N,N-dimethyl piper-ridinium chloride sustained-release microcapsules and preparation method thereof

A technology of methylpiperium and microcapsules, which is applied in the field of agriculture and can solve the problems of fast release of active ingredients, ecological damage, and short duration of action

Active Publication Date: 2013-04-17
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the methylpiperium registered in my country mainly has two dosage forms: soluble powder and water. These two dosage forms have obvious disadvantages such as fast release of active ingredients, short duration, poor stability, and a large amount of release into the environment. Increased agricultural labor costs, low crop bioavailability, and potential environmental hazards and ecological damage

Method used

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  • N,N-dimethyl piper-ridinium chloride sustained-release microcapsules and preparation method thereof
  • N,N-dimethyl piper-ridinium chloride sustained-release microcapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1, average particle diameter 60 μ m methylpiperium sustained-release microcapsules

[0025] The original drug selects 97.0% methylpiperium original powder produced by Jiangnan Pesticide Factory in Changzhou City, Jiangsu Province (the same as in the following examples).

[0026] Take by weighing 0.4g chitosan and 0.5g methylpiperium and dissolve in 20mL mass concentration and be 2% acetic acid solution, obtain mixed solution; Slowly add 1.0mL castor oil polyoxyethylene ether under the conditions, stir and emulsify for 30min, until the mixture is evenly dispersed; set the inlet temperature of the spray dryer to 150°C, and the outlet temperature to 95°C, and use the spray dryer to solidify and dry the resulting mixture. The obtained powder is mepiperium sustained-release microcapsules.

[0027] The prepared methylpiperium sustained-release microcapsules were observed with an electron microscope (Shimadzu S-3400 type) and their morphology was...

Embodiment 2

[0032] Embodiment 2, the preparation of mepiperium sustained-release microcapsules with an average particle diameter of 20 μm

[0033] Weigh 1.0g sodium alginate, 0.5g gelatin and 1.0g methylpiperium respectively and dissolve them in 100mL water to obtain a mixed solution; Slowly add 1.5mL tristyrylphenol polyoxyethylene polyoxypropylene ether, stir and emulsify for 40min until the mixture is uniformly dispersed; set the inlet temperature of the spray dryer to 145°C, and the outlet temperature to 85°C, and use the spray dryer to dissolve the resulting mixture Carry out curing and drying, and the obtained powder is mepiperium sustained-release microcapsules.

[0034] The method for measuring the performance index of the mepiperium sustained-release microcapsules prepared in this embodiment is the same as that in Example 1. The specific measurement results are: the cyst formation rate of methylpiperium is 83%, the drug loading rate is 21.3%, the average particle size is 19.1 μm...

Embodiment 3

[0036] Embodiment 3, preparation of mepiperium sustained-release microcapsules with an average particle diameter of 3 μm

[0037]Weigh 0.4g chitosan, 0.1g gelatin and 0.5g methylpiperium respectively and dissolve them in 20mL mass concentration of 2% acetic acid solution to obtain a mixed solution; Stir, and slowly add 0.8mL sorbitan monooleate polyoxyethylene ether under stirring conditions, stir and emulsify for 40min, until the mixture is evenly dispersed; set the inlet temperature to 125°C, the outlet temperature to 80°C, The obtained mixed liquid is solidified and dried, and the obtained powder is mepiperium sustained-release microcapsules.

[0038] The method for measuring the performance index of the mepiperium sustained-release microcapsules prepared in this embodiment is the same as that in Example 1. The specific measurement results are: the cyst formation rate of methylpiperium is 75%, the drug loading rate is 25.8%, the average particle size is 2.8 μm, and the rel...

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Abstract

The invention discloses N,N-dimethyl piper-ridinium chloride sustained-release microcapsules and a preparation method thereof. The microcapsules is prepared from the following materials: N,N-dimethyl piper-ridinium chloride, a degradable polymer and a hydrophilic emulsifier, wherein the mass ratio of the N,N-dimethyl piper-ridinium chloride to the degradable polymer is (0.1-10):1; the mass ratio of the degradable polymer to the hydrophilic emulsifier is 1: (0.125-4); and the capsule cores of the N,N-dimethyl piper-ridinium chloride microcapsules are made of N,N-dimethyl piper-ridinium chloride. In the invention, the N,N-dimethyl piper-ridinium chloride sustained-release microcapsules are prepared by selecting an easily degradable polymer capsule material, combining the easily degradable polymer capsule material in different ratios, emulsifying mixed liquid of the capsule material and the capsule cores with the hydrophilic emulsifier and subjecting the product of the emulsification to spray drying at certain inlet and outlet temperatures. The N,N-dimethyl piper-ridinium chloride sustained-release microcapsules of the invention are safe to human bodies, avoid environment pollution and have the advantages of controlling or sustaining the release of the N,N-dimethyl piper-ridinium chloride, improving bioavailability, prolonging an acting period, reducing medicament dosage, reducing the degradation of active ingredients in environment, improving the stability of the active ingredients and the like.

Description

technical field [0001] The invention belongs to the technical field of agriculture, and relates to a slow-release microcapsule of a plant growth regulator and a preparation method thereof, in particular to a methylpiperium slow-release microcapsule and a preparation method thereof. Background technique [0002] Methylpiperium, whose trade names are Bijiean, Pix, Zhuzhuangsu, etc., is a systemic plant growth regulator, which can promote the synthesis of chlorophyll in cotton plants, control the elongation of main stems and fruit branches, prevent crazy growth, and make The plant type is compact, the cotton beads are short and strong, and the early bolls can be increased, so it can increase the yield and improve the fiber quality. At the same time, it also has high physiological activity on crops such as soybeans, peanuts, wheat, peppers, and tomatoes. It is more widely used in agricultural production. A broad class of regulators. [0003] At present, the methylpiperium regis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/28A01N43/40A01P21/00
Inventor 段留生谭伟明朱晓峰周繁李召虎田晓莉张明才何钟佩
Owner CHINA AGRI UNIV
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