Anti-sunstroke application of baicalin

A technology of baicalin and ability, which is applied in the field of anti-heat stroke, can solve the problems of inconvenient use and no obvious prospect of the human body, and achieve the effects of prolonging the survival time, delaying the occurrence of heat stroke and animal death, and delaying death

Inactive Publication Date: 2010-05-26
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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Problems solved by technology

Intraperitoneal injection of baicalin is effective. Although it shows that baicalin has important phar

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  • Anti-sunstroke application of baicalin
  • Anti-sunstroke application of baicalin

Examples

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Embodiment 1

[0018] Example 1 Study on the protective effect of baicalin on heatstroke rats

[0019] 1. Materials and Methods

[0020] Baicalin Tablets, produced by Hunan Kuntaichun Pharmaceutical Co., Ltd. (No. 75 Chenjiawan, Yanggutang, Yuhu District, Xiangtan City), approval number: Guoyao Zhunzi H43021781, specification 0.25g / tablet, aluminum-plastic blister packaging, product Batch number: 20070201, valid until January 2009. The molecular weight is 446.38, and it is a light yellow tablet. Take 2 baicalin tablets, grind them thoroughly, add water for injection to fully dissolve them, and then dilute to 50ml. The effective concentration of baicalin is 10mg / ml, and store them at room temperature. The experimental rats were Wistar rats, male, weighing 180-220 g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. The rats were fasted overnight the day before the experiment.

[0021] Use a super constant temperature water bath, connect the plexiglass ...

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Abstract

The invention relates to an anti-sunstroke application of baicalin (beta-D-gluconic acid-5,6-dihydroxy-4-oxo-2-phenyl-4H-benzopyran-7). Under the condition of oral administration, the baicalin can obviously delay the sunstroke of rats in the thermal environment, extend the survival time of the rats suffering from sunstroke and put off the death of the rats in the thermal environment. The inventor feeds adult rats baicalin of certain concentration by intragastric administration, then observes the sunstroke and the survival time of the rats, and discovers that feeding the rats the baicalin of certain concentration by intragastric administration can obviously delay the sunstroke of the rats in the thermal environment, put off the death of the rats in the thermal environment, simultaneously extend the survival time of the rats suffering from sunstroke, and improve the anti-sunstroke capability of the rats. When feeding a proper amount of common medicant baicalin at the proper time by the method, the anti-thermal injury capability of the rats can be improved, thereby providing strong evidences to human experiments. When the baicalin is applied to human bodies, better economic benefits and social benefits can be obtained.

Description

technical field [0001] The invention relates to an anti-heat stroke application of baicalin. Under the condition of oral administration, baicalin can significantly delay the occurrence of heatstroke in rats in hot environment, prolong the survival time of heatstroke rats, and delay the death of rats in hot environment. Background technique [0002] Preventive measures for thermal environment damage and heatstroke are important topics in environmental medicine, military medicine, and aerospace medicine. So far, there is still no satisfactory drug for preventing heatstroke. [0003] Baicalin is one of the main components extracted from the dry root of Scutellaria baicalensis Georgi, a plant in the Labiatae family, and it is the component with the strongest pharmacological effect among the active ingredients of Scutellaria baicalensis. Baicalin (C 21 h 18 o 11 ), has pharmacological effects such as clearing heat and detoxifying, antibacterial and anti-inflammatory, chelatin...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P43/00
Inventor 赵永岐范明刘淑红吴燕赵彤
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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