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Pyridazine derivatives and their use as therapeutic agents

A kind of medicine and compound technology, applied in the field of inhibitors of stearoyl-CoA desaturase

Inactive Publication Date: 2010-05-26
XENON PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the known SCD inhibitor compounds are selective for SCD or delta-9 desaturases because they also inhibit other desaturases and enzymes

Method used

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  • Pyridazine derivatives and their use as therapeutic agents
  • Pyridazine derivatives and their use as therapeutic agents
  • Pyridazine derivatives and their use as therapeutic agents

Examples

Experimental program
Comparison scheme
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preparation example 1

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Embodiment 11

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Abstract

The invention relates to pyridazine derivatives and their use as therapeutic agents. Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R<2>, R<3>, R<4>, R<5>, R<6>, R<6a>, R<7>, R<7a>, R<8>, R<8a>, R<9> and R<9a> are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Description

This application is a divisional application of the patent application with the application number 200480021842.X, the application date is 29th, 2004, and the invention title is "pyridazine derivatives and their use as therapeutic agents". technical field The present invention relates generally to the field of inhibitors of stearoyl-CoA desaturases, such as pyridazine derivatives, and the use of such compounds in the treatment and / or prevention of various human diseases, including Those diseases mediated by acyl-CoA desaturase (SCD) enzymes, preferably SCD1 , especially those associated with elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, etc. Background technique Acyl desaturases catalyze the formation of double bonds in fatty acids derived from dietary sources or de novo synthesis in the liver. Mammals synthesize at least three fatty acid desaturases with different chain length specificities that catalyze the addition of double bonds...

Claims

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Application Information

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IPC IPC(8): C07D237/20C07D237/22A61K31/501A61P3/10A61P3/08A61P5/50A61P3/04A61P1/16A61P3/06A61P17/10A61P3/00A61K31/00A61K31/551C07D213/75C07D213/76C07D213/81
CPCA61K31/00A61K31/551C07D213/81C07D237/22C07D213/75A61K31/501C07D237/20C07D213/76A61P1/16A61P17/10A61P3/00A61P3/04A61P3/06A61P3/08A61P43/00A61P5/50A61P7/12A61P9/00A61P3/10
Inventor H·W·戈施文德V·柯杜穆鲁刘世峰R·卡姆博耶
Owner XENON PHARMACEUTICALS INC