method used

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  • Medicinal composition containing dimeticone/simethicone
  • Medicinal composition containing dimeticone/simethicone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Preparation of ethylamino silicone oil composition granules

[0069] 1. Prescription:

[0070] Simethicone 100g

[0071] Silica 5g

[0072] Acetylcysteine ​​500g

[0073] Sucrose powder 200g

[0074] Proper amount of ethanol

[0075]

[0076] A total of 1000 bags were made

[0077] 2. Specific steps:

[0078] (1) Pass acetylcysteine ​​and sucrose powder through a 100-mesh sieve respectively, and set aside;

[0079] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0080] (3) After mixing simethicone and silicon dioxide, place it at 150°C for 3 hours, take it out after cooling;

[0081] (4) After mixing acetylcysteine ​​with sucrose powder and starch evenly, add it to the mixture of simethicone and silicon dioxide, mix it several times to make it uniform, and use an appropriate amount of ethanol to make a suitable soft material;

[0082] (5) prepare wet granules with 20 mesh sieves;

...

Embodiment 2

[0091] Preparation of ethylamine silicone oil composition powder

[0092] 1. Prescription:

[0093] Simethicone 50g

[0094] Acetylcysteine ​​400g

[0095] Glucose 850g

[0096] Micronized silica gel 50g

[0097]

[0098]

[0099] A total of 1000 bags were made

[0100] 2. Specific steps:

[0101] (1) Acetylcysteine ​​and glucose are passed through a 100-mesh sieve respectively, and set aside;

[0102] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0103] (3) Adsorb simethicone with glucose, mix thoroughly to make it uniform, then mix evenly with acetylcysteine ​​and micropowder silica gel to obtain a semi-finished product;

[0104] (4) The semi-finished product is filled into bags after being inspected for appearance and content of the main drug to obtain the finished product;

[0105] (5) After the finished product passes the inspection, it is put into storage.

[0...

Embodiment 3

[0109] Preparation of ethylamino silicone oil composition suspension

[0110] 1. Prescription:

[0111] Simethicone 50g

[0112] Silica 2.5g

[0113] Acetylcysteine ​​100g

[0114] Microcrystalline Cellulose 30g

[0115] Xanthan gum 5g

[0116] Aspartame 5g

[0117] Ethylparaben 2g

[0118] Disodium edetate 1g

[0119] Ethanol 20g

[0120] 1M sodium hydroxide solution appropriate amount

[0121]

[0122] Purified water up to 1000ml

[0123] 2. Specific steps:

[0124] (1) Acetylcysteine, microcrystalline cellulose, and xanthan gum are passed through a 100-mesh sieve respectively, and set aside; purified water is boiled and deoxidized, set aside; sodium hydroxide is prepared into a sodium hydroxide solution with a concentration of 1M, set aside ;

[0125] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0126] (3) After mixing simethicone and silicon dioxide, place it at 150°C for 3 hours, take...

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PUM

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Abstract

The invention discloses a medicinal composition containing dimeticone/simethicone. The composition is mainly prepared from the following raw material medicaments in portion by weight: 1 to 1,000 portions of acetylcysteine or pharmaceutically acceptable salt thereof, and 1 to 500 portions of the dimeticone/simethicone. The composition can be prepared into various pharmaceutically acceptable preparations; and the composition can be applied to gastrointestinal endoscopy and treatment or an adjuvant drug administered before imaging examination, and compared with the acetylcysteine or the dimeticone or simethicone which is in single use at the same dosage, the composition has stronger defrothing effect, and stronger grume removal effect, so that the composition can effectively improve the visual definition of examination and treatment, reduce misdiagnosis and missed diagnosis, and improve effectiveness of diagnosis and treatment, contributes to early diagnosis discovery of digestive tract diseases, and has wide application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition of acetylcysteine ​​or its pharmaceutically acceptable salt and simethicone / simethicone. Background technique [0002] Digestive endoscopy plays a very important role in the diagnosis of gastrointestinal diseases. It is favored by doctors because of its intuitiveness and simplicity, and it is especially commonly used in clinical diagnosis and treatment. However, due to the large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is prolonged, the patient’s pain is increased, and it is easy to cause misdiagnosis and missed diagnosis, which is not conducive to the early diagnosis and discovery of digestive tract diseases. [0003] Simethicone (I) is the most commonly used medical antifoaming agent clinically, and is often used for preoperative defoaming in digestive endoscopy and treatment or abdominal im...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K47/34A61K47/24A61K49/00
CPCA61K49/00A61K31/198A61K9/16
Inventor 王国华赵小萍刘萍罗成文
Owner 重庆健能医药开发有限公司
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