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Anti-heatstroke use of teprenone

A teprenone and human-enhancing technology, applied in the field of anti-heat stroke, achieving good economic and social benefits, delaying the occurrence of heat stroke, and improving the ability to resist heat damage

Active Publication Date: 2011-04-20
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cerebral ischemia is also one of the main pathophysiological mechanisms of heat stroke. Whether teprenone can resist heat injury or heat stroke by inducing the expression of HSP70 has not been reported yet.

Method used

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  • Anti-heatstroke use of teprenone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Study on the protective effect of teprenone on heat stroke rats

[0018] 1. Materials and Methods

[0019] Teprenone, produced by Japan Eisai Company, product batch number: 041281, sub-packaging batch number 041281B, molecular weight 330.55. It is white powder. Weigh 50 mg of deteprenone, add 2% gum arabic to a final volume of 5 ml, fully dissolve and store at room temperature. The rats used in the experiment were Wistar rats, weighing 180-220 g, male, and the rats were fasted overnight the day before the experiment.

[0020] Use a super constant temperature water bath, connect the plexiglass interlayer water circulation chamber, control the room temperature at 23-24°C, and keep the measured temperature of the heat circulation chamber at 40.5-41°C. Put the rats in the heat chamber, monitor the changes in the anal temperature and blood pressure of the rats, and take the moment when the mean arterial pressure drops 25mmHg from the peak value as the beginning ...

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Abstract

The present invention relates to an application of teprenone (geranylgeranylacetone, GGA) for resisting heatstroke. Under the condition of peroral administration, the teprenone can obviously delay rat heatstroke in a heat environment and prolong surviving time of the rate with heatstroke. Different concentration of teprenone is given to adult rats by gavage, subsequently the rat heatstroke and the surviving time of the rate are observed. The result shows that a certain concentration of teprenone given by gavage in advance can obviously delay the rat heatstroke in the heat environment, and prolong the surviving time of the rat with heatstroke, and improve the anti-heatstroke ability. Through the method of the invention, the common medicine teprenone with a proper dosage is taken at a proper time, which can improve the rat anti-heatstroke ability, and provide powerful evidence for human experiment. If the method can be popularized to human application, better economic benefit and social benefit can be achieved.

Description

technical field [0001] The invention relates to an anti-heat stroke application of teprenone (digeranylacetone). Under the condition of oral administration, teprenone can significantly delay the occurrence of heatstroke in rats in a hot environment and prolong the survival time of heatstroke rats. Background technique [0002] Preventive measures for thermal environment damage and heatstroke are important topics in environmental medicine, military medicine, and aerospace medicine. So far, there is still no satisfactory drug for preventing heatstroke. [0003] Teprenone (geranylgeranylacetone, GGA) is a relatively safe HSP70 inducer, which is commonly used in the treatment of ulcer disease. Teprenone can reduce the cytotoxic effect (Bai, 2002) and neuron injury (Kikuchi, 2002) that chemical substance causes by inducing HSP70; Vestibular cell injury (Takumida, 2005), epilepsy (Fujiki, 2003; 2004), cerebral infarction (Nagai, 2005; Yasuda, 2005; Nikaido, 2004) and so on have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/121A61P43/00
Inventor 赵永岐范明鄢友娥汪晖王鲁明刘淑红
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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