Compositions comprising acetic acid and hypochlorous acid and methods for treating biofilm

A composition and technology of hypochlorous acid, applied in the direction of hypochlorous acid, botanical equipment and methods, drug combination, etc., can solve the problems of not being widely available, difficult to use, and unable to effectively attack biofilms for a long time

Active Publication Date: 2019-11-01
WIAB WATER INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antiseptic compositions do not penetrate wounds deep enough to completely eradicate biofilm beneath the surface
Other sanitizing compositions disperse too quickly to effectively attack bi...

Method used

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  • Compositions comprising acetic acid and hypochlorous acid and methods for treating biofilm
  • Compositions comprising acetic acid and hypochlorous acid and methods for treating biofilm
  • Compositions comprising acetic acid and hypochlorous acid and methods for treating biofilm

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Embodiment 1: product analysis

[0175] When spectrophotometry is extended to also cover the visible range, color can be detected. The gas usually produced during the generation of HOCl is ClO 2 , Cl 2 O and Cl 2 , all of these gases are detectable in the visible range and appear yellow or yellow-red. Tzanavaras et al., (Central European J. of Chemistry, 2007, 5(1) 1-12). The data in Figure 9 demonstrate that HOCl produced by the method of the present invention exhibits no absorption of colored gases, as indicated by the absence of colored species. It is well known that HOCl produces a peak at 292 nm (Feng et al., 2007, J. Environ. Eng. Sci. 6, 277-284).

Embodiment 2

[0177] HOCl produced by the above method was stored under thermal stress at 40 °C in order to accelerate degradation using four different types of aqueous solutions: (1) reagent grade water (deionized water); (2) tap water; (3) with phosphate buffer reagent grade water; and (4) tap water with phosphate buffer. The properties of the HOCl product were monitored after initial reaction (T=0); 4 weeks (T=4); 8 weeks (T=8); and 12 weeks (T=12).

[0178] Figure 10 is a graph showing the amount (parts per million (ppm)) of HOCl initially produced (T=0) and its stability over time. The data showed that reagent grade water (deionized water) without phosphate buffer was most stable over 12 weeks, showing minimal product degradation compared to initial yield. The product produced using deionized water was much more stable than that produced using tap water. Furthermore, surprisingly, the data showed that phosphate buffer could negatively affect the yield of HOCl product.

[0179] Figur...

Embodiment 3

[0181] Embodiment 3: the comparison of acetic acid and hydrochloric acid

[0182] Using the method described above, hydrochloric acid (HCl) and acetic acid were used to prepare HOCl, which was then stored under thermal stress at 40°C. The amount of HOCl produced initially (T=0) was recorded, followed by the amount of HOCl product remaining after 12 days. Each case produces three batches. The data for HCl to HOCl are shown in Table 1. The data for HOCl produced from acetic acid are shown in Table 2.

[0183] Table 1: HOCl generation with HCl

[0184]

[0185] Table 2: HOCl generation with acetic acid

[0186]

[0187] The data show that use of acetic acid provides greater product stability, most likely due to greater stability of pH. Without being bound by any particular theory or mechanism of action, it is believed that acetic acid has a different protonation ability than hydrochloric acid, ie, acetic acid contributes fewer protons to the liquid than hydrochlo...

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PUM

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Abstract

Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions areuseful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Patent Application Serial No. 15 / 612,571, filed June 2, 2017; U.S. Provisional Patent Application Serial No. 62 / 438,189, filed December 22, 2016; U.S. Provisional Patent Application, filed December 22, 2016 Priority and Benefit of U.S. Provisional Patent Application Serial No. 62 / 438,202, filed December 22, 2016; and U.S. Provisional Patent Application Serial No. 62 / 438,204, filed December 22, 2016. [0003] The contents of each of the above-cited applications are hereby incorporated by reference in their entirety. technical field [0004] In general terms, the present invention relates to compositions of acetic acid and hypochlorous acid for use in the treatment of biofilms, particularly biofilms on tissues and in wounds, and other biofilm infections. Background technique [0005] Microbial infections that produce biofilms can cause serious health problems. Scientists estimate that up to...

Claims

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Application Information

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IPC IPC(8): A01N59/00A61K8/36A61K8/20A61K31/19C01B11/04
CPCA01N25/04A01N25/28A01N59/00A61K8/36A61K8/20C01B11/04A61Q11/00A61Q17/005A61K33/20A61K33/30A61K33/34A61K33/38A61P1/02A61P17/02A61P31/04A01N37/02A61K2300/00A61K31/19A61K9/51A61K9/0014
Inventor G·H·阿勒马斯
Owner WIAB WATER INNOVATION
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