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Sinomenine and honokiol composition and anti-angiogenic drug taking sinomenine and honokiol composition as active ingredient having synergistic action

A technology of active ingredients and compositions, applied in the field of anti-angiogenesis drugs, can solve the problems of complex experimental links, huge combination space, high cost, etc.

Inactive Publication Date: 2010-06-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current field of drug research and development, the method of measuring the strength of synergy between drugs is mainly done through in vivo and in vitro experimental research. Due to the huge combination space, the experimental process is complicated and the cost is high.

Method used

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  • Sinomenine and honokiol composition and anti-angiogenic drug taking sinomenine and honokiol composition as active ingredient having synergistic action
  • Sinomenine and honokiol composition and anti-angiogenic drug taking sinomenine and honokiol composition as active ingredient having synergistic action
  • Sinomenine and honokiol composition and anti-angiogenic drug taking sinomenine and honokiol composition as active ingredient having synergistic action

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Experimental program
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Effect test

Embodiment 1

[0064] The inventors used the NIMS method to screen anti-angiogenesis drug combinations. There are 63 candidate drugs, and 63 candidate drugs form 63*(63-1) / 2=1953 drug combinations. The implementation effect is as follows:

[0065] The 63 drug candidates included two drug combinations known to have anti-angiogenic interactions: 5-fluorouracil+vinblastine, and 5-fluorouracil+rapamycin. Predicted by NIMS method, among all 1953 combinations, these two drug combinations known to have synergistic effects are all in the top three (see Table 1), and the results of the three gene networks are basically consistent. This example demonstrates the effectiveness of the NIMS method, which is capable of well finding drug combinations known to have synergistic effects.

[0066] Table 1. NIMS predictive ranking of known synergistic drug combinations among 1953 drug combinations

[0067]

[0068]

[0069] Cell proliferation assay validation of NIMS method results

[0070] Taking sinom...

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Abstract

The present invention relates to an anti-angiogenic drug, a composition and an application of the composition as the active ingredient of the anti-angiogenic drug. The composition consists of sinomenine and honokiol. The drug is selected with a method for determining the synergistic action of medical composition based on biologic network (non-invasive microsphere NIMS method). Cell proliferation experimental detection proves that the composition really has active drug synergistic action.

Description

technical field [0001] The present invention relates to an anti-angiogenesis drug, a composition, and the application of the composition as an active ingredient of an anti-angiogenesis drug. The composition consists of sinomenine and honokiol. Background technique [0002] The development of drug combinations with synergistic effects is a new way to treat many diseases at present; the so-called synergistic effect (Synergistic effect) means that the effect of two drugs in combination is greater than the sum of the effects of the two drugs alone at the same dose. In the applicant's Chinese patent application No. 200610114226.X (authorized), a combination of pharmaceutical ingredients with synergistic effects is described, which is hereby cited in its entirety. However, in the current field of drug research and development, the method of measuring the synergy between drugs is mainly done through in vivo and in vitro experimental research. Due to the huge combination space, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/05A61P35/00A61P7/00
Inventor 李梢张宁波张博
Owner TSINGHUA UNIV
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