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Xiaoaiping pill and preparing method thereof

A technology for Pingdi Pills and gastric cancer, applied in the field of Xiaoai Pingdi Pills and their preparation, can solve the problems of first-pass effect bioavailability of liver and intestines, large dust pollution and environmental pollution, affecting treatment effect, etc., so as to improve bioavailability , No dust pollution, the effect of increasing safety

Inactive Publication Date: 2010-06-23
双鹤药业(海南)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for most oral preparations, due to the preparation technology and other reasons, there are problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the performance of the drug. It also directly affects the therapeutic effect
Moreover, due to the granulation process in the preparation process, relatively large dust pollution and environmental pollution will be generated, and the production cost is relatively high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 1500g of black bone vine, soak it for 12 hours, add water to decoct three times, add 10 times the amount of water for the first extraction for 2 hours, add 8 times the amount of water for the second extraction for 1.5 hours, and add 6 times the amount of water for the third extraction for 1 hour , combined decoction, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.23 to 1.25 (70°C to 80°C), dried under reduced pressure to form a dry extract, and crushed through a 100-mesh sieve. Use PEG4000 as the matrix, melt it at a ratio of 1:1.5 (dry extract: PEG4000), mix it with the extract evenly, put it on a dropping pill machine, drop it into 1000 pills, remove the oil and dry it. Every 1000 servings of Xiaoaiping dripping pills contains 1500g of extract of Aegypti sinensis medicinal material.

Embodiment 2

[0014] Take 1500g of black bone vine, soak it for 12 hours, add water to decoct three times, add 10 times the amount of water for the first extraction for 2 hours, add 8 times the amount of water for the second extraction for 1.5 hours, and add 6 times the amount of water for the third extraction for 1 hour , combined decoction, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.23 to 1.25 (70°C to 80°C), dried under reduced pressure to form a dry extract, and crushed through a 100-mesh sieve. Use PEG1000 as the matrix, melt it at a ratio of 1:2 (dry extract: PEG4000), mix it evenly with the extract, put it on a dropping pill machine, drop it into 1000 pills, remove the oil and dry it. Every 1000 servings of Xiaoaiping dripping pills contains 1500g of extract of Aegypti sinensis medicinal material.

Embodiment 3

[0016] Take 1500g of black bone vine, soak it for 12 hours, add water to decoct three times, add 10 times the amount of water for the first extraction for 2 hours, add 8 times the amount of water for 1.5 hours for the second extraction, and add 6 times the amount of water for 1 hour for the third extraction , combined decoction, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.23 to 1.25 (70°C to 80°C), dried under reduced pressure to form a dry extract, and crushed through a 100-mesh sieve. Use poloxamer as the matrix, melt it at a ratio of 1:2.5 (dry extract: PEG4000), mix it evenly with the extract, put it on a dropping pill machine, drop it into 1000 pills, remove the oil and dry it. Every 1000 servings of Xiaoaiping dripping pills contains 1500g of extract of Aegypti sinensis medicinal material.

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PUM

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Abstract

The invention relates to a medicine composition which is used for treating esophageal cancer, gastric cancer, lung cancer, colorectal cancer, cervical cancer, leukemia and other malignancies, can be matched with radiotherapy, chemotherapy and post-operative treatment, and is used for treating diseases such as chronic bronchitis, bronchial asthma and the like, in particular to an oral solid preparation prepared from glaucescent fissistigma root as Chinese herbal medicine raw material. The invention aims to remedy the defects of the existing oral preparations used for treating the diseases, and provides a medicine composition oral preparation with high bioavailability, rapid effect taking, low toxic and side effect and high drug content-Xiaoaiping pill. The Xiaoaiping pill is prepared by taking glaucescent fissistigma root as the raw material together with a medical carrier used as a matrix. The matrix is one of or the mixture of two of polyethylene glycol 1000, polyethylene glycol 4000 and poloxamer.

Description

technical field [0001] The present invention relates to a medicine for esophageal cancer, gastric cancer, lung cancer, colorectal cancer, cervical cancer, leukemia and other malignant tumors, which can also be combined with radiotherapy, chemotherapy and post-operative treatment, and can be used for the treatment of chronic bronchitis and bronchial asthma. The pharmaceutical composition, in particular relates to an oral solid preparation prepared from the Chinese herbal medicine raw material. technical background [0002] Black bone vine (namely Tongguan vine): it is the dry cane of Marsdenia tenacissima (Roxb.) Wight et Arn. [0003] According to the national drug standard (standard number: WS 3 -B-3959-98) prepared by the formula and extraction process given by Xiaoai plain tablets, a clinically used for esophageal cancer, gastric cancer, lung cancer, colorectal cancer, cervical cancer, leukemia and other malignant tumors, can also be used It is combined with radiotherap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61K9/20A61K47/34A61P35/00A61P11/00A61P11/06A61K125/00A61K47/10
Inventor 魏雪纹申洁李强
Owner 双鹤药业(海南)有限责任公司
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